Impact of Fatty Pancreas on Postoperative Pancreatic Fistulae: A Meta-Analysis

BackgroundSoft pancreas is widely recognized as an important risk factor for the development of postoperative pancreatic fistula (POPF). Although fatty pancreas (FP) has not been formally defined as a cause of pancreatic fistula, existing research has shown that it can increase the incidence of POPF...

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Autores principales:	Lu Zhou, Wei-ming Xiao, Cheng-peng Li, Yi-wen Gao, Wei-juan Gong, Guo-tao Lu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pancrea BMI - Body Mass Index fatty pancreas pancreatic cancer pancreatic fistula (PF) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/92d6caad83ee4de5a982cfb5ee0920f1
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spelling	oai:doaj.org-article:92d6caad83ee4de5a982cfb5ee0920f12021-12-01T23:57:47ZImpact of Fatty Pancreas on Postoperative Pancreatic Fistulae: A Meta-Analysis2234-943X10.3389/fonc.2021.622282https://doaj.org/article/92d6caad83ee4de5a982cfb5ee0920f12021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.622282/fullhttps://doaj.org/toc/2234-943XBackgroundSoft pancreas is widely recognized as an important risk factor for the development of postoperative pancreatic fistula (POPF). Although fatty pancreas (FP) has not been formally defined as a cause of pancreatic fistula, existing research has shown that it can increase the incidence of POPF by increasing pancreatic tenderness; therefore, it may be a potential risk factor. This study aimed to discern whether FP was associated with POPF.MethodTwo reviewers independently performed literature searches from five electronic databases. According to the established inclusion criteria, we extracted necessary data from the studies that met the criteria for further analysis. We pooled the odds ratios (ORs) from individual studies using a random-effects model to investigate the associations between POPF and the prognosis of FP.ResultA total of 11 studies involving 2484 individuals were included. The pooled prevalence of POPF was 18% (95% CI: 12-24%). Body mass index (BMI) was associated with a significantly increased risk of POPF (OR=3.55; 95% CI: 1.83, 6.86; P=0.0002; I²=0). FP was obviously associated with the occurrence of POPF (OR=3.75; 95% CI: 1.64, 8.58; P=0.002; I²=78).ConclusionFP is closely associated with the development of POPF, and the early identification of these high-risk patients can help to reduce the incidence of POPF.Systematic Review RegistrationThe Registration URL link is (https://www.crd.york.ac.uk/PROSPERO/). The ID is “CRD42021265141”.Lu ZhouLu ZhouWei-ming XiaoWei-ming XiaoCheng-peng LiYi-wen GaoYi-wen GaoWei-juan GongWei-juan GongGuo-tao LuGuo-tao LuFrontiers Media S.A.articlepancreaBMI - Body Mass Indexfatty pancreaspancreatic cancerpancreatic fistula (PF)Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pancrea BMI - Body Mass Index fatty pancreas pancreatic cancer pancreatic fistula (PF) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	pancrea BMI - Body Mass Index fatty pancreas pancreatic cancer pancreatic fistula (PF) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Lu Zhou Lu Zhou Wei-ming Xiao Wei-ming Xiao Cheng-peng Li Yi-wen Gao Yi-wen Gao Wei-juan Gong Wei-juan Gong Guo-tao Lu Guo-tao Lu Impact of Fatty Pancreas on Postoperative Pancreatic Fistulae: A Meta-Analysis
description	BackgroundSoft pancreas is widely recognized as an important risk factor for the development of postoperative pancreatic fistula (POPF). Although fatty pancreas (FP) has not been formally defined as a cause of pancreatic fistula, existing research has shown that it can increase the incidence of POPF by increasing pancreatic tenderness; therefore, it may be a potential risk factor. This study aimed to discern whether FP was associated with POPF.MethodTwo reviewers independently performed literature searches from five electronic databases. According to the established inclusion criteria, we extracted necessary data from the studies that met the criteria for further analysis. We pooled the odds ratios (ORs) from individual studies using a random-effects model to investigate the associations between POPF and the prognosis of FP.ResultA total of 11 studies involving 2484 individuals were included. The pooled prevalence of POPF was 18% (95% CI: 12-24%). Body mass index (BMI) was associated with a significantly increased risk of POPF (OR=3.55; 95% CI: 1.83, 6.86; P=0.0002; I²=0). FP was obviously associated with the occurrence of POPF (OR=3.75; 95% CI: 1.64, 8.58; P=0.002; I²=78).ConclusionFP is closely associated with the development of POPF, and the early identification of these high-risk patients can help to reduce the incidence of POPF.Systematic Review RegistrationThe Registration URL link is (https://www.crd.york.ac.uk/PROSPERO/). The ID is “CRD42021265141”.
format	article
author	Lu Zhou Lu Zhou Wei-ming Xiao Wei-ming Xiao Cheng-peng Li Yi-wen Gao Yi-wen Gao Wei-juan Gong Wei-juan Gong Guo-tao Lu Guo-tao Lu
author_facet	Lu Zhou Lu Zhou Wei-ming Xiao Wei-ming Xiao Cheng-peng Li Yi-wen Gao Yi-wen Gao Wei-juan Gong Wei-juan Gong Guo-tao Lu Guo-tao Lu
author_sort	Lu Zhou
title	Impact of Fatty Pancreas on Postoperative Pancreatic Fistulae: A Meta-Analysis
title_short	Impact of Fatty Pancreas on Postoperative Pancreatic Fistulae: A Meta-Analysis
title_full	Impact of Fatty Pancreas on Postoperative Pancreatic Fistulae: A Meta-Analysis
title_fullStr	Impact of Fatty Pancreas on Postoperative Pancreatic Fistulae: A Meta-Analysis
title_full_unstemmed	Impact of Fatty Pancreas on Postoperative Pancreatic Fistulae: A Meta-Analysis
title_sort	impact of fatty pancreas on postoperative pancreatic fistulae: a meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/92d6caad83ee4de5a982cfb5ee0920f1
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Impact of Fatty Pancreas on Postoperative Pancreatic Fistulae: A Meta-Analysis

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