Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy

For years, surgery, radiotherapy, and chemotherapy have been the gold standards to treat cancer, although continuing research has sought a more effective approach. While advances can be seen in the development of anticancer drugs, the tools that can improve their delivery remain a challenge. As anti...

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Autores principales:	Anna Florczak, Tomasz Deptuch, Kamil Kucharczyk, Hanna Dams-Kozlowska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	silk fibroin spidroin sericin local drug delivery systemic drug delivery cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/92e8c046650e4d83be5ac26e9e87bc73
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spelling	oai:doaj.org-article:92e8c046650e4d83be5ac26e9e87bc732021-11-11T15:29:51ZSystemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy10.3390/cancers132153892072-6694https://doaj.org/article/92e8c046650e4d83be5ac26e9e87bc732021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5389https://doaj.org/toc/2072-6694For years, surgery, radiotherapy, and chemotherapy have been the gold standards to treat cancer, although continuing research has sought a more effective approach. While advances can be seen in the development of anticancer drugs, the tools that can improve their delivery remain a challenge. As anticancer drugs can affect the entire body, the control of their distribution is desirable to prevent systemic toxicity. The application of a suitable drug delivery platform may resolve this problem. Among other materials, silks offer many advantageous properties, including biodegradability, biocompatibility, and the possibility of obtaining a variety of morphological structures. These characteristics allow the exploration of silk for biomedical applications and as a platform for drug delivery. We have reviewed silk structures that can be used for local and systemic drug delivery for use in cancer therapy. After a short description of the most studied silks, we discuss the advantages of using silk for drug delivery. The tables summarize the descriptions of silk structures for the local and systemic transport of anticancer drugs. The most popular techniques for silk particle preparation are presented. Further prospects for using silk as a drug carrier are considered. The application of various silk biomaterials can improve cancer treatment by the controllable delivery of chemotherapeutics, immunotherapeutics, photosensitizers, hormones, nucleotherapeutics, targeted therapeutics (e.g., kinase inhibitors), and inorganic nanoparticles, among others.Anna FlorczakTomasz DeptuchKamil KucharczykHanna Dams-KozlowskaMDPI AGarticlesilk fibroinspidroinsericinlocal drug deliverysystemic drug deliverycancer therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5389, p 5389 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	silk fibroin spidroin sericin local drug delivery systemic drug delivery cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	silk fibroin spidroin sericin local drug delivery systemic drug delivery cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Anna Florczak Tomasz Deptuch Kamil Kucharczyk Hanna Dams-Kozlowska Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy
description	For years, surgery, radiotherapy, and chemotherapy have been the gold standards to treat cancer, although continuing research has sought a more effective approach. While advances can be seen in the development of anticancer drugs, the tools that can improve their delivery remain a challenge. As anticancer drugs can affect the entire body, the control of their distribution is desirable to prevent systemic toxicity. The application of a suitable drug delivery platform may resolve this problem. Among other materials, silks offer many advantageous properties, including biodegradability, biocompatibility, and the possibility of obtaining a variety of morphological structures. These characteristics allow the exploration of silk for biomedical applications and as a platform for drug delivery. We have reviewed silk structures that can be used for local and systemic drug delivery for use in cancer therapy. After a short description of the most studied silks, we discuss the advantages of using silk for drug delivery. The tables summarize the descriptions of silk structures for the local and systemic transport of anticancer drugs. The most popular techniques for silk particle preparation are presented. Further prospects for using silk as a drug carrier are considered. The application of various silk biomaterials can improve cancer treatment by the controllable delivery of chemotherapeutics, immunotherapeutics, photosensitizers, hormones, nucleotherapeutics, targeted therapeutics (e.g., kinase inhibitors), and inorganic nanoparticles, among others.
format	article
author	Anna Florczak Tomasz Deptuch Kamil Kucharczyk Hanna Dams-Kozlowska
author_facet	Anna Florczak Tomasz Deptuch Kamil Kucharczyk Hanna Dams-Kozlowska
author_sort	Anna Florczak
title	Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy
title_short	Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy
title_full	Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy
title_fullStr	Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy
title_full_unstemmed	Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy
title_sort	systemic and local silk-based drug delivery systems for cancer therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/92e8c046650e4d83be5ac26e9e87bc73
work_keys_str_mv	AT annaflorczak systemicandlocalsilkbaseddrugdeliverysystemsforcancertherapy AT tomaszdeptuch systemicandlocalsilkbaseddrugdeliverysystemsforcancertherapy AT kamilkucharczyk systemicandlocalsilkbaseddrugdeliverysystemsforcancertherapy AT hannadamskozlowska systemicandlocalsilkbaseddrugdeliverysystemsforcancertherapy
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Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy

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