Potential zoonotic pathogens hosted by endangered bonobos

Abstract Few publications, often limited to one specific pathogen, have studied bonobos (Pan paniscus), our closest living relatives, as possible reservoirs of certain human infectious agents. Here, 91 stool samples from semicaptive bonobos and bonobos reintroduced in the wild, in the Democratic Rep...

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Autores principales:	Hacène Medkour, Sergei Castaneda, Inestin Amona, Florence Fenollar, Claudine André, Raphaël Belais, Paulin Mungongo, Jean-Jacques Muyembé-Tamfum, Anthony Levasseur, Didier Raoult, Bernard Davoust, Oleg Mediannikov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92edf6d7781f451fabf7a3bb7798b651
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spelling	oai:doaj.org-article:92edf6d7781f451fabf7a3bb7798b6512021-12-02T11:39:27ZPotential zoonotic pathogens hosted by endangered bonobos10.1038/s41598-021-85849-42045-2322https://doaj.org/article/92edf6d7781f451fabf7a3bb7798b6512021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85849-4https://doaj.org/toc/2045-2322Abstract Few publications, often limited to one specific pathogen, have studied bonobos (Pan paniscus), our closest living relatives, as possible reservoirs of certain human infectious agents. Here, 91 stool samples from semicaptive bonobos and bonobos reintroduced in the wild, in the Democratic Republic of the Congo, were screened for different infectious agents: viruses, bacteria and parasites. We showed the presence of potentially zoonotic viral, bacterial or parasitic agents in stool samples, sometimes coinfecting the same individuals. A high prevalence of Human mastadenoviruses (HAdV-C, HAdV-B, HAdV-E) was observed. Encephalomyocarditis viruses were identified in semicaptive bonobos, although identified genotypes were different from those identified in the previous fatal myocarditis epidemic at the same site in 2009. Non-pallidum Treponema spp. including symbiotic T. succinifaciens, T. berlinense and several potential new species with unknown pathogenicity were identified. We detected DNA of non-tuberculosis Mycobacterium spp., Acinetobacter spp., Salmonella spp. as well as pathogenic Leptospira interrogans. Zoonotic parasites such as Taenia solium and Strongyloides stercoralis were predominantly present in wild bonobos, while Giardia lamblia was found only in bonobos in contact with humans, suggesting a possible exchange. One third of bonobos carried Oesophagostomum spp., particularly zoonotic O. stephanostomum and O. bifurcum-like species, as well as other uncharacterized Nematoda. Trypanosoma theileri has been identified in semicaptive bonobos. Pathogens typically known to be transmitted sexually were not identified. We present here the results of a reasonably-sized screening study detecting DNA/RNA sequence evidence of potentially pathogenic viruses and microorganisms in bonobo based on a noninvasive sampling method (feces) and focused PCR diagnostics.Hacène MedkourSergei CastanedaInestin AmonaFlorence FenollarClaudine AndréRaphaël BelaisPaulin MungongoJean-Jacques Muyembé-TamfumAnthony LevasseurDidier RaoultBernard DavoustOleg MediannikovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hacène Medkour Sergei Castaneda Inestin Amona Florence Fenollar Claudine André Raphaël Belais Paulin Mungongo Jean-Jacques Muyembé-Tamfum Anthony Levasseur Didier Raoult Bernard Davoust Oleg Mediannikov Potential zoonotic pathogens hosted by endangered bonobos
description	Abstract Few publications, often limited to one specific pathogen, have studied bonobos (Pan paniscus), our closest living relatives, as possible reservoirs of certain human infectious agents. Here, 91 stool samples from semicaptive bonobos and bonobos reintroduced in the wild, in the Democratic Republic of the Congo, were screened for different infectious agents: viruses, bacteria and parasites. We showed the presence of potentially zoonotic viral, bacterial or parasitic agents in stool samples, sometimes coinfecting the same individuals. A high prevalence of Human mastadenoviruses (HAdV-C, HAdV-B, HAdV-E) was observed. Encephalomyocarditis viruses were identified in semicaptive bonobos, although identified genotypes were different from those identified in the previous fatal myocarditis epidemic at the same site in 2009. Non-pallidum Treponema spp. including symbiotic T. succinifaciens, T. berlinense and several potential new species with unknown pathogenicity were identified. We detected DNA of non-tuberculosis Mycobacterium spp., Acinetobacter spp., Salmonella spp. as well as pathogenic Leptospira interrogans. Zoonotic parasites such as Taenia solium and Strongyloides stercoralis were predominantly present in wild bonobos, while Giardia lamblia was found only in bonobos in contact with humans, suggesting a possible exchange. One third of bonobos carried Oesophagostomum spp., particularly zoonotic O. stephanostomum and O. bifurcum-like species, as well as other uncharacterized Nematoda. Trypanosoma theileri has been identified in semicaptive bonobos. Pathogens typically known to be transmitted sexually were not identified. We present here the results of a reasonably-sized screening study detecting DNA/RNA sequence evidence of potentially pathogenic viruses and microorganisms in bonobo based on a noninvasive sampling method (feces) and focused PCR diagnostics.
format	article
author	Hacène Medkour Sergei Castaneda Inestin Amona Florence Fenollar Claudine André Raphaël Belais Paulin Mungongo Jean-Jacques Muyembé-Tamfum Anthony Levasseur Didier Raoult Bernard Davoust Oleg Mediannikov
author_facet	Hacène Medkour Sergei Castaneda Inestin Amona Florence Fenollar Claudine André Raphaël Belais Paulin Mungongo Jean-Jacques Muyembé-Tamfum Anthony Levasseur Didier Raoult Bernard Davoust Oleg Mediannikov
author_sort	Hacène Medkour
title	Potential zoonotic pathogens hosted by endangered bonobos
title_short	Potential zoonotic pathogens hosted by endangered bonobos
title_full	Potential zoonotic pathogens hosted by endangered bonobos
title_fullStr	Potential zoonotic pathogens hosted by endangered bonobos
title_full_unstemmed	Potential zoonotic pathogens hosted by endangered bonobos
title_sort	potential zoonotic pathogens hosted by endangered bonobos
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/92edf6d7781f451fabf7a3bb7798b651
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Potential zoonotic pathogens hosted by endangered bonobos

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