CT perfusion for response evaluation after interventional ablation of hepatocellular carcinoma: a prospective study

Abstract Background Computed tomography (CT) perfusion was found to be useful in assessing treatment response in a variety of cancers through the evaluation in the arterial perfusion changes. We investigated the performance of CT perfusion parameters for assessment of hepatocellular carcinoma (HCC)...

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Autores principales:	Mohamed Fouad Osman, Islam H. Shawali, Lamiaa I. A. Metwally, Ahmed Hosni Kamel, Mohamed El Sherbiny Ibrahim
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	CT perfusion Hepatocellular carcinoma Intervention ablation Response Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/92d4ceacbc974b0d83b0545b63fa6d17
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spelling	oai:doaj.org-article:92d4ceacbc974b0d83b0545b63fa6d172021-11-28T12:23:24ZCT perfusion for response evaluation after interventional ablation of hepatocellular carcinoma: a prospective study10.1186/s43055-021-00660-52090-4762https://doaj.org/article/92d4ceacbc974b0d83b0545b63fa6d172021-11-01T00:00:00Zhttps://doi.org/10.1186/s43055-021-00660-5https://doaj.org/toc/2090-4762Abstract Background Computed tomography (CT) perfusion was found to be useful in assessing treatment response in a variety of cancers through the evaluation in the arterial perfusion changes. We investigated the performance of CT perfusion parameters for assessment of hepatocellular carcinoma (HCC) response to radiofrequency ablation (RFA) and trans-arterial chemoembolization (TACE). We conducted a prospective diagnostic test accuracy study that recruited 70 HCC patients who were scheduled to undergo TACE or RFA. For each dynamic CT scan acquisition, four single perfusion CT image maps were generated, including functional maps of blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface (PS). Results In TACE-treated lesions, the BV achieved a sensitivity and specific of 100% and 83.3%, at a cutoff level of ≤ 122 ml/min/100 gm, for responders. Likewise, at a cutoff level of > 10 s, transit time had a sensitivity of 90.5% and specificity of 100%. At a cutoff level of ≤ 14 ml/min/100 gm, the PS had a sensitivity of 100% and specificity of 83.33% for responders. In RFA-treated lesions, at a cutoff level of ≤ 170 ml/min/100 gm and ≤ 11 ml/100 gm, the BF and BV had a sensitivity of 100% and specificity 100%, respectively, for responders. At a cutoff level of ≤ 11 ml/min/100 gm, PS had a sensitivity 77.27% and specificity 80%. Conclusions The present study confirms the feasibility of CT perfusion for assessment of response to TACE and RFA among patients with HCC.Mohamed Fouad OsmanIslam H. ShawaliLamiaa I. A. MetwallyAhmed Hosni KamelMohamed El Sherbiny IbrahimSpringerOpenarticleCT perfusionHepatocellular carcinomaIntervention ablationResponseMedical physics. Medical radiology. Nuclear medicineR895-920ENThe Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CT perfusion Hepatocellular carcinoma Intervention ablation Response Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	CT perfusion Hepatocellular carcinoma Intervention ablation Response Medical physics. Medical radiology. Nuclear medicine R895-920 Mohamed Fouad Osman Islam H. Shawali Lamiaa I. A. Metwally Ahmed Hosni Kamel Mohamed El Sherbiny Ibrahim CT perfusion for response evaluation after interventional ablation of hepatocellular carcinoma: a prospective study
description	Abstract Background Computed tomography (CT) perfusion was found to be useful in assessing treatment response in a variety of cancers through the evaluation in the arterial perfusion changes. We investigated the performance of CT perfusion parameters for assessment of hepatocellular carcinoma (HCC) response to radiofrequency ablation (RFA) and trans-arterial chemoembolization (TACE). We conducted a prospective diagnostic test accuracy study that recruited 70 HCC patients who were scheduled to undergo TACE or RFA. For each dynamic CT scan acquisition, four single perfusion CT image maps were generated, including functional maps of blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface (PS). Results In TACE-treated lesions, the BV achieved a sensitivity and specific of 100% and 83.3%, at a cutoff level of ≤ 122 ml/min/100 gm, for responders. Likewise, at a cutoff level of > 10 s, transit time had a sensitivity of 90.5% and specificity of 100%. At a cutoff level of ≤ 14 ml/min/100 gm, the PS had a sensitivity of 100% and specificity of 83.33% for responders. In RFA-treated lesions, at a cutoff level of ≤ 170 ml/min/100 gm and ≤ 11 ml/100 gm, the BF and BV had a sensitivity of 100% and specificity 100%, respectively, for responders. At a cutoff level of ≤ 11 ml/min/100 gm, PS had a sensitivity 77.27% and specificity 80%. Conclusions The present study confirms the feasibility of CT perfusion for assessment of response to TACE and RFA among patients with HCC.
format	article
author	Mohamed Fouad Osman Islam H. Shawali Lamiaa I. A. Metwally Ahmed Hosni Kamel Mohamed El Sherbiny Ibrahim
author_facet	Mohamed Fouad Osman Islam H. Shawali Lamiaa I. A. Metwally Ahmed Hosni Kamel Mohamed El Sherbiny Ibrahim
author_sort	Mohamed Fouad Osman
title	CT perfusion for response evaluation after interventional ablation of hepatocellular carcinoma: a prospective study
title_short	CT perfusion for response evaluation after interventional ablation of hepatocellular carcinoma: a prospective study
title_full	CT perfusion for response evaluation after interventional ablation of hepatocellular carcinoma: a prospective study
title_fullStr	CT perfusion for response evaluation after interventional ablation of hepatocellular carcinoma: a prospective study
title_full_unstemmed	CT perfusion for response evaluation after interventional ablation of hepatocellular carcinoma: a prospective study
title_sort	ct perfusion for response evaluation after interventional ablation of hepatocellular carcinoma: a prospective study
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/92d4ceacbc974b0d83b0545b63fa6d17
work_keys_str_mv	AT mohamedfouadosman ctperfusionforresponseevaluationafterinterventionalablationofhepatocellularcarcinomaaprospectivestudy AT islamhshawali ctperfusionforresponseevaluationafterinterventionalablationofhepatocellularcarcinomaaprospectivestudy AT lamiaaiametwally ctperfusionforresponseevaluationafterinterventionalablationofhepatocellularcarcinomaaprospectivestudy AT ahmedhosnikamel ctperfusionforresponseevaluationafterinterventionalablationofhepatocellularcarcinomaaprospectivestudy AT mohamedelsherbinyibrahim ctperfusionforresponseevaluationafterinterventionalablationofhepatocellularcarcinomaaprospectivestudy
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CT perfusion for response evaluation after interventional ablation of hepatocellular carcinoma: a prospective study

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