Changes in each retinal layer and ellipsoid zone recovery after full-thickness macular hole surgery

Abstract To analyze the changes in each retinal layer and the recovery of the ellipsoid zone (EZ) after full-thickness macular hole (FTMH) surgery. Patients who underwent surgery for FTMH were included. Spectral-domain optical coherence tomography (SD-OCT) was performed preoperatively and postoperat...

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Autores principales:	Min-Woo Lee, Tae-Yeon Kim, Yong-Yeon Song, Seung-Kook Baek, Young-Hoon Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92e96e86c7e44ed6a07ded41528b5cbd
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spelling	oai:doaj.org-article:92e96e86c7e44ed6a07ded41528b5cbd2021-12-02T17:51:21ZChanges in each retinal layer and ellipsoid zone recovery after full-thickness macular hole surgery10.1038/s41598-021-90955-42045-2322https://doaj.org/article/92e96e86c7e44ed6a07ded41528b5cbd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90955-4https://doaj.org/toc/2045-2322Abstract To analyze the changes in each retinal layer and the recovery of the ellipsoid zone (EZ) after full-thickness macular hole (FTMH) surgery. Patients who underwent surgery for FTMH were included. Spectral-domain optical coherence tomography (SD-OCT) was performed preoperatively and postoperatively at 1, 3, 6, 9, and 12 months. A total of 32 eyes were enrolled. Ganglion cell layer, inner plexiform layer, and inner nuclear layer showed significant reductions over time after surgery (P = 0.020, P = 0.001, and P = 0.001, respectively), but were significantly thicker than those of fellow eyes at 12 months postoperatively. The average recovery duration of the external limiting membrane (ELM), outer nuclear layer (ONL), and EZ was 1.5, 2.1, and 6.1 months, respectively. Baseline best-corrected visual acuity (BCVA) (P = 0.003), minimum linear diameter (MLD) (P = 0.025), recovery of EZ (P = 0.008), and IRL thickness (P < 0.001) were significant factors associated with changes in the BCVA. Additionally, axial length (P < 0.001), MLD (P = 0.020), and IRL thickness (P = 0.001) showed significant results associated with EZ recovery. The IRL gradually became thinner after FTMH surgery but was still thicker than that of the fellow eye at 12 months postoperatively. The recovery of ELM and ONL may be a prerequisite for the EZ recovery. The BCVA change was affected by baseline BCVA, MLD, recovery of EZ, and IRL thickness. Additionally, axial length, MLD, and IRL thickness were significantly associated with EZ recovery.Min-Woo LeeTae-Yeon KimYong-Yeon SongSeung-Kook BaekYoung-Hoon LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min-Woo Lee Tae-Yeon Kim Yong-Yeon Song Seung-Kook Baek Young-Hoon Lee Changes in each retinal layer and ellipsoid zone recovery after full-thickness macular hole surgery
description	Abstract To analyze the changes in each retinal layer and the recovery of the ellipsoid zone (EZ) after full-thickness macular hole (FTMH) surgery. Patients who underwent surgery for FTMH were included. Spectral-domain optical coherence tomography (SD-OCT) was performed preoperatively and postoperatively at 1, 3, 6, 9, and 12 months. A total of 32 eyes were enrolled. Ganglion cell layer, inner plexiform layer, and inner nuclear layer showed significant reductions over time after surgery (P = 0.020, P = 0.001, and P = 0.001, respectively), but were significantly thicker than those of fellow eyes at 12 months postoperatively. The average recovery duration of the external limiting membrane (ELM), outer nuclear layer (ONL), and EZ was 1.5, 2.1, and 6.1 months, respectively. Baseline best-corrected visual acuity (BCVA) (P = 0.003), minimum linear diameter (MLD) (P = 0.025), recovery of EZ (P = 0.008), and IRL thickness (P < 0.001) were significant factors associated with changes in the BCVA. Additionally, axial length (P < 0.001), MLD (P = 0.020), and IRL thickness (P = 0.001) showed significant results associated with EZ recovery. The IRL gradually became thinner after FTMH surgery but was still thicker than that of the fellow eye at 12 months postoperatively. The recovery of ELM and ONL may be a prerequisite for the EZ recovery. The BCVA change was affected by baseline BCVA, MLD, recovery of EZ, and IRL thickness. Additionally, axial length, MLD, and IRL thickness were significantly associated with EZ recovery.
format	article
author	Min-Woo Lee Tae-Yeon Kim Yong-Yeon Song Seung-Kook Baek Young-Hoon Lee
author_facet	Min-Woo Lee Tae-Yeon Kim Yong-Yeon Song Seung-Kook Baek Young-Hoon Lee
author_sort	Min-Woo Lee
title	Changes in each retinal layer and ellipsoid zone recovery after full-thickness macular hole surgery
title_short	Changes in each retinal layer and ellipsoid zone recovery after full-thickness macular hole surgery
title_full	Changes in each retinal layer and ellipsoid zone recovery after full-thickness macular hole surgery
title_fullStr	Changes in each retinal layer and ellipsoid zone recovery after full-thickness macular hole surgery
title_full_unstemmed	Changes in each retinal layer and ellipsoid zone recovery after full-thickness macular hole surgery
title_sort	changes in each retinal layer and ellipsoid zone recovery after full-thickness macular hole surgery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/92e96e86c7e44ed6a07ded41528b5cbd
work_keys_str_mv	AT minwoolee changesineachretinallayerandellipsoidzonerecoveryafterfullthicknessmacularholesurgery AT taeyeonkim changesineachretinallayerandellipsoidzonerecoveryafterfullthicknessmacularholesurgery AT yongyeonsong changesineachretinallayerandellipsoidzonerecoveryafterfullthicknessmacularholesurgery AT seungkookbaek changesineachretinallayerandellipsoidzonerecoveryafterfullthicknessmacularholesurgery AT younghoonlee changesineachretinallayerandellipsoidzonerecoveryafterfullthicknessmacularholesurgery
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Changes in each retinal layer and ellipsoid zone recovery after full-thickness macular hole surgery

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