CT changes of severe coronavirus disease 2019 based on prognosis

Abstract This study aimed to determine the characteristics of CT changes in patients with severe coronavirus disease 2019 (COVID-19) based on prognosis. Serial CT scans in 47 patients with severe COVID-19 were reviewed. The patterns, distribution and CT score of lung abnormalities were assessed. Sca...

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Autores principales:	Bin Liang, Lingli Xie, Fan Yang, Joyman Makamure, Lijie Zhang, Ran Pang, Peng Du, Wenhui Fan, Chuansheng Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9314836d05214600a61dd979c782c5fa
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spelling	oai:doaj.org-article:9314836d05214600a61dd979c782c5fa2021-12-02T12:42:18ZCT changes of severe coronavirus disease 2019 based on prognosis10.1038/s41598-020-78965-02045-2322https://doaj.org/article/9314836d05214600a61dd979c782c5fa2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78965-0https://doaj.org/toc/2045-2322Abstract This study aimed to determine the characteristics of CT changes in patients with severe coronavirus disease 2019 (COVID-19) based on prognosis. Serial CT scans in 47 patients with severe COVID-19 were reviewed. The patterns, distribution and CT score of lung abnormalities were assessed. Scans were classified according to duration in weeks after onset of symptoms. These CT abnormalities were compared between discharged and dead patients. Twenty-six patients were discharged, whereas 21 passed away. Discharged patients were characterized by a rapid rise in CT score in the first 2 weeks followed by a slow decline, presence of reticular and mixed patterns from the second week, and prevalence of subpleural distribution of opacities in all weeks. In contrast, dead patients were characterized by a progressive rise in CT score, persistence of ground-glass opacity and consolidation patterns in all weeks, and prevalence of diffuse distribution from the second week. CT scores of death group were significantly higher than those of discharge group (P < 0.05). The CT changes differed between the discharged and dead patients. An understanding of these differences can be of clinical significance in the assessment of the prognosis of severe COVID-19 patients.Bin LiangLingli XieFan YangJoyman MakamureLijie ZhangRan PangPeng DuWenhui FanChuansheng ZhengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bin Liang Lingli Xie Fan Yang Joyman Makamure Lijie Zhang Ran Pang Peng Du Wenhui Fan Chuansheng Zheng CT changes of severe coronavirus disease 2019 based on prognosis
description	Abstract This study aimed to determine the characteristics of CT changes in patients with severe coronavirus disease 2019 (COVID-19) based on prognosis. Serial CT scans in 47 patients with severe COVID-19 were reviewed. The patterns, distribution and CT score of lung abnormalities were assessed. Scans were classified according to duration in weeks after onset of symptoms. These CT abnormalities were compared between discharged and dead patients. Twenty-six patients were discharged, whereas 21 passed away. Discharged patients were characterized by a rapid rise in CT score in the first 2 weeks followed by a slow decline, presence of reticular and mixed patterns from the second week, and prevalence of subpleural distribution of opacities in all weeks. In contrast, dead patients were characterized by a progressive rise in CT score, persistence of ground-glass opacity and consolidation patterns in all weeks, and prevalence of diffuse distribution from the second week. CT scores of death group were significantly higher than those of discharge group (P < 0.05). The CT changes differed between the discharged and dead patients. An understanding of these differences can be of clinical significance in the assessment of the prognosis of severe COVID-19 patients.
format	article
author	Bin Liang Lingli Xie Fan Yang Joyman Makamure Lijie Zhang Ran Pang Peng Du Wenhui Fan Chuansheng Zheng
author_facet	Bin Liang Lingli Xie Fan Yang Joyman Makamure Lijie Zhang Ran Pang Peng Du Wenhui Fan Chuansheng Zheng
author_sort	Bin Liang
title	CT changes of severe coronavirus disease 2019 based on prognosis
title_short	CT changes of severe coronavirus disease 2019 based on prognosis
title_full	CT changes of severe coronavirus disease 2019 based on prognosis
title_fullStr	CT changes of severe coronavirus disease 2019 based on prognosis
title_full_unstemmed	CT changes of severe coronavirus disease 2019 based on prognosis
title_sort	ct changes of severe coronavirus disease 2019 based on prognosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9314836d05214600a61dd979c782c5fa
work_keys_str_mv	AT binliang ctchangesofseverecoronavirusdisease2019basedonprognosis AT linglixie ctchangesofseverecoronavirusdisease2019basedonprognosis AT fanyang ctchangesofseverecoronavirusdisease2019basedonprognosis AT joymanmakamure ctchangesofseverecoronavirusdisease2019basedonprognosis AT lijiezhang ctchangesofseverecoronavirusdisease2019basedonprognosis AT ranpang ctchangesofseverecoronavirusdisease2019basedonprognosis AT pengdu ctchangesofseverecoronavirusdisease2019basedonprognosis AT wenhuifan ctchangesofseverecoronavirusdisease2019basedonprognosis AT chuanshengzheng ctchangesofseverecoronavirusdisease2019basedonprognosis
_version_	1718393698665889792

CT changes of severe coronavirus disease 2019 based on prognosis

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