Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.

<h4>Background</h4>Chinese herbs are thought to be effective for type A H1N1 influenza. Series of Chinese herbs have been authorized recommended by the Chinese government, and until now a number of clinical trials of Chinese herbs for H1N1 influenza have been conducted. However, there is...

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Autores principales:	Wei Chen, Chi Eung Danforn Lim, Hong-Jun Kang, Jianping Liu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9314c28c381747a18b03eafde87a8c0b
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spelling	oai:doaj.org-article:9314c28c381747a18b03eafde87a8c0b2021-12-02T20:11:42ZChinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.1932-620310.1371/journal.pone.0028093https://doaj.org/article/9314c28c381747a18b03eafde87a8c0b2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22164232/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Chinese herbs are thought to be effective for type A H1N1 influenza. Series of Chinese herbs have been authorized recommended by the Chinese government, and until now a number of clinical trials of Chinese herbs for H1N1 influenza have been conducted. However, there is no critically appraised evidence such as systematic reviews or meta-analyses on potential benefits and harms of medicinal herbs for H1N1 influenza to justify their clinical use and their recommendation.<h4>Methods and findings</h4>CENTRAL, MEDLINE, EMBASE, CBM, CNKI, VIP, China Important Conference Papers Database, China Dissertation Database, and online clinical trial registry websites were searched for published and unpublished randomized controlled trials (RCTs) of Chinese herbs for H1N1 influenza till 31 August, 2011. A total of 26 RCTs were identified and reviewed. Most of the RCTs were of high risk of bias with flawed study design and poor methodological quality. The combination of several Chinese herbal medicines with or without oseltamivir demonstrated positive effect on fever resolution, relief of symptoms, and global effectiveness rate compared to oseltamivir alone. However, only one herbal medicine showed positive effect on viral shedding. Most of the trials did not report adverse events, and the safety of herbal medicines is still uncertain.<h4>Conclusions</h4>Some Chinese herbal medicines demonstrated potential positive effect for 2009 type A H1N1 influenza; however, due to the lack of placebo controlled trial and lack of repeated test of the intervention, we could not draw confirmative conclusions on the beneficial effect of Chinese herbs for H1N1 influenza. More rigorous trials are warranted to support their clinical use.Wei ChenChi Eung Danforn LimHong-Jun KangJianping LiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e28093 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Chen Chi Eung Danforn Lim Hong-Jun Kang Jianping Liu Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.
description	<h4>Background</h4>Chinese herbs are thought to be effective for type A H1N1 influenza. Series of Chinese herbs have been authorized recommended by the Chinese government, and until now a number of clinical trials of Chinese herbs for H1N1 influenza have been conducted. However, there is no critically appraised evidence such as systematic reviews or meta-analyses on potential benefits and harms of medicinal herbs for H1N1 influenza to justify their clinical use and their recommendation.<h4>Methods and findings</h4>CENTRAL, MEDLINE, EMBASE, CBM, CNKI, VIP, China Important Conference Papers Database, China Dissertation Database, and online clinical trial registry websites were searched for published and unpublished randomized controlled trials (RCTs) of Chinese herbs for H1N1 influenza till 31 August, 2011. A total of 26 RCTs were identified and reviewed. Most of the RCTs were of high risk of bias with flawed study design and poor methodological quality. The combination of several Chinese herbal medicines with or without oseltamivir demonstrated positive effect on fever resolution, relief of symptoms, and global effectiveness rate compared to oseltamivir alone. However, only one herbal medicine showed positive effect on viral shedding. Most of the trials did not report adverse events, and the safety of herbal medicines is still uncertain.<h4>Conclusions</h4>Some Chinese herbal medicines demonstrated potential positive effect for 2009 type A H1N1 influenza; however, due to the lack of placebo controlled trial and lack of repeated test of the intervention, we could not draw confirmative conclusions on the beneficial effect of Chinese herbs for H1N1 influenza. More rigorous trials are warranted to support their clinical use.
format	article
author	Wei Chen Chi Eung Danforn Lim Hong-Jun Kang Jianping Liu
author_facet	Wei Chen Chi Eung Danforn Lim Hong-Jun Kang Jianping Liu
author_sort	Wei Chen
title	Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.
title_short	Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.
title_full	Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.
title_fullStr	Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.
title_full_unstemmed	Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.
title_sort	chinese herbal medicines for the treatment of type a h1n1 influenza: a systematic review of randomized controlled trials.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/9314c28c381747a18b03eafde87a8c0b
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Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.

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