The pathogenesis of autism spectrum disorder

This manuscript reviews the mechanisms that contribute to the production of the autism spectrum disorder (ASD), especially the genetic and immunological components. Knowing the participating elements and mechanisms are essential to establish preventive measures and look for early markers. The ASD ca...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Beatriz Sanabria-Barradas, Libna S. Gallardo-Beatriz, José A. Palma-Jacinto, Ana L. Calderón-Garcidueñas
Formato:	article
Lenguaje:	EN
Publicado:	Permanyer 2021
Materias:	Autism. Pathogenesis. Risk factors. Immunology. Genetics. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/92cde541a34c453b9b820e8c4d47f402
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:92cde541a34c453b9b820e8c4d47f402
record_format	dspace
spelling	oai:doaj.org-article:92cde541a34c453b9b820e8c4d47f4022021-11-12T02:17:29ZThe pathogenesis of autism spectrum disorder10.24875/RMN.200001292604-6180https://doaj.org/article/92cde541a34c453b9b820e8c4d47f4022021-01-01T00:00:00Zhttps://www.revmexneurociencia.com/frame_esp.php?id=162https://doaj.org/toc/2604-6180This manuscript reviews the mechanisms that contribute to the production of the autism spectrum disorder (ASD), especially the genetic and immunological components. Knowing the participating elements and mechanisms are essential to establish preventive measures and look for early markers. The ASD can have subtle or devastating manifestations, and exerting immunomodulatory actions could be useful in the management of these patients. There seems to be different environmental insults that may act as triggers in genetically predisposed subjects; these insults can promote an inflammatory response in which interleukin-6 could participate actively at the level of neural stem cells and progenitors. The degree of involvement in neurogenesis and astrogenesis, and therefore, the observed clinical spectrum will depend on two facts that alter the neural circuits, including the brain region that loses proper input or output connectivity due to abnormal migration of a group of neurons, and the astrocytic survival. Beatriz Sanabria-BarradasLibna S. Gallardo-BeatrizJosé A. Palma-JacintoAna L. Calderón-GarcidueñasPermanyerarticleAutism. Pathogenesis. Risk factors. Immunology. Genetics.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENRevista Mexicana de Neurociencia, Vol 22, Iss 6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Autism. Pathogenesis. Risk factors. Immunology. Genetics. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Autism. Pathogenesis. Risk factors. Immunology. Genetics. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Beatriz Sanabria-Barradas Libna S. Gallardo-Beatriz José A. Palma-Jacinto Ana L. Calderón-Garcidueñas The pathogenesis of autism spectrum disorder
description	This manuscript reviews the mechanisms that contribute to the production of the autism spectrum disorder (ASD), especially the genetic and immunological components. Knowing the participating elements and mechanisms are essential to establish preventive measures and look for early markers. The ASD can have subtle or devastating manifestations, and exerting immunomodulatory actions could be useful in the management of these patients. There seems to be different environmental insults that may act as triggers in genetically predisposed subjects; these insults can promote an inflammatory response in which interleukin-6 could participate actively at the level of neural stem cells and progenitors. The degree of involvement in neurogenesis and astrogenesis, and therefore, the observed clinical spectrum will depend on two facts that alter the neural circuits, including the brain region that loses proper input or output connectivity due to abnormal migration of a group of neurons, and the astrocytic survival.
format	article
author	Beatriz Sanabria-Barradas Libna S. Gallardo-Beatriz José A. Palma-Jacinto Ana L. Calderón-Garcidueñas
author_facet	Beatriz Sanabria-Barradas Libna S. Gallardo-Beatriz José A. Palma-Jacinto Ana L. Calderón-Garcidueñas
author_sort	Beatriz Sanabria-Barradas
title	The pathogenesis of autism spectrum disorder
title_short	The pathogenesis of autism spectrum disorder
title_full	The pathogenesis of autism spectrum disorder
title_fullStr	The pathogenesis of autism spectrum disorder
title_full_unstemmed	The pathogenesis of autism spectrum disorder
title_sort	pathogenesis of autism spectrum disorder
publisher	Permanyer
publishDate	2021
url	https://doaj.org/article/92cde541a34c453b9b820e8c4d47f402
work_keys_str_mv	AT beatrizsanabriabarradas thepathogenesisofautismspectrumdisorder AT libnasgallardobeatriz thepathogenesisofautismspectrumdisorder AT joseapalmajacinto thepathogenesisofautismspectrumdisorder AT analcalderongarciduenas thepathogenesisofautismspectrumdisorder AT beatrizsanabriabarradas pathogenesisofautismspectrumdisorder AT libnasgallardobeatriz pathogenesisofautismspectrumdisorder AT joseapalmajacinto pathogenesisofautismspectrumdisorder AT analcalderongarciduenas pathogenesisofautismspectrumdisorder
_version_	1718431304569061376

The pathogenesis of autism spectrum disorder

Ejemplares similares