Significance of radiation esophagitis: Conditional survival assessment in patients with non-small cell lung cancer

Purpose: This study aimed to examine the effect of radiation esophagitis (RE) and the dynamics of RE on subsequent survival in non-small cell lung cancer (NSCLC) patients who underwent radiotherapy. Experimental Design: Patients with NSCLC treated with fractionated thoracic radiotherapy enrolled in...

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Autores principales:	Hao Yu, Ka-On Lam, Michael D. Green, Huanmei Wu, Li Yang, Weili Wang, Jianyue Jin, Chen Hu, Yang Wang, Shruti Jolly, Feng-Ming (Spring) Kong
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Radiotherapy Radiation esophagitis Conditional survival Non-small cell lung cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9319e04b9edc47d0968fd45d7f5dcdbb
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spelling	oai:doaj.org-article:9319e04b9edc47d0968fd45d7f5dcdbb2021-12-01T05:06:36ZSignificance of radiation esophagitis: Conditional survival assessment in patients with non-small cell lung cancer2667-005410.1016/j.jncc.2021.02.003https://doaj.org/article/9319e04b9edc47d0968fd45d7f5dcdbb2021-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667005421000077https://doaj.org/toc/2667-0054Purpose: This study aimed to examine the effect of radiation esophagitis (RE) and the dynamics of RE on subsequent survival in non-small cell lung cancer (NSCLC) patients who underwent radiotherapy. Experimental Design: Patients with NSCLC treated with fractionated thoracic radiotherapy enrolled in prospective trials were eligible. RE was graded prospectively according to Common Terminology Criteria for Adverse Events (CTCAE) v3.0 per protocol requirement weekly during-RT and 1 month after RT. This study applied conditional survival assessment which has advantage over traditional survival analysis as it assesses the survival from the event instead of from the baseline. P-value less than 0.05 was considered to be significant. The primary endpoint is overall survival. Results: A total of 177 patients were eligible, with a median follow-up of 5 years. The presence of RE, the maximum RE grade, the evolution of RE and the onset timing of RE events were all correlated with subsequent survival. At all conditional time points, patients first presented with RE grade1 (initial RE1) had significant inferior subsequent survival (multivariable HRs median: 1.63, all P-values<0.05); meanwhile those with RE progressed had significant inferior subsequent survival than those never develop RE (multivariable HRs median: 2.08, all P-values<0.05). Multivariable Cox proportional-hazards analysis showed significantly higher C-indexes for models with inclusion of RE events than those without (all P-values<0.05). Conclusion: This study comprehensively evaluated the impact of RE with conditional survival assessment and demonstrated that RE is associated with inferior survival in NSCLC patients treated with RT.Hao YuKa-On LamMichael D. GreenHuanmei WuLi YangWeili WangJianyue JinChen HuYang WangShruti JollyFeng-Ming (Spring) KongElsevierarticleRadiotherapyRadiation esophagitisConditional survivalNon-small cell lung cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of the National Cancer Center, Vol 1, Iss 2, Pp 31-38 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Radiotherapy Radiation esophagitis Conditional survival Non-small cell lung cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Radiotherapy Radiation esophagitis Conditional survival Non-small cell lung cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hao Yu Ka-On Lam Michael D. Green Huanmei Wu Li Yang Weili Wang Jianyue Jin Chen Hu Yang Wang Shruti Jolly Feng-Ming (Spring) Kong Significance of radiation esophagitis: Conditional survival assessment in patients with non-small cell lung cancer
description	Purpose: This study aimed to examine the effect of radiation esophagitis (RE) and the dynamics of RE on subsequent survival in non-small cell lung cancer (NSCLC) patients who underwent radiotherapy. Experimental Design: Patients with NSCLC treated with fractionated thoracic radiotherapy enrolled in prospective trials were eligible. RE was graded prospectively according to Common Terminology Criteria for Adverse Events (CTCAE) v3.0 per protocol requirement weekly during-RT and 1 month after RT. This study applied conditional survival assessment which has advantage over traditional survival analysis as it assesses the survival from the event instead of from the baseline. P-value less than 0.05 was considered to be significant. The primary endpoint is overall survival. Results: A total of 177 patients were eligible, with a median follow-up of 5 years. The presence of RE, the maximum RE grade, the evolution of RE and the onset timing of RE events were all correlated with subsequent survival. At all conditional time points, patients first presented with RE grade1 (initial RE1) had significant inferior subsequent survival (multivariable HRs median: 1.63, all P-values<0.05); meanwhile those with RE progressed had significant inferior subsequent survival than those never develop RE (multivariable HRs median: 2.08, all P-values<0.05). Multivariable Cox proportional-hazards analysis showed significantly higher C-indexes for models with inclusion of RE events than those without (all P-values<0.05). Conclusion: This study comprehensively evaluated the impact of RE with conditional survival assessment and demonstrated that RE is associated with inferior survival in NSCLC patients treated with RT.
format	article
author	Hao Yu Ka-On Lam Michael D. Green Huanmei Wu Li Yang Weili Wang Jianyue Jin Chen Hu Yang Wang Shruti Jolly Feng-Ming (Spring) Kong
author_facet	Hao Yu Ka-On Lam Michael D. Green Huanmei Wu Li Yang Weili Wang Jianyue Jin Chen Hu Yang Wang Shruti Jolly Feng-Ming (Spring) Kong
author_sort	Hao Yu
title	Significance of radiation esophagitis: Conditional survival assessment in patients with non-small cell lung cancer
title_short	Significance of radiation esophagitis: Conditional survival assessment in patients with non-small cell lung cancer
title_full	Significance of radiation esophagitis: Conditional survival assessment in patients with non-small cell lung cancer
title_fullStr	Significance of radiation esophagitis: Conditional survival assessment in patients with non-small cell lung cancer
title_full_unstemmed	Significance of radiation esophagitis: Conditional survival assessment in patients with non-small cell lung cancer
title_sort	significance of radiation esophagitis: conditional survival assessment in patients with non-small cell lung cancer
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9319e04b9edc47d0968fd45d7f5dcdbb
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Significance of radiation esophagitis: Conditional survival assessment in patients with non-small cell lung cancer

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