A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening

Functionalizing multiple, distant sites across a molecule is a challenge. Here the authors report a remote functionalization strategy, whereby an initial Heck reaction leads to chain-walking of palladium across a molecule, ring-opening cyclopropanes while retaining the stereochemistry in the product...

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Autores principales:	Sukhdev Singh, Jeffrey Bruffaerts, Alexandre Vasseur, Ilan Marek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9319fac62c524a47a88a61dc8a81b806
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id	oai:doaj.org-article:9319fac62c524a47a88a61dc8a81b806
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spelling	oai:doaj.org-article:9319fac62c524a47a88a61dc8a81b8062021-12-02T15:38:43ZA unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening10.1038/ncomms142002041-1723https://doaj.org/article/9319fac62c524a47a88a61dc8a81b8062017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14200https://doaj.org/toc/2041-1723Functionalizing multiple, distant sites across a molecule is a challenge. Here the authors report a remote functionalization strategy, whereby an initial Heck reaction leads to chain-walking of palladium across a molecule, ring-opening cyclopropanes while retaining the stereochemistry in the product.Sukhdev SinghJeffrey BruffaertsAlexandre VasseurIlan MarekNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sukhdev Singh Jeffrey Bruffaerts Alexandre Vasseur Ilan Marek A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening
description	Functionalizing multiple, distant sites across a molecule is a challenge. Here the authors report a remote functionalization strategy, whereby an initial Heck reaction leads to chain-walking of palladium across a molecule, ring-opening cyclopropanes while retaining the stereochemistry in the product.
format	article
author	Sukhdev Singh Jeffrey Bruffaerts Alexandre Vasseur Ilan Marek
author_facet	Sukhdev Singh Jeffrey Bruffaerts Alexandre Vasseur Ilan Marek
author_sort	Sukhdev Singh
title	A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening
title_short	A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening
title_full	A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening
title_fullStr	A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening
title_full_unstemmed	A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening
title_sort	unique pd-catalysed heck arylation as a remote trigger for cyclopropane selective ring-opening
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9319fac62c524a47a88a61dc8a81b806
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A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening

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