Quantification of the Rupture Potential of Patient-Specific Intracranial Aneurysms under Contact Constraints

Intracranial aneurysms (IAs) are localized enlargements of cerebral blood vessels that cause substantial rates of mortality and morbidity in humans. The rupture possibility of these aneurysms is a critical medical challenge for physicians during treatment planning. This treatment planning while asse...

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Autores principales:	Manjurul Alam, Fernando Mut, Juan R. Cebral, Padmanabhan Seshaiyer
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	intracranial aneurysms hyper-elastic membrane contact constraints rupture potential effective wall stress Technology T Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/92f8dbaa56c1418abd5c4076af340d48
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spelling	oai:doaj.org-article:92f8dbaa56c1418abd5c4076af340d482021-11-25T16:46:20ZQuantification of the Rupture Potential of Patient-Specific Intracranial Aneurysms under Contact Constraints10.3390/bioengineering81101492306-5354https://doaj.org/article/92f8dbaa56c1418abd5c4076af340d482021-10-01T00:00:00Zhttps://www.mdpi.com/2306-5354/8/11/149https://doaj.org/toc/2306-5354Intracranial aneurysms (IAs) are localized enlargements of cerebral blood vessels that cause substantial rates of mortality and morbidity in humans. The rupture possibility of these aneurysms is a critical medical challenge for physicians during treatment planning. This treatment planning while assessing the rupture potential of aneurysms becomes more complicated when they are constrained by an adjacent structure such as optic nerve tissues or bones, which is not widely studied yet. In this work, we considered and studied a constitutive model to investigate the bio-mechanical response of image-based patient-specific IA data using cardiovascular structural mechanics equations. We performed biomechanical modeling and simulations of four different patient-specific aneurysms’ data (three middle cerebral arteries and one internal carotid artery) to assess the rupture potential of those aneurysms under a plane contact constraint. Our results suggest that aneurysms with plane contact constraints produce less or almost similar maximum wall effective stress compared to aneurysms with no contact constraints. In our research findings, we observed that a plane contact constraint on top of an internal carotid artery might work as a protective wall due to the 16.6% reduction in maximum wall effective stress than that for the case where there is no contact on top of the aneurysm.Manjurul AlamFernando MutJuan R. CebralPadmanabhan SeshaiyerMDPI AGarticleintracranial aneurysmshyper-elastic membranecontact constraintsrupture potentialeffective wall stressTechnologyTBiology (General)QH301-705.5ENBioengineering, Vol 8, Iss 149, p 149 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intracranial aneurysms hyper-elastic membrane contact constraints rupture potential effective wall stress Technology T Biology (General) QH301-705.5
spellingShingle	intracranial aneurysms hyper-elastic membrane contact constraints rupture potential effective wall stress Technology T Biology (General) QH301-705.5 Manjurul Alam Fernando Mut Juan R. Cebral Padmanabhan Seshaiyer Quantification of the Rupture Potential of Patient-Specific Intracranial Aneurysms under Contact Constraints
description	Intracranial aneurysms (IAs) are localized enlargements of cerebral blood vessels that cause substantial rates of mortality and morbidity in humans. The rupture possibility of these aneurysms is a critical medical challenge for physicians during treatment planning. This treatment planning while assessing the rupture potential of aneurysms becomes more complicated when they are constrained by an adjacent structure such as optic nerve tissues or bones, which is not widely studied yet. In this work, we considered and studied a constitutive model to investigate the bio-mechanical response of image-based patient-specific IA data using cardiovascular structural mechanics equations. We performed biomechanical modeling and simulations of four different patient-specific aneurysms’ data (three middle cerebral arteries and one internal carotid artery) to assess the rupture potential of those aneurysms under a plane contact constraint. Our results suggest that aneurysms with plane contact constraints produce less or almost similar maximum wall effective stress compared to aneurysms with no contact constraints. In our research findings, we observed that a plane contact constraint on top of an internal carotid artery might work as a protective wall due to the 16.6% reduction in maximum wall effective stress than that for the case where there is no contact on top of the aneurysm.
format	article
author	Manjurul Alam Fernando Mut Juan R. Cebral Padmanabhan Seshaiyer
author_facet	Manjurul Alam Fernando Mut Juan R. Cebral Padmanabhan Seshaiyer
author_sort	Manjurul Alam
title	Quantification of the Rupture Potential of Patient-Specific Intracranial Aneurysms under Contact Constraints
title_short	Quantification of the Rupture Potential of Patient-Specific Intracranial Aneurysms under Contact Constraints
title_full	Quantification of the Rupture Potential of Patient-Specific Intracranial Aneurysms under Contact Constraints
title_fullStr	Quantification of the Rupture Potential of Patient-Specific Intracranial Aneurysms under Contact Constraints
title_full_unstemmed	Quantification of the Rupture Potential of Patient-Specific Intracranial Aneurysms under Contact Constraints
title_sort	quantification of the rupture potential of patient-specific intracranial aneurysms under contact constraints
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/92f8dbaa56c1418abd5c4076af340d48
work_keys_str_mv	AT manjurulalam quantificationoftherupturepotentialofpatientspecificintracranialaneurysmsundercontactconstraints AT fernandomut quantificationoftherupturepotentialofpatientspecificintracranialaneurysmsundercontactconstraints AT juanrcebral quantificationoftherupturepotentialofpatientspecificintracranialaneurysmsundercontactconstraints AT padmanabhanseshaiyer quantificationoftherupturepotentialofpatientspecificintracranialaneurysmsundercontactconstraints
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Quantification of the Rupture Potential of Patient-Specific Intracranial Aneurysms under Contact Constraints

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