A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression
Retinoblastoma is the most frequent intraocular paediatric malignancy whose molecular basis remains poorly understood. Here, the authors perform multi-omic analysis and identify two subtypes; one in a cone differentiated state and one more aggressive showing cone dedifferentiation and expressing neu...
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Nature Portfolio
2021
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oai:doaj.org-article:92fda6743ce64715a5b5d4c807ca5ced2021-12-02T15:15:05ZA high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression10.1038/s41467-021-25792-02041-1723https://doaj.org/article/92fda6743ce64715a5b5d4c807ca5ced2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25792-0https://doaj.org/toc/2041-1723Retinoblastoma is the most frequent intraocular paediatric malignancy whose molecular basis remains poorly understood. Here, the authors perform multi-omic analysis and identify two subtypes; one in a cone differentiated state and one more aggressive showing cone dedifferentiation and expressing neuronal markers.Jing LiuDaniela OttavianiMeriem SeftaCéline DesbroussesElodie ChapeaublancRosario AscheroNanor SirabFabiana LubienieckiGabriela LamasLaurie TononCatherine DehainaultClément HuaPaul FréneauxSacha ReichmanNarjesse KarboulAnne BitonLiliana Mirabal-OrtegaMagalie LarcherCéline BrulardSandrine ArrufatAndré NicolasNabila ElarouciTatiana PopovaFariba NématiDidier DecaudinDavid GentienSylvain BaulandeOdette MarianiFlorent DufourSylvain GuibertCéline VallotLivia Lumbroso-Le RouicAlexandre MatetLaurence DesjardinsGuillem Pascual-PastoMariona SuñolJaume Catala-MoraGenoveva Correa LlanoJérôme CouturierEmmanuel BarillotPaula SchaiquevichMarion Gauthier-VillarsDominique Stoppa-LyonnetLisa GolmardClaude HoudayerHervé BrisseIsabelle Bernard-PierrotEric LetouzéAlain ViariSimon SauleXavier Sastre-GarauFrançois DozAngel M. CarcabosoNathalie CassouxCelio PouponnotOlivier GoureauGuillermo ChantadaAurélien de ReynièsIsabelle AertsFrançois RadvanyiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021) |
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DOAJ |
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EN |
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Science Q |
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Science Q Jing Liu Daniela Ottaviani Meriem Sefta Céline Desbrousses Elodie Chapeaublanc Rosario Aschero Nanor Sirab Fabiana Lubieniecki Gabriela Lamas Laurie Tonon Catherine Dehainault Clément Hua Paul Fréneaux Sacha Reichman Narjesse Karboul Anne Biton Liliana Mirabal-Ortega Magalie Larcher Céline Brulard Sandrine Arrufat André Nicolas Nabila Elarouci Tatiana Popova Fariba Némati Didier Decaudin David Gentien Sylvain Baulande Odette Mariani Florent Dufour Sylvain Guibert Céline Vallot Livia Lumbroso-Le Rouic Alexandre Matet Laurence Desjardins Guillem Pascual-Pasto Mariona Suñol Jaume Catala-Mora Genoveva Correa Llano Jérôme Couturier Emmanuel Barillot Paula Schaiquevich Marion Gauthier-Villars Dominique Stoppa-Lyonnet Lisa Golmard Claude Houdayer Hervé Brisse Isabelle Bernard-Pierrot Eric Letouzé Alain Viari Simon Saule Xavier Sastre-Garau François Doz Angel M. Carcaboso Nathalie Cassoux Celio Pouponnot Olivier Goureau Guillermo Chantada Aurélien de Reyniès Isabelle Aerts François Radvanyi A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression |
| description |
Retinoblastoma is the most frequent intraocular paediatric malignancy whose molecular basis remains poorly understood. Here, the authors perform multi-omic analysis and identify two subtypes; one in a cone differentiated state and one more aggressive showing cone dedifferentiation and expressing neuronal markers. |
| format |
article |
| author |
Jing Liu Daniela Ottaviani Meriem Sefta Céline Desbrousses Elodie Chapeaublanc Rosario Aschero Nanor Sirab Fabiana Lubieniecki Gabriela Lamas Laurie Tonon Catherine Dehainault Clément Hua Paul Fréneaux Sacha Reichman Narjesse Karboul Anne Biton Liliana Mirabal-Ortega Magalie Larcher Céline Brulard Sandrine Arrufat André Nicolas Nabila Elarouci Tatiana Popova Fariba Némati Didier Decaudin David Gentien Sylvain Baulande Odette Mariani Florent Dufour Sylvain Guibert Céline Vallot Livia Lumbroso-Le Rouic Alexandre Matet Laurence Desjardins Guillem Pascual-Pasto Mariona Suñol Jaume Catala-Mora Genoveva Correa Llano Jérôme Couturier Emmanuel Barillot Paula Schaiquevich Marion Gauthier-Villars Dominique Stoppa-Lyonnet Lisa Golmard Claude Houdayer Hervé Brisse Isabelle Bernard-Pierrot Eric Letouzé Alain Viari Simon Saule Xavier Sastre-Garau François Doz Angel M. Carcaboso Nathalie Cassoux Celio Pouponnot Olivier Goureau Guillermo Chantada Aurélien de Reyniès Isabelle Aerts François Radvanyi |
| author_facet |
Jing Liu Daniela Ottaviani Meriem Sefta Céline Desbrousses Elodie Chapeaublanc Rosario Aschero Nanor Sirab Fabiana Lubieniecki Gabriela Lamas Laurie Tonon Catherine Dehainault Clément Hua Paul Fréneaux Sacha Reichman Narjesse Karboul Anne Biton Liliana Mirabal-Ortega Magalie Larcher Céline Brulard Sandrine Arrufat André Nicolas Nabila Elarouci Tatiana Popova Fariba Némati Didier Decaudin David Gentien Sylvain Baulande Odette Mariani Florent Dufour Sylvain Guibert Céline Vallot Livia Lumbroso-Le Rouic Alexandre Matet Laurence Desjardins Guillem Pascual-Pasto Mariona Suñol Jaume Catala-Mora Genoveva Correa Llano Jérôme Couturier Emmanuel Barillot Paula Schaiquevich Marion Gauthier-Villars Dominique Stoppa-Lyonnet Lisa Golmard Claude Houdayer Hervé Brisse Isabelle Bernard-Pierrot Eric Letouzé Alain Viari Simon Saule Xavier Sastre-Garau François Doz Angel M. Carcaboso Nathalie Cassoux Celio Pouponnot Olivier Goureau Guillermo Chantada Aurélien de Reyniès Isabelle Aerts François Radvanyi |
| author_sort |
Jing Liu |
| title |
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression |
| title_short |
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression |
| title_full |
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression |
| title_fullStr |
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression |
| title_full_unstemmed |
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression |
| title_sort |
high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/92fda6743ce64715a5b5d4c807ca5ced |
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