Dynamic interaction of cBid with detergents, liposomes and mitochondria.

The BH3-only protein Bid plays a key role in the induction of mitochondrial apoptosis, but its mechanism of action is still not completely understood. Here we studied the two main activation events of Bid: Caspase-8 cleavage and interaction with the membrane bilayer. We found a striking reversible b...

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Autores principales: Stephanie Bleicken, Ana J García-Sáez, Elena Conte, Enrica Bordignon
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/92d5f3e0136b4761b23ae1f6a761cb6c
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