Case Report: Propranolol Therapy for Infantile Tremor Syndrome in a Child With Vitamin B12 Deficiency

Vitamin B12 deficiency in childhood presents with a wide variety of symptoms including anemia, failure to thrive and developmental delays. It is a diagnostic consideration in children who are exclusively breastfed or have minimal solid intake, especially if their mother is vegetarian or has underlyi...

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Autores principales:	Amélie Cyr, Ryan Frehlick, David Stammers, Megan Crone
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neurology hematology vitamin B12 deficiency infantile tremor syndrome propranolol Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/92f6322ed2ad43f888c9811b6768a238
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spelling	oai:doaj.org-article:92f6322ed2ad43f888c9811b6768a2382021-11-30T18:47:16ZCase Report: Propranolol Therapy for Infantile Tremor Syndrome in a Child With Vitamin B12 Deficiency2296-236010.3389/fped.2021.774747https://doaj.org/article/92f6322ed2ad43f888c9811b6768a2382021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.774747/fullhttps://doaj.org/toc/2296-2360Vitamin B12 deficiency in childhood presents with a wide variety of symptoms including anemia, failure to thrive and developmental delays. It is a diagnostic consideration in children who are exclusively breastfed or have minimal solid intake, especially if their mother is vegetarian or has underlying vitamin B12 deficiency. Infantile tremor syndrome (ITS) has been associated with vitamin B12 deficiency. ITS presents with neurological symptoms such as developmental delays and tremors. The tremors seen in ITS can be profound and interfere with daily functioning. Different therapies have been tried for those tremors without much evidence or information regarding their efficacy and dosing regimens. We present the case of a 13-month-old girl with vitamin B12 deficiency who developed ITS with significant tremors after initiation of vitamin B12 therapy. She was treated with propranolol which resulted in significant improvement in her tremors. This case highlights the efficacy and safety of propranolol for the treatment of ITS in the context of vitamin B12 deficiency.Amélie CyrRyan FrehlickDavid StammersMegan CroneFrontiers Media S.A.articleneurologyhematologyvitamin B12 deficiencyinfantile tremor syndromepropranololPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurology hematology vitamin B12 deficiency infantile tremor syndrome propranolol Pediatrics RJ1-570
spellingShingle	neurology hematology vitamin B12 deficiency infantile tremor syndrome propranolol Pediatrics RJ1-570 Amélie Cyr Ryan Frehlick David Stammers Megan Crone Case Report: Propranolol Therapy for Infantile Tremor Syndrome in a Child With Vitamin B12 Deficiency
description	Vitamin B12 deficiency in childhood presents with a wide variety of symptoms including anemia, failure to thrive and developmental delays. It is a diagnostic consideration in children who are exclusively breastfed or have minimal solid intake, especially if their mother is vegetarian or has underlying vitamin B12 deficiency. Infantile tremor syndrome (ITS) has been associated with vitamin B12 deficiency. ITS presents with neurological symptoms such as developmental delays and tremors. The tremors seen in ITS can be profound and interfere with daily functioning. Different therapies have been tried for those tremors without much evidence or information regarding their efficacy and dosing regimens. We present the case of a 13-month-old girl with vitamin B12 deficiency who developed ITS with significant tremors after initiation of vitamin B12 therapy. She was treated with propranolol which resulted in significant improvement in her tremors. This case highlights the efficacy and safety of propranolol for the treatment of ITS in the context of vitamin B12 deficiency.
format	article
author	Amélie Cyr Ryan Frehlick David Stammers Megan Crone
author_facet	Amélie Cyr Ryan Frehlick David Stammers Megan Crone
author_sort	Amélie Cyr
title	Case Report: Propranolol Therapy for Infantile Tremor Syndrome in a Child With Vitamin B12 Deficiency
title_short	Case Report: Propranolol Therapy for Infantile Tremor Syndrome in a Child With Vitamin B12 Deficiency
title_full	Case Report: Propranolol Therapy for Infantile Tremor Syndrome in a Child With Vitamin B12 Deficiency
title_fullStr	Case Report: Propranolol Therapy for Infantile Tremor Syndrome in a Child With Vitamin B12 Deficiency
title_full_unstemmed	Case Report: Propranolol Therapy for Infantile Tremor Syndrome in a Child With Vitamin B12 Deficiency
title_sort	case report: propranolol therapy for infantile tremor syndrome in a child with vitamin b12 deficiency
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/92f6322ed2ad43f888c9811b6768a238
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Case Report: Propranolol Therapy for Infantile Tremor Syndrome in a Child With Vitamin B12 Deficiency

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