STRUCTURE AND IMMUNE ADJUVANT PROPERTIES OF CPG-D

Bacterial DNA, along with other bacterial pathogen-associated molecular structures, may activate both innate and adaptive immune systems. This activity is associated with by nonmethylated CpG dinucleotides, which are present in the bDNA molecule, and it may be simulated by synthetic CpG oligodeoxynu...

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Autores principales:	V. S. Polovinkina, E. Yu. Markov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	bacterial dna toll-like receptors cpg dinucleotide adjuvant effects Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/93179e338e684fd18290aab97e7ebe60
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spelling	oai:doaj.org-article:93179e338e684fd18290aab97e7ebe602021-11-18T08:03:41ZSTRUCTURE AND IMMUNE ADJUVANT PROPERTIES OF CPG-D1563-06252313-741X10.15789/1563-0625-2010-6-469-476https://doaj.org/article/93179e338e684fd18290aab97e7ebe602014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/417https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XBacterial DNA, along with other bacterial pathogen-associated molecular structures, may activate both innate and adaptive immune systems. This activity is associated with by nonmethylated CpG dinucleotides, which are present in the bDNA molecule, and it may be simulated by synthetic CpG oligodeoxynucleotides (ODNs). Non-methylated CpG motifs are recognized by Toll-like receptor 9 that triggers the induction of cell signaling pathways, activating proinflammatory cytokine synthesis by immune competent cells, and triggering the immune protection mechanisms. In present review we consider structure, functions, adjuvant features, immune properties and potential clinical applications of bacterial DNA and various classes of synthetic non-methylated CpG-ODNs.V. S. PolovinkinaE. Yu. MarkovSPb RAACIarticlebacterial dnatoll-like receptorscpg dinucleotideadjuvant effectsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 6, Pp 469-476 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	bacterial dna toll-like receptors cpg dinucleotide adjuvant effects Immunologic diseases. Allergy RC581-607
spellingShingle	bacterial dna toll-like receptors cpg dinucleotide adjuvant effects Immunologic diseases. Allergy RC581-607 V. S. Polovinkina E. Yu. Markov STRUCTURE AND IMMUNE ADJUVANT PROPERTIES OF CPG-D
description	Bacterial DNA, along with other bacterial pathogen-associated molecular structures, may activate both innate and adaptive immune systems. This activity is associated with by nonmethylated CpG dinucleotides, which are present in the bDNA molecule, and it may be simulated by synthetic CpG oligodeoxynucleotides (ODNs). Non-methylated CpG motifs are recognized by Toll-like receptor 9 that triggers the induction of cell signaling pathways, activating proinflammatory cytokine synthesis by immune competent cells, and triggering the immune protection mechanisms. In present review we consider structure, functions, adjuvant features, immune properties and potential clinical applications of bacterial DNA and various classes of synthetic non-methylated CpG-ODNs.
format	article
author	V. S. Polovinkina E. Yu. Markov
author_facet	V. S. Polovinkina E. Yu. Markov
author_sort	V. S. Polovinkina
title	STRUCTURE AND IMMUNE ADJUVANT PROPERTIES OF CPG-D
title_short	STRUCTURE AND IMMUNE ADJUVANT PROPERTIES OF CPG-D
title_full	STRUCTURE AND IMMUNE ADJUVANT PROPERTIES OF CPG-D
title_fullStr	STRUCTURE AND IMMUNE ADJUVANT PROPERTIES OF CPG-D
title_full_unstemmed	STRUCTURE AND IMMUNE ADJUVANT PROPERTIES OF CPG-D
title_sort	structure and immune adjuvant properties of cpg-d
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/93179e338e684fd18290aab97e7ebe60
work_keys_str_mv	AT vspolovinkina structureandimmuneadjuvantpropertiesofcpgd AT eyumarkov structureandimmuneadjuvantpropertiesofcpgd
_version_	1718422493129080832

STRUCTURE AND IMMUNE ADJUVANT PROPERTIES OF CPG-D

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