Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

Fibroblasts are found to be heterogeneous in multiple fibrotic diseases, but fibroblast heterogeneity in fibrotic skin diseases is not well characterized. Here the authors employ scRNA-seq to explore fibroblast heterogeneity in keloid, a paradigm of fibrotic skin diseases.

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Autores principales:	Cheng-Cheng Deng, Yong-Fei Hu, Ding-Heng Zhu, Qing Cheng, Jing-Jing Gu, Qing-Lan Feng, Li-Xue Zhang, Ying-Ping Xu, Dong Wang, Zhili Rong, Bin Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/931947cadf6f42f79b721eb90ccae947
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spelling	oai:doaj.org-article:931947cadf6f42f79b721eb90ccae9472021-12-02T17:40:28ZSingle-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases10.1038/s41467-021-24110-y2041-1723https://doaj.org/article/931947cadf6f42f79b721eb90ccae9472021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24110-yhttps://doaj.org/toc/2041-1723Fibroblasts are found to be heterogeneous in multiple fibrotic diseases, but fibroblast heterogeneity in fibrotic skin diseases is not well characterized. Here the authors employ scRNA-seq to explore fibroblast heterogeneity in keloid, a paradigm of fibrotic skin diseases.Cheng-Cheng DengYong-Fei HuDing-Heng ZhuQing ChengJing-Jing GuQing-Lan FengLi-Xue ZhangYing-Ping XuDong WangZhili RongBin YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cheng-Cheng Deng Yong-Fei Hu Ding-Heng Zhu Qing Cheng Jing-Jing Gu Qing-Lan Feng Li-Xue Zhang Ying-Ping Xu Dong Wang Zhili Rong Bin Yang Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
description	Fibroblasts are found to be heterogeneous in multiple fibrotic diseases, but fibroblast heterogeneity in fibrotic skin diseases is not well characterized. Here the authors employ scRNA-seq to explore fibroblast heterogeneity in keloid, a paradigm of fibrotic skin diseases.
format	article
author	Cheng-Cheng Deng Yong-Fei Hu Ding-Heng Zhu Qing Cheng Jing-Jing Gu Qing-Lan Feng Li-Xue Zhang Ying-Ping Xu Dong Wang Zhili Rong Bin Yang
author_facet	Cheng-Cheng Deng Yong-Fei Hu Ding-Heng Zhu Qing Cheng Jing-Jing Gu Qing-Lan Feng Li-Xue Zhang Ying-Ping Xu Dong Wang Zhili Rong Bin Yang
author_sort	Cheng-Cheng Deng
title	Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
title_short	Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
title_full	Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
title_fullStr	Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
title_full_unstemmed	Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
title_sort	single-cell rna-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/931947cadf6f42f79b721eb90ccae947
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Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

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