Pathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders

Hepcidin, a hormone regulating iron metabolism, has received attention for its role in the pathogenesis of dysregulations in carbohydrate metabolism. Hepcidin disorders in patients with diabetes mellitus are bi-directional: manifesting as iron overload syndrome in cases of decreased hepcidin product...

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Autores principales:	Tatiana V. Saprina, Anastasia P. Zima, Nadezhda N. Musina, Tatiana S. Prokhorenko, Alina V. Latypova, Natalia S. Shakhmanova, Svetlana V. Budeeva
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2018
Materias:	diabetes mellitus hepcidin anemia of chronic disease iron overload alzheimer disease parkinson disease Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/92cf2e1e55844409b21568bef874c7ff
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spelling	oai:doaj.org-article:92cf2e1e55844409b21568bef874c7ff2021-11-14T09:00:22ZPathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders2072-03512072-037810.14341/DM9378https://doaj.org/article/92cf2e1e55844409b21568bef874c7ff2018-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/9378https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Hepcidin, a hormone regulating iron metabolism, has received attention for its role in the pathogenesis of dysregulations in carbohydrate metabolism. Hepcidin disorders in patients with diabetes mellitus are bi-directional: manifesting as iron overload syndrome in cases of decreased hepcidin production and as anaemia of chronic disease in cases of hepcidin hypersecretion. However, till date, detailed analyses of mechanisms underlying hepcidin dysregulation have not been conducted nor have the interactions of ferrocinetic and carbohydrate-metabolic disorders been examined. An association between diabetes mellitus and neurodegenerative diseases as well as the role of iron metabolism in Alzheimer or Parkinson diseases is a subject of ongoing research. This review provides a summary of the current understanding of hepcidin regulation and its disorders in various diseases, including diabetes mellitus and neurodegenerative diseases. In addition, we provide an overview of the available therapies that address ferrocinetic disorders resulting from the dysregulation of hepcidin.Tatiana V. SaprinaAnastasia P. ZimaNadezhda N. MusinaTatiana S. ProkhorenkoAlina V. LatypovaNatalia S. ShakhmanovaSvetlana V. BudeevaEndocrinology Research Centrearticlediabetes mellitushepcidinanemia of chronic diseaseiron overloadalzheimer diseaseparkinson diseaseNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 21, Iss 6, Pp 506-512 (2018)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus hepcidin anemia of chronic disease iron overload alzheimer disease parkinson disease Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus hepcidin anemia of chronic disease iron overload alzheimer disease parkinson disease Nutritional diseases. Deficiency diseases RC620-627 Tatiana V. Saprina Anastasia P. Zima Nadezhda N. Musina Tatiana S. Prokhorenko Alina V. Latypova Natalia S. Shakhmanova Svetlana V. Budeeva Pathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders
description	Hepcidin, a hormone regulating iron metabolism, has received attention for its role in the pathogenesis of dysregulations in carbohydrate metabolism. Hepcidin disorders in patients with diabetes mellitus are bi-directional: manifesting as iron overload syndrome in cases of decreased hepcidin production and as anaemia of chronic disease in cases of hepcidin hypersecretion. However, till date, detailed analyses of mechanisms underlying hepcidin dysregulation have not been conducted nor have the interactions of ferrocinetic and carbohydrate-metabolic disorders been examined. An association between diabetes mellitus and neurodegenerative diseases as well as the role of iron metabolism in Alzheimer or Parkinson diseases is a subject of ongoing research. This review provides a summary of the current understanding of hepcidin regulation and its disorders in various diseases, including diabetes mellitus and neurodegenerative diseases. In addition, we provide an overview of the available therapies that address ferrocinetic disorders resulting from the dysregulation of hepcidin.
format	article
author	Tatiana V. Saprina Anastasia P. Zima Nadezhda N. Musina Tatiana S. Prokhorenko Alina V. Latypova Natalia S. Shakhmanova Svetlana V. Budeeva
author_facet	Tatiana V. Saprina Anastasia P. Zima Nadezhda N. Musina Tatiana S. Prokhorenko Alina V. Latypova Natalia S. Shakhmanova Svetlana V. Budeeva
author_sort	Tatiana V. Saprina
title	Pathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders
title_short	Pathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders
title_full	Pathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders
title_fullStr	Pathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders
title_full_unstemmed	Pathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders
title_sort	pathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders
publisher	Endocrinology Research Centre
publishDate	2018
url	https://doaj.org/article/92cf2e1e55844409b21568bef874c7ff
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Pathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders

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