Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease

The adipokine leptin modulates intestinal inflammation in mice. Here the authors describe a patient with inflammatory bowel disease and lipodystrophy, providing evidence that leptin aggravates intestinal inflammation with proinflammatory effects on leukocytes that are reversible by TNFα blockade.

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Autores principales:	Jörn F. Ziegler, Chotima Böttcher, Marilena Letizia, Cansu Yerinde, Hao Wu, Inka Freise, Yasmina Rodriguez-Sillke, Ani K. Stoyanova, Martin E. Kreis, Patrick Asbach, Desiree Kunkel, Josef Priller, Ioannis Anagnostopoulos, Anja A. Kühl, Konstanze Miehle, Michael Stumvoll, Florian Tran, Broder Fredrich, Michael Forster, Andre Franke, Christian Bojarski, Rainer Glauben, Britt-Sabina Löscher, Britta Siegmund, Carl Weidinger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/930d669ed7b944499b66502ad66aa5e6
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spelling	oai:doaj.org-article:930d669ed7b944499b66502ad66aa5e62021-12-02T15:35:09ZLeptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease10.1038/s41467-019-13559-72041-1723https://doaj.org/article/930d669ed7b944499b66502ad66aa5e62019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13559-7https://doaj.org/toc/2041-1723The adipokine leptin modulates intestinal inflammation in mice. Here the authors describe a patient with inflammatory bowel disease and lipodystrophy, providing evidence that leptin aggravates intestinal inflammation with proinflammatory effects on leukocytes that are reversible by TNFα blockade.Jörn F. ZieglerChotima BöttcherMarilena LetiziaCansu YerindeHao WuInka FreiseYasmina Rodriguez-SillkeAni K. StoyanovaMartin E. KreisPatrick AsbachDesiree KunkelJosef PrillerIoannis AnagnostopoulosAnja A. KühlKonstanze MiehleMichael StumvollFlorian TranBroder FredrichMichael ForsterAndre FrankeChristian BojarskiRainer GlaubenBritt-Sabina LöscherBritta SiegmundCarl WeidingerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jörn F. Ziegler Chotima Böttcher Marilena Letizia Cansu Yerinde Hao Wu Inka Freise Yasmina Rodriguez-Sillke Ani K. Stoyanova Martin E. Kreis Patrick Asbach Desiree Kunkel Josef Priller Ioannis Anagnostopoulos Anja A. Kühl Konstanze Miehle Michael Stumvoll Florian Tran Broder Fredrich Michael Forster Andre Franke Christian Bojarski Rainer Glauben Britt-Sabina Löscher Britta Siegmund Carl Weidinger Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease
description	The adipokine leptin modulates intestinal inflammation in mice. Here the authors describe a patient with inflammatory bowel disease and lipodystrophy, providing evidence that leptin aggravates intestinal inflammation with proinflammatory effects on leukocytes that are reversible by TNFα blockade.
format	article
author	Jörn F. Ziegler Chotima Böttcher Marilena Letizia Cansu Yerinde Hao Wu Inka Freise Yasmina Rodriguez-Sillke Ani K. Stoyanova Martin E. Kreis Patrick Asbach Desiree Kunkel Josef Priller Ioannis Anagnostopoulos Anja A. Kühl Konstanze Miehle Michael Stumvoll Florian Tran Broder Fredrich Michael Forster Andre Franke Christian Bojarski Rainer Glauben Britt-Sabina Löscher Britta Siegmund Carl Weidinger
author_facet	Jörn F. Ziegler Chotima Böttcher Marilena Letizia Cansu Yerinde Hao Wu Inka Freise Yasmina Rodriguez-Sillke Ani K. Stoyanova Martin E. Kreis Patrick Asbach Desiree Kunkel Josef Priller Ioannis Anagnostopoulos Anja A. Kühl Konstanze Miehle Michael Stumvoll Florian Tran Broder Fredrich Michael Forster Andre Franke Christian Bojarski Rainer Glauben Britt-Sabina Löscher Britta Siegmund Carl Weidinger
author_sort	Jörn F. Ziegler
title	Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease
title_short	Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease
title_full	Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease
title_fullStr	Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease
title_full_unstemmed	Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease
title_sort	leptin induces tnfα-dependent inflammation in acquired generalized lipodystrophy and combined crohn’s disease
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/930d669ed7b944499b66502ad66aa5e6
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Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease

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