Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation

TET mediated RNA-hydroxymethylation (5hmC) has been detected in mammals, but its physiological role remains unclear. Here the authors map 5hmC during embryonic stem cell (ESC) differentiation and find that Tet-mediated RNA hydroxymethylation reduces the stability of crucial pluripotency related tran...

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Autores principales:	Jie Lan, Nicholas Rajan, Martin Bizet, Audrey Penning, Nitesh K. Singh, Diana Guallar, Emilie Calonne, Andrea Li Greci, Elise Bonvin, Rachel Deplus, Phillip J. Hsu, Sigrid Nachtergaele, Chengjie Ma, Renhua Song, Alejandro Fuentes-Iglesias, Bouchra Hassabi, Pascale Putmans, Frédérique Mies, Gerben Menschaert, Justin J. L. Wong, Jianlong Wang, Miguel Fidalgo, Bifeng Yuan, François Fuks
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9305faa1ca904cdba667b6f5f1a6c75f
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spelling	oai:doaj.org-article:9305faa1ca904cdba667b6f5f1a6c75f2021-12-02T19:17:00ZFunctional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation10.1038/s41467-020-18729-62041-1723https://doaj.org/article/9305faa1ca904cdba667b6f5f1a6c75f2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18729-6https://doaj.org/toc/2041-1723TET mediated RNA-hydroxymethylation (5hmC) has been detected in mammals, but its physiological role remains unclear. Here the authors map 5hmC during embryonic stem cell (ESC) differentiation and find that Tet-mediated RNA hydroxymethylation reduces the stability of crucial pluripotency related transcripts.Jie LanNicholas RajanMartin BizetAudrey PenningNitesh K. SinghDiana GuallarEmilie CalonneAndrea Li GreciElise BonvinRachel DeplusPhillip J. HsuSigrid NachtergaeleChengjie MaRenhua SongAlejandro Fuentes-IglesiasBouchra HassabiPascale PutmansFrédérique MiesGerben MenschaertJustin J. L. WongJianlong WangMiguel FidalgoBifeng YuanFrançois FuksNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jie Lan Nicholas Rajan Martin Bizet Audrey Penning Nitesh K. Singh Diana Guallar Emilie Calonne Andrea Li Greci Elise Bonvin Rachel Deplus Phillip J. Hsu Sigrid Nachtergaele Chengjie Ma Renhua Song Alejandro Fuentes-Iglesias Bouchra Hassabi Pascale Putmans Frédérique Mies Gerben Menschaert Justin J. L. Wong Jianlong Wang Miguel Fidalgo Bifeng Yuan François Fuks Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation
description	TET mediated RNA-hydroxymethylation (5hmC) has been detected in mammals, but its physiological role remains unclear. Here the authors map 5hmC during embryonic stem cell (ESC) differentiation and find that Tet-mediated RNA hydroxymethylation reduces the stability of crucial pluripotency related transcripts.
format	article
author	Jie Lan Nicholas Rajan Martin Bizet Audrey Penning Nitesh K. Singh Diana Guallar Emilie Calonne Andrea Li Greci Elise Bonvin Rachel Deplus Phillip J. Hsu Sigrid Nachtergaele Chengjie Ma Renhua Song Alejandro Fuentes-Iglesias Bouchra Hassabi Pascale Putmans Frédérique Mies Gerben Menschaert Justin J. L. Wong Jianlong Wang Miguel Fidalgo Bifeng Yuan François Fuks
author_facet	Jie Lan Nicholas Rajan Martin Bizet Audrey Penning Nitesh K. Singh Diana Guallar Emilie Calonne Andrea Li Greci Elise Bonvin Rachel Deplus Phillip J. Hsu Sigrid Nachtergaele Chengjie Ma Renhua Song Alejandro Fuentes-Iglesias Bouchra Hassabi Pascale Putmans Frédérique Mies Gerben Menschaert Justin J. L. Wong Jianlong Wang Miguel Fidalgo Bifeng Yuan François Fuks
author_sort	Jie Lan
title	Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation
title_short	Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation
title_full	Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation
title_fullStr	Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation
title_full_unstemmed	Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation
title_sort	functional role of tet-mediated rna hydroxymethylcytosine in mouse es cells and during differentiation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9305faa1ca904cdba667b6f5f1a6c75f
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Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation

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