Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice

Innate immunity sensors are expressed by both tumour cells and tumour-associated myeloid cells. Here, the authors show that stimulation of the innate immunity response with pseudoviruses in a genetic mouse model of intestinal cancer triggers tumour regression via Caspase-1 activation.

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Autores principales:	Zhenyu Zhong, Yougang Zhai, Ping Bu, Shivanee Shah, Liang Qiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92ec82368ef3485b8daed75d8490090d
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spelling	oai:doaj.org-article:92ec82368ef3485b8daed75d8490090d2021-12-02T14:42:25ZPapilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice10.1038/ncomms150042041-1723https://doaj.org/article/92ec82368ef3485b8daed75d8490090d2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15004https://doaj.org/toc/2041-1723Innate immunity sensors are expressed by both tumour cells and tumour-associated myeloid cells. Here, the authors show that stimulation of the innate immunity response with pseudoviruses in a genetic mouse model of intestinal cancer triggers tumour regression via Caspase-1 activation.Zhenyu ZhongYougang ZhaiPing BuShivanee ShahLiang QiaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhenyu Zhong Yougang Zhai Ping Bu Shivanee Shah Liang Qiao Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice
description	Innate immunity sensors are expressed by both tumour cells and tumour-associated myeloid cells. Here, the authors show that stimulation of the innate immunity response with pseudoviruses in a genetic mouse model of intestinal cancer triggers tumour regression via Caspase-1 activation.
format	article
author	Zhenyu Zhong Yougang Zhai Ping Bu Shivanee Shah Liang Qiao
author_facet	Zhenyu Zhong Yougang Zhai Ping Bu Shivanee Shah Liang Qiao
author_sort	Zhenyu Zhong
title	Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice
title_short	Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice
title_full	Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice
title_fullStr	Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice
title_full_unstemmed	Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice
title_sort	papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of apcmin/+ mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/92ec82368ef3485b8daed75d8490090d
work_keys_str_mv	AT zhenyuzhong papillomapseudoviruseradicatesintestinaltumoursandtriplesthelifespanofapcminmice AT yougangzhai papillomapseudoviruseradicatesintestinaltumoursandtriplesthelifespanofapcminmice AT pingbu papillomapseudoviruseradicatesintestinaltumoursandtriplesthelifespanofapcminmice AT shivaneeshah papillomapseudoviruseradicatesintestinaltumoursandtriplesthelifespanofapcminmice AT liangqiao papillomapseudoviruseradicatesintestinaltumoursandtriplesthelifespanofapcminmice
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Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice

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