Functional neurologic disorders in an adult with propionic acidemia: a case report

Abstract Background Inborn errors of metabolism are often characterized by various psychiatric syndromes. Previous studies tend to classify psychiatric manifestations into clinical entities. Among inborn errors of metabolism, propionic acidemia (PA) is a rare inherited organic aciduria that leads to...

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Autores principales:	Alexis Tarrada, Solène Frismand-Kryloff, Coraline Hingray
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Propionic acidemia Psychiatry Metabolic disorder Psychiatric profile Case report RC435-571
Acceso en línea:	https://doaj.org/article/92cc689593e148f48183bd0f396c589a
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spelling	oai:doaj.org-article:92cc689593e148f48183bd0f396c589a2021-11-28T12:06:58ZFunctional neurologic disorders in an adult with propionic acidemia: a case report10.1186/s12888-021-03596-21471-244Xhttps://doaj.org/article/92cc689593e148f48183bd0f396c589a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12888-021-03596-2https://doaj.org/toc/1471-244XAbstract Background Inborn errors of metabolism are often characterized by various psychiatric syndromes. Previous studies tend to classify psychiatric manifestations into clinical entities. Among inborn errors of metabolism, propionic acidemia (PA) is a rare inherited organic aciduria that leads to neurologic disabilities. Several studies in children with PA demonstrated that psychiatric disorders are associated to neurological symptoms. To our knowledge, no psychopathological description in adult with propionic acidemia is available. Case presentation We aimed to compare the case of a 53-year-old woman with PA, to the previous psychiatric descriptions in children with PA and in adults with other inborn errors of metabolism. Our patient presented a large variety of signs: functional neurologic disorders, borderline personality traits (emotional dyregulation, dissociative and alexithymic trends, obsessive-compulsive disorders), occurring in a context of neurodevelopmental disorder. Conclusion Clinical and paraclinical examinations are in favor of a mild mental retardation since childhood and disorders of behavior and personality without any definite psychiatric syndrome, as already described in other metabolic diseases (group 3). Nonetheless, further studies are needed to clarify the psychiatric alterations within adult patients with PA.Alexis TarradaSolène Frismand-KryloffCoraline HingrayBMCarticlePropionic acidemiaPsychiatryMetabolic disorderPsychiatric profileCase reportPsychiatryRC435-571ENBMC Psychiatry, Vol 21, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Propionic acidemia Psychiatry Metabolic disorder Psychiatric profile Case report Psychiatry RC435-571
spellingShingle	Propionic acidemia Psychiatry Metabolic disorder Psychiatric profile Case report Psychiatry RC435-571 Alexis Tarrada Solène Frismand-Kryloff Coraline Hingray Functional neurologic disorders in an adult with propionic acidemia: a case report
description	Abstract Background Inborn errors of metabolism are often characterized by various psychiatric syndromes. Previous studies tend to classify psychiatric manifestations into clinical entities. Among inborn errors of metabolism, propionic acidemia (PA) is a rare inherited organic aciduria that leads to neurologic disabilities. Several studies in children with PA demonstrated that psychiatric disorders are associated to neurological symptoms. To our knowledge, no psychopathological description in adult with propionic acidemia is available. Case presentation We aimed to compare the case of a 53-year-old woman with PA, to the previous psychiatric descriptions in children with PA and in adults with other inborn errors of metabolism. Our patient presented a large variety of signs: functional neurologic disorders, borderline personality traits (emotional dyregulation, dissociative and alexithymic trends, obsessive-compulsive disorders), occurring in a context of neurodevelopmental disorder. Conclusion Clinical and paraclinical examinations are in favor of a mild mental retardation since childhood and disorders of behavior and personality without any definite psychiatric syndrome, as already described in other metabolic diseases (group 3). Nonetheless, further studies are needed to clarify the psychiatric alterations within adult patients with PA.
format	article
author	Alexis Tarrada Solène Frismand-Kryloff Coraline Hingray
author_facet	Alexis Tarrada Solène Frismand-Kryloff Coraline Hingray
author_sort	Alexis Tarrada
title	Functional neurologic disorders in an adult with propionic acidemia: a case report
title_short	Functional neurologic disorders in an adult with propionic acidemia: a case report
title_full	Functional neurologic disorders in an adult with propionic acidemia: a case report
title_fullStr	Functional neurologic disorders in an adult with propionic acidemia: a case report
title_full_unstemmed	Functional neurologic disorders in an adult with propionic acidemia: a case report
title_sort	functional neurologic disorders in an adult with propionic acidemia: a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/92cc689593e148f48183bd0f396c589a
work_keys_str_mv	AT alexistarrada functionalneurologicdisordersinanadultwithpropionicacidemiaacasereport AT solenefrismandkryloff functionalneurologicdisordersinanadultwithpropionicacidemiaacasereport AT coralinehingray functionalneurologicdisordersinanadultwithpropionicacidemiaacasereport
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Functional neurologic disorders in an adult with propionic acidemia: a case report

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