Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol

Qun Cheng,1–3 Xiaoxing Wu,1,2 Yanping Du,1–3 Wei Hong,1–3 Wenjing Tang,1–3 Huilin Li,1–3 Minmin Chen,1–3 Songbai Zheng3 1Department of Osteoporosis and Bone Disease, Huadong Hospital Affiliated to Fudan University, Shanghai, China; 2Resear...

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Autores principales:	Cheng Q, Wu X, Du Y, Hong W, Tang W, Li H, Chen M, Zheng S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	calcitriol FGF-23 handgrip iPTH sclerosin Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/930ef2f4e068406cb0deaac6cc2c854f
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spelling	oai:doaj.org-article:930ef2f4e068406cb0deaac6cc2c854f2021-12-02T01:18:06ZLevels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol1178-1998https://doaj.org/article/930ef2f4e068406cb0deaac6cc2c854f2018-11-01T00:00:00Zhttps://www.dovepress.com/levels-of-serum-sclerostin-fgf-23-and-intact-parathyroid-hormone-in-po-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Qun Cheng,1–3 Xiaoxing Wu,1,2 Yanping Du,1–3 Wei Hong,1–3 Wenjing Tang,1–3 Huilin Li,1–3 Minmin Chen,1–3 Songbai Zheng3 1Department of Osteoporosis and Bone Disease, Huadong Hospital Affiliated to Fudan University, Shanghai, China; 2Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Shanghai, China; 3National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China Objective: This study aimed to determine the effect of calcitriol on serum concentrations of fibroblast growth factor-23 (FGF-23), sclerostin, intact parathyroid hormone (PTH), and handgrip strength in postmenopausal women with low bone mass.Methods: A randomized, double-blind controlled trial was carried out among 141 postmenopausal women with low bone mass. Participants were randomized into two groups: 75 participants received calcitriol 0.5 μg/day and 66 participants received a placebo for 12 weeks.Results: After 12-week calcitriol treatment, significant decreases in serum intact PTH (P=0.035) and sclerostin (P=0.039), as well as significant increases in serum creatinine (P=0.027), uric acid (P=0.032), 24-hour urinary calcium (P=0.0026), and left handgrip strength (P=0.03), were observed, compared to placebo group. Level of serum sclerostin was weakly but significantly positively correlated with serum PTH (r=0.277; P=0.01) and negatively correlated with 24-hour urinary calcium (r=−0.221; P=0.04) and left handgrip strength (r=−0.338; P=0.03) after calcitriol treatment. Multiple regression analysis demonstrated that decrease in serum sclerostin was associated with decrease in PTH serum level after calcitriol treatment (OR, 7.90; 95% CI, 2.28–27.42; P=0.002). However, no significant change in FGF-23 level was observed after calcitriol treatment.Conclusion: Calcitriol treatment yields a considerable decrease in serum sclerostin and significant increase of handgrip strength, and the change in serum sclerostin is regulated by serum PTH and by muscle strength. Keywords: calcitriol, FGF-23, fibroblast growth factor 23, handgrip, intact PTH, sclerostin Cheng QWu XDu YHong WTang WLi HChen MZheng SDove Medical PressarticlecalcitriolFGF-23handgripiPTHsclerosinGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 2367-2374 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcitriol FGF-23 handgrip iPTH sclerosin Geriatrics RC952-954.6
spellingShingle	calcitriol FGF-23 handgrip iPTH sclerosin Geriatrics RC952-954.6 Cheng Q Wu X Du Y Hong W Tang W Li H Chen M Zheng S Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol
description	Qun Cheng,1–3 Xiaoxing Wu,1,2 Yanping Du,1–3 Wei Hong,1–3 Wenjing Tang,1–3 Huilin Li,1–3 Minmin Chen,1–3 Songbai Zheng3 1Department of Osteoporosis and Bone Disease, Huadong Hospital Affiliated to Fudan University, Shanghai, China; 2Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Shanghai, China; 3National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China Objective: This study aimed to determine the effect of calcitriol on serum concentrations of fibroblast growth factor-23 (FGF-23), sclerostin, intact parathyroid hormone (PTH), and handgrip strength in postmenopausal women with low bone mass.Methods: A randomized, double-blind controlled trial was carried out among 141 postmenopausal women with low bone mass. Participants were randomized into two groups: 75 participants received calcitriol 0.5 μg/day and 66 participants received a placebo for 12 weeks.Results: After 12-week calcitriol treatment, significant decreases in serum intact PTH (P=0.035) and sclerostin (P=0.039), as well as significant increases in serum creatinine (P=0.027), uric acid (P=0.032), 24-hour urinary calcium (P=0.0026), and left handgrip strength (P=0.03), were observed, compared to placebo group. Level of serum sclerostin was weakly but significantly positively correlated with serum PTH (r=0.277; P=0.01) and negatively correlated with 24-hour urinary calcium (r=−0.221; P=0.04) and left handgrip strength (r=−0.338; P=0.03) after calcitriol treatment. Multiple regression analysis demonstrated that decrease in serum sclerostin was associated with decrease in PTH serum level after calcitriol treatment (OR, 7.90; 95% CI, 2.28–27.42; P=0.002). However, no significant change in FGF-23 level was observed after calcitriol treatment.Conclusion: Calcitriol treatment yields a considerable decrease in serum sclerostin and significant increase of handgrip strength, and the change in serum sclerostin is regulated by serum PTH and by muscle strength. Keywords: calcitriol, FGF-23, fibroblast growth factor 23, handgrip, intact PTH, sclerostin
format	article
author	Cheng Q Wu X Du Y Hong W Tang W Li H Chen M Zheng S
author_facet	Cheng Q Wu X Du Y Hong W Tang W Li H Chen M Zheng S
author_sort	Cheng Q
title	Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol
title_short	Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol
title_full	Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol
title_fullStr	Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol
title_full_unstemmed	Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol
title_sort	levels of serum sclerostin, fgf-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/930ef2f4e068406cb0deaac6cc2c854f
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Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol

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