Identification of close relatives in the HUGO Pan-Asian SNP database.

The HUGO Pan-Asian SNP Consortium has recently released a genome-wide dataset, which consists of 1,719 DNA samples collected from 71 Asian populations. For studies of human population genetics such as genetic structure and migration history, this provided the most comprehensive large-scale survey of...

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Autores principales:	Xiong Yang, Shuhua Xu, HUGO Pan-Asian SNP Consortium, Indian Genome Variation Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92f2b7f1cbc14a4cac0ca2f9733f0838
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spelling	oai:doaj.org-article:92f2b7f1cbc14a4cac0ca2f9733f08382021-11-18T07:31:16ZIdentification of close relatives in the HUGO Pan-Asian SNP database.1932-620310.1371/journal.pone.0029502https://doaj.org/article/92f2b7f1cbc14a4cac0ca2f9733f08382011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22242128/?tool=EBIhttps://doaj.org/toc/1932-6203The HUGO Pan-Asian SNP Consortium has recently released a genome-wide dataset, which consists of 1,719 DNA samples collected from 71 Asian populations. For studies of human population genetics such as genetic structure and migration history, this provided the most comprehensive large-scale survey of genetic variation to date in East and Southeast Asia. However, although considered in the analysis, close relatives were not clearly reported in the original paper. Here we performed a systematic analysis of genetic relationships among individuals from the Pan-Asian SNP (PASNP) database and identified 3 pairs of monozygotic twins or duplicate samples, 100 pairs of first-degree and 161 second-degree of relationships. Three standardized subsets with different levels of unrelated individuals were suggested here for future applications of the samples in most types of population-genetics studies (denoted by PASNP1716, PASNP1640 and PASNP1583 respectively) based on the relationships inferred in this study. In addition, we provided gender information for PASNP samples, which were not included in the original dataset, based on analysis of X chromosome data.Xiong YangShuhua XuHUGO Pan-Asian SNP ConsortiumIndian Genome Variation ConsortiumPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e29502 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiong Yang Shuhua Xu HUGO Pan-Asian SNP Consortium Indian Genome Variation Consortium Identification of close relatives in the HUGO Pan-Asian SNP database.
description	The HUGO Pan-Asian SNP Consortium has recently released a genome-wide dataset, which consists of 1,719 DNA samples collected from 71 Asian populations. For studies of human population genetics such as genetic structure and migration history, this provided the most comprehensive large-scale survey of genetic variation to date in East and Southeast Asia. However, although considered in the analysis, close relatives were not clearly reported in the original paper. Here we performed a systematic analysis of genetic relationships among individuals from the Pan-Asian SNP (PASNP) database and identified 3 pairs of monozygotic twins or duplicate samples, 100 pairs of first-degree and 161 second-degree of relationships. Three standardized subsets with different levels of unrelated individuals were suggested here for future applications of the samples in most types of population-genetics studies (denoted by PASNP1716, PASNP1640 and PASNP1583 respectively) based on the relationships inferred in this study. In addition, we provided gender information for PASNP samples, which were not included in the original dataset, based on analysis of X chromosome data.
format	article
author	Xiong Yang Shuhua Xu HUGO Pan-Asian SNP Consortium Indian Genome Variation Consortium
author_facet	Xiong Yang Shuhua Xu HUGO Pan-Asian SNP Consortium Indian Genome Variation Consortium
author_sort	Xiong Yang
title	Identification of close relatives in the HUGO Pan-Asian SNP database.
title_short	Identification of close relatives in the HUGO Pan-Asian SNP database.
title_full	Identification of close relatives in the HUGO Pan-Asian SNP database.
title_fullStr	Identification of close relatives in the HUGO Pan-Asian SNP database.
title_full_unstemmed	Identification of close relatives in the HUGO Pan-Asian SNP database.
title_sort	identification of close relatives in the hugo pan-asian snp database.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/92f2b7f1cbc14a4cac0ca2f9733f0838
work_keys_str_mv	AT xiongyang identificationofcloserelativesinthehugopanasiansnpdatabase AT shuhuaxu identificationofcloserelativesinthehugopanasiansnpdatabase AT hugopanasiansnpconsortium identificationofcloserelativesinthehugopanasiansnpdatabase AT indiangenomevariationconsortium identificationofcloserelativesinthehugopanasiansnpdatabase
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Identification of close relatives in the HUGO Pan-Asian SNP database.

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