The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

Human Long INterspersed Element class 1 (LINE-1) elements are expressed and mobilized in many types of cancer, contributing to malignancy. Here the authors show that the tumor suppressor microRNA let-7 targets the LINE-1 mRNA and reduces LINE-1 mobilization.

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Autores principales:	Pablo Tristán-Ramos, Alejandro Rubio-Roldan, Guillermo Peris, Laura Sánchez, Suyapa Amador-Cubero, Sebastien Viollet, Gael Cristofari, Sara R. Heras
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92f12109ce524c348a62859af39c4dc9
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spelling	oai:doaj.org-article:92f12109ce524c348a62859af39c4dc92021-12-02T17:32:58ZThe tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition10.1038/s41467-020-19430-42041-1723https://doaj.org/article/92f12109ce524c348a62859af39c4dc92020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19430-4https://doaj.org/toc/2041-1723Human Long INterspersed Element class 1 (LINE-1) elements are expressed and mobilized in many types of cancer, contributing to malignancy. Here the authors show that the tumor suppressor microRNA let-7 targets the LINE-1 mRNA and reduces LINE-1 mobilization.Pablo Tristán-RamosAlejandro Rubio-RoldanGuillermo PerisLaura SánchezSuyapa Amador-CuberoSebastien ViolletGael CristofariSara R. HerasNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pablo Tristán-Ramos Alejandro Rubio-Roldan Guillermo Peris Laura Sánchez Suyapa Amador-Cubero Sebastien Viollet Gael Cristofari Sara R. Heras The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
description	Human Long INterspersed Element class 1 (LINE-1) elements are expressed and mobilized in many types of cancer, contributing to malignancy. Here the authors show that the tumor suppressor microRNA let-7 targets the LINE-1 mRNA and reduces LINE-1 mobilization.
format	article
author	Pablo Tristán-Ramos Alejandro Rubio-Roldan Guillermo Peris Laura Sánchez Suyapa Amador-Cubero Sebastien Viollet Gael Cristofari Sara R. Heras
author_facet	Pablo Tristán-Ramos Alejandro Rubio-Roldan Guillermo Peris Laura Sánchez Suyapa Amador-Cubero Sebastien Viollet Gael Cristofari Sara R. Heras
author_sort	Pablo Tristán-Ramos
title	The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
title_short	The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
title_full	The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
title_fullStr	The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
title_full_unstemmed	The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
title_sort	tumor suppressor microrna let-7 inhibits human line-1 retrotransposition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/92f12109ce524c348a62859af39c4dc9
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The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

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