Mediterranean diet, telomere maintenance and health status among elderly.

Leukocyte telomere length (LTL) and rate of telomere shortening are known biomarkers of aging while, numerous studies showed that Mediterranean diet (MD) may boost longevity. We studied association between telomere length, telomerase activity and different adherence to MD and its effects on healthy...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Virginia Boccardi, Antonietta Esposito, Maria Rosaria Rizzo, Raffaele Marfella, Michelangela Barbieri, Giuseppe Paolisso
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92db324fbf564a108a2f1e7b49efe257
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:92db324fbf564a108a2f1e7b49efe257
record_format	dspace
spelling	oai:doaj.org-article:92db324fbf564a108a2f1e7b49efe2572021-11-18T07:47:23ZMediterranean diet, telomere maintenance and health status among elderly.1932-620310.1371/journal.pone.0062781https://doaj.org/article/92db324fbf564a108a2f1e7b49efe2572013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23646142/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Leukocyte telomere length (LTL) and rate of telomere shortening are known biomarkers of aging while, numerous studies showed that Mediterranean diet (MD) may boost longevity. We studied association between telomere length, telomerase activity and different adherence to MD and its effects on healthy status. The study was conducted in 217 elderly subjects stratified according Mediterranean diet score (MDS) in low adherence (MDS≤3), medium adherence (MDS 4-5) and high adherence (MDS≥6) groups. LTL was measured by quantitative polymerase chain reaction and telomerase activity by a PCR-ELISA protocol. High adherence group showed longer LTL (p = 0.003) and higher telomerase activity (p = 0.013) compared to others. Linear regression analysis including age, gender, smoking habit and MDS showed that MDS was independently associated with LTL (p = 0.024) and telomerase activity levels (p = 0.006). Telomerase activity was independently associated with LTL (p = 0.007) and negatively modulated by inflammation and oxidative stress. Indeed, telomerase levels were associated with healthy status independently of multiple covariates (p = 0.048). These results support a novel role of MD in promoting health-span suggesting that telomere maintenance, rather than LTL variability is the major determinant of healthy status among elderly.Virginia BoccardiAntonietta EspositoMaria Rosaria RizzoRaffaele MarfellaMichelangela BarbieriGiuseppe PaolissoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e62781 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Virginia Boccardi Antonietta Esposito Maria Rosaria Rizzo Raffaele Marfella Michelangela Barbieri Giuseppe Paolisso Mediterranean diet, telomere maintenance and health status among elderly.
description	Leukocyte telomere length (LTL) and rate of telomere shortening are known biomarkers of aging while, numerous studies showed that Mediterranean diet (MD) may boost longevity. We studied association between telomere length, telomerase activity and different adherence to MD and its effects on healthy status. The study was conducted in 217 elderly subjects stratified according Mediterranean diet score (MDS) in low adherence (MDS≤3), medium adherence (MDS 4-5) and high adherence (MDS≥6) groups. LTL was measured by quantitative polymerase chain reaction and telomerase activity by a PCR-ELISA protocol. High adherence group showed longer LTL (p = 0.003) and higher telomerase activity (p = 0.013) compared to others. Linear regression analysis including age, gender, smoking habit and MDS showed that MDS was independently associated with LTL (p = 0.024) and telomerase activity levels (p = 0.006). Telomerase activity was independently associated with LTL (p = 0.007) and negatively modulated by inflammation and oxidative stress. Indeed, telomerase levels were associated with healthy status independently of multiple covariates (p = 0.048). These results support a novel role of MD in promoting health-span suggesting that telomere maintenance, rather than LTL variability is the major determinant of healthy status among elderly.
format	article
author	Virginia Boccardi Antonietta Esposito Maria Rosaria Rizzo Raffaele Marfella Michelangela Barbieri Giuseppe Paolisso
author_facet	Virginia Boccardi Antonietta Esposito Maria Rosaria Rizzo Raffaele Marfella Michelangela Barbieri Giuseppe Paolisso
author_sort	Virginia Boccardi
title	Mediterranean diet, telomere maintenance and health status among elderly.
title_short	Mediterranean diet, telomere maintenance and health status among elderly.
title_full	Mediterranean diet, telomere maintenance and health status among elderly.
title_fullStr	Mediterranean diet, telomere maintenance and health status among elderly.
title_full_unstemmed	Mediterranean diet, telomere maintenance and health status among elderly.
title_sort	mediterranean diet, telomere maintenance and health status among elderly.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/92db324fbf564a108a2f1e7b49efe257
work_keys_str_mv	AT virginiaboccardi mediterraneandiettelomeremaintenanceandhealthstatusamongelderly AT antoniettaesposito mediterraneandiettelomeremaintenanceandhealthstatusamongelderly AT mariarosariarizzo mediterraneandiettelomeremaintenanceandhealthstatusamongelderly AT raffaelemarfella mediterraneandiettelomeremaintenanceandhealthstatusamongelderly AT michelangelabarbieri mediterraneandiettelomeremaintenanceandhealthstatusamongelderly AT giuseppepaolisso mediterraneandiettelomeremaintenanceandhealthstatusamongelderly
_version_	1718422987816828928

Mediterranean diet, telomere maintenance and health status among elderly.

Ejemplares similares