TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

TGFβ has a role in cancer immunosuppression but the exact mechanisms haven’t been fully elucidated. Here, using mouse models deficient in TGFβ-signaling, the authors show that loss of ALK5 in CD8 + T cells enhances their tumour trafficking and cytotoxicity suggesting that ALK5 inhibitors may have cl...

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Autores principales:	Andrew J. Gunderson, Tomoko Yamazaki, Kayla McCarty, Nathaniel Fox, Michaela Phillips, Alejandro Alice, Tiffany Blair, Mark Whiteford, David O’Brien, Rehan Ahmad, Maria X. Kiely, Amanda Hayman, Todd Crocenzi, Michael J. Gough, Marka R. Crittenden, Kristina H. Young
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92cd3d69e07a4978a47fb444a91f3dc2
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spelling	oai:doaj.org-article:92cd3d69e07a4978a47fb444a91f3dc22021-12-02T15:37:12ZTGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking10.1038/s41467-020-15404-82041-1723https://doaj.org/article/92cd3d69e07a4978a47fb444a91f3dc22020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15404-8https://doaj.org/toc/2041-1723TGFβ has a role in cancer immunosuppression but the exact mechanisms haven’t been fully elucidated. Here, using mouse models deficient in TGFβ-signaling, the authors show that loss of ALK5 in CD8 + T cells enhances their tumour trafficking and cytotoxicity suggesting that ALK5 inhibitors may have clinical utility.Andrew J. GundersonTomoko YamazakiKayla McCartyNathaniel FoxMichaela PhillipsAlejandro AliceTiffany BlairMark WhitefordDavid O’BrienRehan AhmadMaria X. KielyAmanda HaymanTodd CrocenziMichael J. GoughMarka R. CrittendenKristina H. YoungNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew J. Gunderson Tomoko Yamazaki Kayla McCarty Nathaniel Fox Michaela Phillips Alejandro Alice Tiffany Blair Mark Whiteford David O’Brien Rehan Ahmad Maria X. Kiely Amanda Hayman Todd Crocenzi Michael J. Gough Marka R. Crittenden Kristina H. Young TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking
description	TGFβ has a role in cancer immunosuppression but the exact mechanisms haven’t been fully elucidated. Here, using mouse models deficient in TGFβ-signaling, the authors show that loss of ALK5 in CD8 + T cells enhances their tumour trafficking and cytotoxicity suggesting that ALK5 inhibitors may have clinical utility.
format	article
author	Andrew J. Gunderson Tomoko Yamazaki Kayla McCarty Nathaniel Fox Michaela Phillips Alejandro Alice Tiffany Blair Mark Whiteford David O’Brien Rehan Ahmad Maria X. Kiely Amanda Hayman Todd Crocenzi Michael J. Gough Marka R. Crittenden Kristina H. Young
author_facet	Andrew J. Gunderson Tomoko Yamazaki Kayla McCarty Nathaniel Fox Michaela Phillips Alejandro Alice Tiffany Blair Mark Whiteford David O’Brien Rehan Ahmad Maria X. Kiely Amanda Hayman Todd Crocenzi Michael J. Gough Marka R. Crittenden Kristina H. Young
author_sort	Andrew J. Gunderson
title	TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking
title_short	TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking
title_full	TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking
title_fullStr	TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking
title_full_unstemmed	TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking
title_sort	tgfβ suppresses cd8+ t cell expression of cxcr3 and tumor trafficking
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/92cd3d69e07a4978a47fb444a91f3dc2
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TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

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