A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry

The Na+/H+ exchanger NHE9 is proposed to regulate the H+ electrochemical gradient across endosomal membranes. Here, the authors find that NHE9 knockout mice show autism spectrum disorder-like behaviors and disrupted synaptic vesicle exocytosis due to impaired presynaptic calcium entry.

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Detalles Bibliográficos
Autores principales: Julie C. Ullman, Jing Yang, Michael Sullivan, Jacob Bendor, Jonathan Levy, Ellen Pham, Katlin Silm, Helia Seifikar, Vikaas S. Sohal, Roger A. Nicoll, Robert H. Edwards
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
Q
Acceso en línea:https://doaj.org/article/92e65f596eb44f879ff6c2b988a111c2
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