Abnormal skin in toe webs is a marker for abnormal glucose metabolism. A cross-sectional survey among 1,849 adults in Finland

Abstract Diabetes is undiagnosed disease and easy screening tools for it are warranted. Because foot complications are usual in diabetes, we aimed to test hypothesis that skin abnormalities are found already from patients who are not aware of having diabetes, by studying the possible association bet...

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Autores principales:	Suvi-Päivikki Sinikumpu, Juha Auvinen, Jari Jokelainen, Laura Huilaja, Katri Puukka, Aimo Ruokonen, Sirkka Keinänen-Kiukaanniemi, Kaisa Tasanen, Markku Timonen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92cd566476264d469516621eec5cac03
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spelling	oai:doaj.org-article:92cd566476264d469516621eec5cac032021-12-02T16:06:06ZAbnormal skin in toe webs is a marker for abnormal glucose metabolism. A cross-sectional survey among 1,849 adults in Finland10.1038/s41598-017-09354-32045-2322https://doaj.org/article/92cd566476264d469516621eec5cac032017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09354-3https://doaj.org/toc/2045-2322Abstract Diabetes is undiagnosed disease and easy screening tools for it are warranted. Because foot complications are usual in diabetes, we aimed to test hypothesis that skin abnormalities are found already from patients who are not aware of having diabetes, by studying the possible association between unhealthy toe web skin and abnormal glucose metabolism. 1,849 cases without previously diagnosed diabetes participated to the 46-year follow-up study of the Northern Finland Birth Cohort. A skin investigation was performed for all, and abnormal skin findings in toe web spaces were taken as explanatory variables. Abnormal glucose tolerance was the main outcome and it was tested with an oral glucose tolerance test (OGTT), glycosylated haemoglobin fraction (HbA1c) Values are numbers (percentages) of sub and fasting blood glucose. The participants who had any abnormal skin findings in toe webs were associated with 2.5-fold (OR 2.5, 95% CI 1.3–4.9) and 6-fold (OR 6.2, 1.4–27.6) increased risk of having previously undiagnosed diabetes detected by a 2-hour OGTT and HbA1c, respectively. The predictive power of toe web findings was comparable with FINDRISC score. Abnormal skin findings in the toe webs show increased risk of occult diabetes, and may, thus serve as an additional sign of undiagnosed diabetes.Suvi-Päivikki SinikumpuJuha AuvinenJari JokelainenLaura HuilajaKatri PuukkaAimo RuokonenSirkka Keinänen-KiukaanniemiKaisa TasanenMarkku TimonenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Suvi-Päivikki Sinikumpu Juha Auvinen Jari Jokelainen Laura Huilaja Katri Puukka Aimo Ruokonen Sirkka Keinänen-Kiukaanniemi Kaisa Tasanen Markku Timonen Abnormal skin in toe webs is a marker for abnormal glucose metabolism. A cross-sectional survey among 1,849 adults in Finland
description	Abstract Diabetes is undiagnosed disease and easy screening tools for it are warranted. Because foot complications are usual in diabetes, we aimed to test hypothesis that skin abnormalities are found already from patients who are not aware of having diabetes, by studying the possible association between unhealthy toe web skin and abnormal glucose metabolism. 1,849 cases without previously diagnosed diabetes participated to the 46-year follow-up study of the Northern Finland Birth Cohort. A skin investigation was performed for all, and abnormal skin findings in toe web spaces were taken as explanatory variables. Abnormal glucose tolerance was the main outcome and it was tested with an oral glucose tolerance test (OGTT), glycosylated haemoglobin fraction (HbA1c) Values are numbers (percentages) of sub and fasting blood glucose. The participants who had any abnormal skin findings in toe webs were associated with 2.5-fold (OR 2.5, 95% CI 1.3–4.9) and 6-fold (OR 6.2, 1.4–27.6) increased risk of having previously undiagnosed diabetes detected by a 2-hour OGTT and HbA1c, respectively. The predictive power of toe web findings was comparable with FINDRISC score. Abnormal skin findings in the toe webs show increased risk of occult diabetes, and may, thus serve as an additional sign of undiagnosed diabetes.
format	article
author	Suvi-Päivikki Sinikumpu Juha Auvinen Jari Jokelainen Laura Huilaja Katri Puukka Aimo Ruokonen Sirkka Keinänen-Kiukaanniemi Kaisa Tasanen Markku Timonen
author_facet	Suvi-Päivikki Sinikumpu Juha Auvinen Jari Jokelainen Laura Huilaja Katri Puukka Aimo Ruokonen Sirkka Keinänen-Kiukaanniemi Kaisa Tasanen Markku Timonen
author_sort	Suvi-Päivikki Sinikumpu
title	Abnormal skin in toe webs is a marker for abnormal glucose metabolism. A cross-sectional survey among 1,849 adults in Finland
title_short	Abnormal skin in toe webs is a marker for abnormal glucose metabolism. A cross-sectional survey among 1,849 adults in Finland
title_full	Abnormal skin in toe webs is a marker for abnormal glucose metabolism. A cross-sectional survey among 1,849 adults in Finland
title_fullStr	Abnormal skin in toe webs is a marker for abnormal glucose metabolism. A cross-sectional survey among 1,849 adults in Finland
title_full_unstemmed	Abnormal skin in toe webs is a marker for abnormal glucose metabolism. A cross-sectional survey among 1,849 adults in Finland
title_sort	abnormal skin in toe webs is a marker for abnormal glucose metabolism. a cross-sectional survey among 1,849 adults in finland
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/92cd566476264d469516621eec5cac03
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Abnormal skin in toe webs is a marker for abnormal glucose metabolism. A cross-sectional survey among 1,849 adults in Finland

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