GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation

GDF11 is related to myostatin yet has no known role in postnatal bone turnover. Here the authors show that recombinant GDF11 injection causes bone loss and impairs healing by driving osteoclastogenesis while inhibiting osteoblast differentiation, plus they show that anti-GDF11 Ab can inhibit bone lo...

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Autores principales:	Weiqing Liu, Liyan Zhou, Chenchen Zhou, Shiwen Zhang, Junjun Jing, Liang Xie, Ningyuan Sun, Xiaobo Duan, Wei Jing, Xing Liang, Hu Zhao, Ling Ye, Qianming Chen, Quan Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92f4ec1716274c7a8ccce65d4bcc5e2d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:92f4ec1716274c7a8ccce65d4bcc5e2d2021-12-02T14:39:51ZGDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation10.1038/ncomms127942041-1723https://doaj.org/article/92f4ec1716274c7a8ccce65d4bcc5e2d2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12794https://doaj.org/toc/2041-1723GDF11 is related to myostatin yet has no known role in postnatal bone turnover. Here the authors show that recombinant GDF11 injection causes bone loss and impairs healing by driving osteoclastogenesis while inhibiting osteoblast differentiation, plus they show that anti-GDF11 Ab can inhibit bone loss in ovariectomy and ageing mouse models.Weiqing LiuLiyan ZhouChenchen ZhouShiwen ZhangJunjun JingLiang XieNingyuan SunXiaobo DuanWei JingXing LiangHu ZhaoLing YeQianming ChenQuan YuanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weiqing Liu Liyan Zhou Chenchen Zhou Shiwen Zhang Junjun Jing Liang Xie Ningyuan Sun Xiaobo Duan Wei Jing Xing Liang Hu Zhao Ling Ye Qianming Chen Quan Yuan GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation
description	GDF11 is related to myostatin yet has no known role in postnatal bone turnover. Here the authors show that recombinant GDF11 injection causes bone loss and impairs healing by driving osteoclastogenesis while inhibiting osteoblast differentiation, plus they show that anti-GDF11 Ab can inhibit bone loss in ovariectomy and ageing mouse models.
format	article
author	Weiqing Liu Liyan Zhou Chenchen Zhou Shiwen Zhang Junjun Jing Liang Xie Ningyuan Sun Xiaobo Duan Wei Jing Xing Liang Hu Zhao Ling Ye Qianming Chen Quan Yuan
author_facet	Weiqing Liu Liyan Zhou Chenchen Zhou Shiwen Zhang Junjun Jing Liang Xie Ningyuan Sun Xiaobo Duan Wei Jing Xing Liang Hu Zhao Ling Ye Qianming Chen Quan Yuan
author_sort	Weiqing Liu
title	GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation
title_short	GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation
title_full	GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation
title_fullStr	GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation
title_full_unstemmed	GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation
title_sort	gdf11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/92f4ec1716274c7a8ccce65d4bcc5e2d
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GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation

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