Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication

High-risk human papillomaviruses (HPVs) infect epithelial cells and induce viral genome amplification upon differentiation. HPV proteins activate DNA damage repair pathways by inducing high numbers of DNA breaks in both viral and cellular DNAs.

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Autores principales:	Paul Kaminski, Shiyuan Hong, Takeyuki Kono, Paul Hoover, Laimonis Laimins
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/931932cf45334cafbae817683388301c
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spelling	oai:doaj.org-article:931932cf45334cafbae817683388301c2021-11-03T18:15:37ZTopoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication2161-21292150-751110.1128/mBio.00005-21https://doaj.org/article/931932cf45334cafbae817683388301c2021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00005-21https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 High-risk human papillomaviruses (HPVs) infect epithelial cells and induce viral genome amplification upon differentiation. HPV proteins activate DNA damage repair pathways by inducing high numbers of DNA breaks in both viral and cellular DNAs.Paul KaminskiShiyuan HongTakeyuki KonoPaul HooverLaimonis LaiminsAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Paul Kaminski Shiyuan Hong Takeyuki Kono Paul Hoover Laimonis Laimins Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication
description	High-risk human papillomaviruses (HPVs) infect epithelial cells and induce viral genome amplification upon differentiation. HPV proteins activate DNA damage repair pathways by inducing high numbers of DNA breaks in both viral and cellular DNAs.
format	article
author	Paul Kaminski Shiyuan Hong Takeyuki Kono Paul Hoover Laimonis Laimins
author_facet	Paul Kaminski Shiyuan Hong Takeyuki Kono Paul Hoover Laimonis Laimins
author_sort	Paul Kaminski
title	Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication
title_short	Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication
title_full	Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication
title_fullStr	Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication
title_full_unstemmed	Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication
title_sort	topoisomerase 2β induces dna breaks to regulate human papillomavirus replication
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/931932cf45334cafbae817683388301c
work_keys_str_mv	AT paulkaminski topoisomerase2binducesdnabreakstoregulatehumanpapillomavirusreplication AT shiyuanhong topoisomerase2binducesdnabreakstoregulatehumanpapillomavirusreplication AT takeyukikono topoisomerase2binducesdnabreakstoregulatehumanpapillomavirusreplication AT paulhoover topoisomerase2binducesdnabreakstoregulatehumanpapillomavirusreplication AT laimonislaimins topoisomerase2binducesdnabreakstoregulatehumanpapillomavirusreplication
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Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication

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