The origins of novel protein interactions during animal opsin evolution.

<h4>Background</h4>Biologists are gaining an increased understanding of the genetic bases of phenotypic change during evolution. Nevertheless, the origins of phenotypes mediated by novel protein-protein interactions remain largely undocumented.<h4>Methodology/principle findings<...

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Autores principales:	David C Plachetzki, Bernard M Degnan, Todd H Oakley
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92cd2a4c11674c67acde5e05d5f38c24
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id	oai:doaj.org-article:92cd2a4c11674c67acde5e05d5f38c24
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spelling	oai:doaj.org-article:92cd2a4c11674c67acde5e05d5f38c242021-11-25T06:10:40ZThe origins of novel protein interactions during animal opsin evolution.1932-620310.1371/journal.pone.0001054https://doaj.org/article/92cd2a4c11674c67acde5e05d5f38c242007-10-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0001054https://doaj.org/toc/1932-6203<h4>Background</h4>Biologists are gaining an increased understanding of the genetic bases of phenotypic change during evolution. Nevertheless, the origins of phenotypes mediated by novel protein-protein interactions remain largely undocumented.<h4>Methodology/principle findings</h4>Here we analyze the evolution of opsin visual pigment proteins from the genomes of early branching animals, including a new class of opsins from Cnidaria. We combine these data with existing knowledge of the molecular basis of opsin function in a rigorous phylogenetic framework. We identify adaptive amino acid substitutions in duplicated opsin genes that correlate with a diversification of physiological pathways mediated by different protein-protein interactions.<h4>Conclusions/significance</h4>This study documents how gene duplication events early in the history of animals followed by adaptive structural mutations increased organismal complexity by adding novel protein-protein interactions that underlie different physiological pathways. These pathways are central to vision and other photo-reactive phenotypes in most extant animals. Similar evolutionary processes may have been at work in generating other metazoan sensory systems and other physiological processes mediated by signal transduction.David C PlachetzkiBernard M DegnanTodd H OakleyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 2, Iss 10, p e1054 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David C Plachetzki Bernard M Degnan Todd H Oakley The origins of novel protein interactions during animal opsin evolution.
description	<h4>Background</h4>Biologists are gaining an increased understanding of the genetic bases of phenotypic change during evolution. Nevertheless, the origins of phenotypes mediated by novel protein-protein interactions remain largely undocumented.<h4>Methodology/principle findings</h4>Here we analyze the evolution of opsin visual pigment proteins from the genomes of early branching animals, including a new class of opsins from Cnidaria. We combine these data with existing knowledge of the molecular basis of opsin function in a rigorous phylogenetic framework. We identify adaptive amino acid substitutions in duplicated opsin genes that correlate with a diversification of physiological pathways mediated by different protein-protein interactions.<h4>Conclusions/significance</h4>This study documents how gene duplication events early in the history of animals followed by adaptive structural mutations increased organismal complexity by adding novel protein-protein interactions that underlie different physiological pathways. These pathways are central to vision and other photo-reactive phenotypes in most extant animals. Similar evolutionary processes may have been at work in generating other metazoan sensory systems and other physiological processes mediated by signal transduction.
format	article
author	David C Plachetzki Bernard M Degnan Todd H Oakley
author_facet	David C Plachetzki Bernard M Degnan Todd H Oakley
author_sort	David C Plachetzki
title	The origins of novel protein interactions during animal opsin evolution.
title_short	The origins of novel protein interactions during animal opsin evolution.
title_full	The origins of novel protein interactions during animal opsin evolution.
title_fullStr	The origins of novel protein interactions during animal opsin evolution.
title_full_unstemmed	The origins of novel protein interactions during animal opsin evolution.
title_sort	origins of novel protein interactions during animal opsin evolution.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/92cd2a4c11674c67acde5e05d5f38c24
work_keys_str_mv	AT davidcplachetzki theoriginsofnovelproteininteractionsduringanimalopsinevolution AT bernardmdegnan theoriginsofnovelproteininteractionsduringanimalopsinevolution AT toddhoakley theoriginsofnovelproteininteractionsduringanimalopsinevolution AT davidcplachetzki originsofnovelproteininteractionsduringanimalopsinevolution AT bernardmdegnan originsofnovelproteininteractionsduringanimalopsinevolution AT toddhoakley originsofnovelproteininteractionsduringanimalopsinevolution
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The origins of novel protein interactions during animal opsin evolution.

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