Risk of death from cardiovascular disease following breast cancer in Southeast Asia: a prospective cohort study

Abstract Breast cancer incidence and survival is high in Southeast Asia. As such, many women diagnosed with breast cancer are at risk of dying of other causes. Given the increased risk of cardiotoxicity induced by breast cancer treatments, it is important to identify patients at high risk of cardiov...

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Autores principales:	S. A. M. Gernaat, P. J. Ho, N. Rijnberg, S. C. Lee, S. H. Lim, Y. S. Yap, D. E. Grobbee, M. Hartman, H. M. Verkooijen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92d603e813fc41ce82679849aaba7ae6
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spelling	oai:doaj.org-article:92d603e813fc41ce82679849aaba7ae62021-12-02T16:06:06ZRisk of death from cardiovascular disease following breast cancer in Southeast Asia: a prospective cohort study10.1038/s41598-017-01540-72045-2322https://doaj.org/article/92d603e813fc41ce82679849aaba7ae62017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01540-7https://doaj.org/toc/2045-2322Abstract Breast cancer incidence and survival is high in Southeast Asia. As such, many women diagnosed with breast cancer are at risk of dying of other causes. Given the increased risk of cardiotoxicity induced by breast cancer treatments, it is important to identify patients at high risk of cardiovascular disease (CVD) mortality. The aim of this study was to investigate if this risk varies by age and ethnicity. Patient details were obtained from 5,868 Chinese, Malay, and Indian women diagnosed with in situ or non-metastasized invasive breast cancer at the National University Hospital of Singapore and KK Women’s and Children’s Hospital in Singapore. Death causes were obtained from the National Registry of Births and Deaths. Flexible parametric survival models estimated CVD mortality rates and hazard ratios. During a median follow-up of six years, 1,010 deaths occurred of which 6.8% were due to CVD. CVD mortality rates of older women peaked within the first year following diagnosis and increased over time since diagnosis. Indian had more than double the risk of CVD mortality than Chinese, independent of age at diagnosis and stage. Taking ethnicity and age into account may promote CVD risk stratification and management in (Southeast Asian) women with breast cancer.S. A. M. GernaatP. J. HoN. RijnbergS. C. LeeS. H. LimY. S. YapD. E. GrobbeeM. HartmanH. M. VerkooijenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q S. A. M. Gernaat P. J. Ho N. Rijnberg S. C. Lee S. H. Lim Y. S. Yap D. E. Grobbee M. Hartman H. M. Verkooijen Risk of death from cardiovascular disease following breast cancer in Southeast Asia: a prospective cohort study
description	Abstract Breast cancer incidence and survival is high in Southeast Asia. As such, many women diagnosed with breast cancer are at risk of dying of other causes. Given the increased risk of cardiotoxicity induced by breast cancer treatments, it is important to identify patients at high risk of cardiovascular disease (CVD) mortality. The aim of this study was to investigate if this risk varies by age and ethnicity. Patient details were obtained from 5,868 Chinese, Malay, and Indian women diagnosed with in situ or non-metastasized invasive breast cancer at the National University Hospital of Singapore and KK Women’s and Children’s Hospital in Singapore. Death causes were obtained from the National Registry of Births and Deaths. Flexible parametric survival models estimated CVD mortality rates and hazard ratios. During a median follow-up of six years, 1,010 deaths occurred of which 6.8% were due to CVD. CVD mortality rates of older women peaked within the first year following diagnosis and increased over time since diagnosis. Indian had more than double the risk of CVD mortality than Chinese, independent of age at diagnosis and stage. Taking ethnicity and age into account may promote CVD risk stratification and management in (Southeast Asian) women with breast cancer.
format	article
author	S. A. M. Gernaat P. J. Ho N. Rijnberg S. C. Lee S. H. Lim Y. S. Yap D. E. Grobbee M. Hartman H. M. Verkooijen
author_facet	S. A. M. Gernaat P. J. Ho N. Rijnberg S. C. Lee S. H. Lim Y. S. Yap D. E. Grobbee M. Hartman H. M. Verkooijen
author_sort	S. A. M. Gernaat
title	Risk of death from cardiovascular disease following breast cancer in Southeast Asia: a prospective cohort study
title_short	Risk of death from cardiovascular disease following breast cancer in Southeast Asia: a prospective cohort study
title_full	Risk of death from cardiovascular disease following breast cancer in Southeast Asia: a prospective cohort study
title_fullStr	Risk of death from cardiovascular disease following breast cancer in Southeast Asia: a prospective cohort study
title_full_unstemmed	Risk of death from cardiovascular disease following breast cancer in Southeast Asia: a prospective cohort study
title_sort	risk of death from cardiovascular disease following breast cancer in southeast asia: a prospective cohort study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/92d603e813fc41ce82679849aaba7ae6
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_version_	1718385102226980864

Risk of death from cardiovascular disease following breast cancer in Southeast Asia: a prospective cohort study

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