Postpartum ovulation and early pregnancy in the menstruating spiny mouse, Acomys cahirinus

Abstract Egyptian spiny mice are the only known species to have human-like menstruation and a postpartum ovulation. Unfortunately, no endocrine or morphological evidence has been provided for a postpartum ovulation in spiny mice, and while later stages of pregnancy have been well studied, early even...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jarrod McKenna, Nadia Bellofiore, Evdokia Dimitriadis, Peter Temple-Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92e8ae01e43a4bb9b82149fd5a50a94d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:92e8ae01e43a4bb9b82149fd5a50a94d
record_format	dspace
spelling	oai:doaj.org-article:92e8ae01e43a4bb9b82149fd5a50a94d2021-12-02T13:30:11ZPostpartum ovulation and early pregnancy in the menstruating spiny mouse, Acomys cahirinus10.1038/s41598-021-84361-z2045-2322https://doaj.org/article/92e8ae01e43a4bb9b82149fd5a50a94d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84361-zhttps://doaj.org/toc/2045-2322Abstract Egyptian spiny mice are the only known species to have human-like menstruation and a postpartum ovulation. Unfortunately, no endocrine or morphological evidence has been provided for a postpartum ovulation in spiny mice, and while later stages of pregnancy have been well studied, early events including embryo implantation and spiral artery remodelling have not been reported. This study compared the sex steroid endocrinology and reproductive tract morphology of dams at eight timepoints (n = 40) postpartum to determine the timing of ovulation and the timing and invasiveness of embryo implantation in A. cahirinus. Reproductive tracts were fixed and stained for histology and immunohistochemistry, and plasma was prepared for enzyme-linked immunosorbent assay. Ovarian histology and estradiol-17B concentrations indicate ovulation within 48 h of parturition and then immediate resumption of follicular growth. Uterine histology and immunohistochemistry revealed progressive epithelial repair, endometrial growth and spiral artery assembly and remodelling in dams postpartum. Blastocysts were seen in the uterine lumen at day 4–5 postpartum and embryos had implanted superficially with minimal stromal invasion by day 5–6. This study provides further evidence for the unique, humanesque reproductive biology of spiny mice and for a postpartum ovulation using endocrine and morphological changes observed during early pregnancy. Taken together, our data suggest that spiny mice may act as appropriate models of human pregnancy disorders such as implantation failure or pre-eclampsia.Jarrod McKennaNadia BellofioreEvdokia DimitriadisPeter Temple-SmithNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jarrod McKenna Nadia Bellofiore Evdokia Dimitriadis Peter Temple-Smith Postpartum ovulation and early pregnancy in the menstruating spiny mouse, Acomys cahirinus
description	Abstract Egyptian spiny mice are the only known species to have human-like menstruation and a postpartum ovulation. Unfortunately, no endocrine or morphological evidence has been provided for a postpartum ovulation in spiny mice, and while later stages of pregnancy have been well studied, early events including embryo implantation and spiral artery remodelling have not been reported. This study compared the sex steroid endocrinology and reproductive tract morphology of dams at eight timepoints (n = 40) postpartum to determine the timing of ovulation and the timing and invasiveness of embryo implantation in A. cahirinus. Reproductive tracts were fixed and stained for histology and immunohistochemistry, and plasma was prepared for enzyme-linked immunosorbent assay. Ovarian histology and estradiol-17B concentrations indicate ovulation within 48 h of parturition and then immediate resumption of follicular growth. Uterine histology and immunohistochemistry revealed progressive epithelial repair, endometrial growth and spiral artery assembly and remodelling in dams postpartum. Blastocysts were seen in the uterine lumen at day 4–5 postpartum and embryos had implanted superficially with minimal stromal invasion by day 5–6. This study provides further evidence for the unique, humanesque reproductive biology of spiny mice and for a postpartum ovulation using endocrine and morphological changes observed during early pregnancy. Taken together, our data suggest that spiny mice may act as appropriate models of human pregnancy disorders such as implantation failure or pre-eclampsia.
format	article
author	Jarrod McKenna Nadia Bellofiore Evdokia Dimitriadis Peter Temple-Smith
author_facet	Jarrod McKenna Nadia Bellofiore Evdokia Dimitriadis Peter Temple-Smith
author_sort	Jarrod McKenna
title	Postpartum ovulation and early pregnancy in the menstruating spiny mouse, Acomys cahirinus
title_short	Postpartum ovulation and early pregnancy in the menstruating spiny mouse, Acomys cahirinus
title_full	Postpartum ovulation and early pregnancy in the menstruating spiny mouse, Acomys cahirinus
title_fullStr	Postpartum ovulation and early pregnancy in the menstruating spiny mouse, Acomys cahirinus
title_full_unstemmed	Postpartum ovulation and early pregnancy in the menstruating spiny mouse, Acomys cahirinus
title_sort	postpartum ovulation and early pregnancy in the menstruating spiny mouse, acomys cahirinus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/92e8ae01e43a4bb9b82149fd5a50a94d
work_keys_str_mv	AT jarrodmckenna postpartumovulationandearlypregnancyinthemenstruatingspinymouseacomyscahirinus AT nadiabellofiore postpartumovulationandearlypregnancyinthemenstruatingspinymouseacomyscahirinus AT evdokiadimitriadis postpartumovulationandearlypregnancyinthemenstruatingspinymouseacomyscahirinus AT petertemplesmith postpartumovulationandearlypregnancyinthemenstruatingspinymouseacomyscahirinus
_version_	1718392989226631168

Postpartum ovulation and early pregnancy in the menstruating spiny mouse, Acomys cahirinus

Ejemplares similares