Ataxin-2-like is a regulator of stress granules and processing bodies.

Paralogs for several proteins implicated in neurodegenerative disorders have been identified and explored to further facilitate the identification of molecular mechanisms contributing to disease pathogenesis. For the disease-causing protein in spinocerebellar ataxia type 2, ataxin-2, a paralog of un...

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Autores principales:	Christian Kaehler, Jörg Isensee, Ute Nonhoff, Markus Terrey, Tim Hucho, Hans Lehrach, Sylvia Krobitsch
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92ed4a48c1e746ecbb9de878b93b2ebf
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spelling	oai:doaj.org-article:92ed4a48c1e746ecbb9de878b93b2ebf2021-11-18T08:07:25ZAtaxin-2-like is a regulator of stress granules and processing bodies.1932-620310.1371/journal.pone.0050134https://doaj.org/article/92ed4a48c1e746ecbb9de878b93b2ebf2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209657/?tool=EBIhttps://doaj.org/toc/1932-6203Paralogs for several proteins implicated in neurodegenerative disorders have been identified and explored to further facilitate the identification of molecular mechanisms contributing to disease pathogenesis. For the disease-causing protein in spinocerebellar ataxia type 2, ataxin-2, a paralog of unknown function, termed ataxin-2-like, has been described. We discovered that ataxin-2-like associates with known interaction partners of ataxin-2, the RNA helicase DDX6 and the poly(A)-binding protein, and with ataxin-2 itself. Furthermore, we found that ataxin-2-like is a component of stress granules. Interestingly, sole ataxin-2-like overexpression led to the induction of stress granules, while a reduction of stress granules was detected in case of a low ataxin-2-like level. Finally, we observed that overexpression of ataxin-2-like as well as its reduction has an impact on the presence of microscopically visible processing bodies. Thus, our results imply a functional overlap between ataxin-2-like and ataxin-2, and further indicate a role for ataxin-2-like in the regulation of stress granules and processing bodies.Christian KaehlerJörg IsenseeUte NonhoffMarkus TerreyTim HuchoHans LehrachSylvia KrobitschPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e50134 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian Kaehler Jörg Isensee Ute Nonhoff Markus Terrey Tim Hucho Hans Lehrach Sylvia Krobitsch Ataxin-2-like is a regulator of stress granules and processing bodies.
description	Paralogs for several proteins implicated in neurodegenerative disorders have been identified and explored to further facilitate the identification of molecular mechanisms contributing to disease pathogenesis. For the disease-causing protein in spinocerebellar ataxia type 2, ataxin-2, a paralog of unknown function, termed ataxin-2-like, has been described. We discovered that ataxin-2-like associates with known interaction partners of ataxin-2, the RNA helicase DDX6 and the poly(A)-binding protein, and with ataxin-2 itself. Furthermore, we found that ataxin-2-like is a component of stress granules. Interestingly, sole ataxin-2-like overexpression led to the induction of stress granules, while a reduction of stress granules was detected in case of a low ataxin-2-like level. Finally, we observed that overexpression of ataxin-2-like as well as its reduction has an impact on the presence of microscopically visible processing bodies. Thus, our results imply a functional overlap between ataxin-2-like and ataxin-2, and further indicate a role for ataxin-2-like in the regulation of stress granules and processing bodies.
format	article
author	Christian Kaehler Jörg Isensee Ute Nonhoff Markus Terrey Tim Hucho Hans Lehrach Sylvia Krobitsch
author_facet	Christian Kaehler Jörg Isensee Ute Nonhoff Markus Terrey Tim Hucho Hans Lehrach Sylvia Krobitsch
author_sort	Christian Kaehler
title	Ataxin-2-like is a regulator of stress granules and processing bodies.
title_short	Ataxin-2-like is a regulator of stress granules and processing bodies.
title_full	Ataxin-2-like is a regulator of stress granules and processing bodies.
title_fullStr	Ataxin-2-like is a regulator of stress granules and processing bodies.
title_full_unstemmed	Ataxin-2-like is a regulator of stress granules and processing bodies.
title_sort	ataxin-2-like is a regulator of stress granules and processing bodies.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/92ed4a48c1e746ecbb9de878b93b2ebf
work_keys_str_mv	AT christiankaehler ataxin2likeisaregulatorofstressgranulesandprocessingbodies AT jorgisensee ataxin2likeisaregulatorofstressgranulesandprocessingbodies AT utenonhoff ataxin2likeisaregulatorofstressgranulesandprocessingbodies AT markusterrey ataxin2likeisaregulatorofstressgranulesandprocessingbodies AT timhucho ataxin2likeisaregulatorofstressgranulesandprocessingbodies AT hanslehrach ataxin2likeisaregulatorofstressgranulesandprocessingbodies AT sylviakrobitsch ataxin2likeisaregulatorofstressgranulesandprocessingbodies
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Ataxin-2-like is a regulator of stress granules and processing bodies.

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