Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review

Abstract Stem cell-based regenerative therapy has opened an avenue for functional recovery of patients with spinal cord injury (SCI). Regenerative rehabilitation is attracting wide attention owing to its synergistic effects, feasibility, non-invasiveness, and diverse and systemic properties. In this...

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Autores principales:	Syoichi Tashiro, Osahiko Tsuji, Munehisa Shinozaki, Takahiro Shibata, Takashi Yoshida, Yohei Tomioka, Kei Unai, Takahiro Kondo, Go Itakura, Yoshiomi Kobayashi, Akimasa Yasuda, Satoshi Nori, Kanehiro Fujiyoshi, Narihito Nagoshi, Michiyuki Kawakami, Osamu Uemura, Shin Yamada, Tetsuya Tsuji, Hideyuki Okano, Masaya Nakamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/92f922d3d7c849a2b38aabfe64a89750
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spelling	oai:doaj.org-article:92f922d3d7c849a2b38aabfe64a897502021-11-28T12:38:29ZCurrent progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review10.1038/s41536-021-00191-72057-3995https://doaj.org/article/92f922d3d7c849a2b38aabfe64a897502021-11-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00191-7https://doaj.org/toc/2057-3995Abstract Stem cell-based regenerative therapy has opened an avenue for functional recovery of patients with spinal cord injury (SCI). Regenerative rehabilitation is attracting wide attention owing to its synergistic effects, feasibility, non-invasiveness, and diverse and systemic properties. In this review article, we summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of SCI. Although conventional rehabilitative methods have commonly been implemented alone, especially in studies of acute-to-subacute SCI, the combinatorial effects of intensive and advanced methods, including various neurorehabilitative approaches, have also been reported. Separating the concept of combined rehabilitation from regenerative rehabilitation, we suggest that the main roles of regenerative rehabilitation can be categorized as conditioning/reconditioning, functional training, and physical exercise, all of which are indispensable for enhancing functional recovery achieved using stem cell therapies.Syoichi TashiroOsahiko TsujiMunehisa ShinozakiTakahiro ShibataTakashi YoshidaYohei TomiokaKei UnaiTakahiro KondoGo ItakuraYoshiomi KobayashiAkimasa YasudaSatoshi NoriKanehiro FujiyoshiNarihito NagoshiMichiyuki KawakamiOsamu UemuraShin YamadaTetsuya TsujiHideyuki OkanoMasaya NakamuraNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Syoichi Tashiro Osahiko Tsuji Munehisa Shinozaki Takahiro Shibata Takashi Yoshida Yohei Tomioka Kei Unai Takahiro Kondo Go Itakura Yoshiomi Kobayashi Akimasa Yasuda Satoshi Nori Kanehiro Fujiyoshi Narihito Nagoshi Michiyuki Kawakami Osamu Uemura Shin Yamada Tetsuya Tsuji Hideyuki Okano Masaya Nakamura Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review
description	Abstract Stem cell-based regenerative therapy has opened an avenue for functional recovery of patients with spinal cord injury (SCI). Regenerative rehabilitation is attracting wide attention owing to its synergistic effects, feasibility, non-invasiveness, and diverse and systemic properties. In this review article, we summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of SCI. Although conventional rehabilitative methods have commonly been implemented alone, especially in studies of acute-to-subacute SCI, the combinatorial effects of intensive and advanced methods, including various neurorehabilitative approaches, have also been reported. Separating the concept of combined rehabilitation from regenerative rehabilitation, we suggest that the main roles of regenerative rehabilitation can be categorized as conditioning/reconditioning, functional training, and physical exercise, all of which are indispensable for enhancing functional recovery achieved using stem cell therapies.
format	article
author	Syoichi Tashiro Osahiko Tsuji Munehisa Shinozaki Takahiro Shibata Takashi Yoshida Yohei Tomioka Kei Unai Takahiro Kondo Go Itakura Yoshiomi Kobayashi Akimasa Yasuda Satoshi Nori Kanehiro Fujiyoshi Narihito Nagoshi Michiyuki Kawakami Osamu Uemura Shin Yamada Tetsuya Tsuji Hideyuki Okano Masaya Nakamura
author_facet	Syoichi Tashiro Osahiko Tsuji Munehisa Shinozaki Takahiro Shibata Takashi Yoshida Yohei Tomioka Kei Unai Takahiro Kondo Go Itakura Yoshiomi Kobayashi Akimasa Yasuda Satoshi Nori Kanehiro Fujiyoshi Narihito Nagoshi Michiyuki Kawakami Osamu Uemura Shin Yamada Tetsuya Tsuji Hideyuki Okano Masaya Nakamura
author_sort	Syoichi Tashiro
title	Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review
title_short	Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review
title_full	Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review
title_fullStr	Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review
title_full_unstemmed	Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review
title_sort	current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/92f922d3d7c849a2b38aabfe64a89750
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Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review

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