Heritable Bovine Rumen Bacteria Are Phylogenetically Related and Correlated with the Cow’s Capacity To Harvest Energy from Its Feed

ABSTRACT Ruminants sustain a long-lasting obligatory relationship with their rumen microbiome dating back 50 million years. In this unique host-microbiome relationship, the host’s ability to digest its feed is completely dependent on its coevolved microbiome. This extraordinary alliance raises quest...

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Autores principales:	Goor Sasson, Sheerli Kruger Ben-Shabat, Eyal Seroussi, Adi Doron-Faigenboim, Naama Shterzer, Shamay Yaacoby, Margret E. Berg Miller, Bryan A. White, Eran Halperin, Itzhak Mizrahi
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	genetics host-microbe interaction microbial ecology microbiome rumen ecology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/93251fd1a3114e8185580b7d44ef8feb
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spelling	oai:doaj.org-article:93251fd1a3114e8185580b7d44ef8feb2021-11-15T15:51:44ZHeritable Bovine Rumen Bacteria Are Phylogenetically Related and Correlated with the Cow’s Capacity To Harvest Energy from Its Feed10.1128/mBio.00703-172150-7511https://doaj.org/article/93251fd1a3114e8185580b7d44ef8feb2017-09-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00703-17https://doaj.org/toc/2150-7511ABSTRACT Ruminants sustain a long-lasting obligatory relationship with their rumen microbiome dating back 50 million years. In this unique host-microbiome relationship, the host’s ability to digest its feed is completely dependent on its coevolved microbiome. This extraordinary alliance raises questions regarding the dependent relationship between ruminants’ genetics and physiology and the rumen microbiome structure, composition, and metabolism. To elucidate this relationship, we examined the association of host genetics with the phylogenetic and functional composition of the rumen microbiome. We accomplished this by studying a population of 78 Holstein-Friesian dairy cows, using a combination of rumen microbiota data and other phenotypes from each animal with genotypic data from a subset of 47 animals. We identified 22 operational taxonomic units (OTUs) whose abundances were associated with rumen metabolic traits and host physiological traits and which showed measurable heritability. The abundance patterns of these microbes can explain high proportions of variance in rumen metabolism and many of the host physiological attributes such as its energy-harvesting efficiency. Interestingly, these OTUs shared higher phylogenetic similarity between themselves than expected by chance, suggesting occupation of a specific ecological niche within the rumen ecosystem. The findings presented here suggest that ruminant genetics and physiology are correlated with microbiome structure and that host genetics may shape the microbiome landscape by enriching for phylogenetically related taxa that may occupy a unique niche. IMPORTANCE Dairy cows are an essential nutritional source for the world’s population; as such, they are extensively farmed throughout our planet and subsequently impact our environment. The microbial communities that reside in the upper digestive tract of these animals in a compartment named the rumen degrade and ferment the plant biomass that the animal ingests. Our recent efforts, as well as those of others, have shown that this microbial community’s composition and functionality are tightly linked to the cow’s capacity to harvest energy from its feed, as well as to other physiological traits. In this study, we identified microbial groups that are heritable and also linked to the cow’s production parameters. This finding could potentially allow us to apply selection programs on specific rumen microbial components that are linked to the animal’s physiology and beneficial to production. Hence, it is a steppingstone toward microbiome manipulation for increasing food availability while lowering environmental impacts such as methane emission.Goor SassonSheerli Kruger Ben-ShabatEyal SeroussiAdi Doron-FaigenboimNaama ShterzerShamay YaacobyMargret E. Berg MillerBryan A. WhiteEran HalperinItzhak MizrahiAmerican Society for Microbiologyarticlegeneticshost-microbe interactionmicrobial ecologymicrobiomerumen ecologyMicrobiologyQR1-502ENmBio, Vol 8, Iss 4 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	genetics host-microbe interaction microbial ecology microbiome rumen ecology Microbiology QR1-502
spellingShingle	genetics host-microbe interaction microbial ecology microbiome rumen ecology Microbiology QR1-502 Goor Sasson Sheerli Kruger Ben-Shabat Eyal Seroussi Adi Doron-Faigenboim Naama Shterzer Shamay Yaacoby Margret E. Berg Miller Bryan A. White Eran Halperin Itzhak Mizrahi Heritable Bovine Rumen Bacteria Are Phylogenetically Related and Correlated with the Cow’s Capacity To Harvest Energy from Its Feed
description	ABSTRACT Ruminants sustain a long-lasting obligatory relationship with their rumen microbiome dating back 50 million years. In this unique host-microbiome relationship, the host’s ability to digest its feed is completely dependent on its coevolved microbiome. This extraordinary alliance raises questions regarding the dependent relationship between ruminants’ genetics and physiology and the rumen microbiome structure, composition, and metabolism. To elucidate this relationship, we examined the association of host genetics with the phylogenetic and functional composition of the rumen microbiome. We accomplished this by studying a population of 78 Holstein-Friesian dairy cows, using a combination of rumen microbiota data and other phenotypes from each animal with genotypic data from a subset of 47 animals. We identified 22 operational taxonomic units (OTUs) whose abundances were associated with rumen metabolic traits and host physiological traits and which showed measurable heritability. The abundance patterns of these microbes can explain high proportions of variance in rumen metabolism and many of the host physiological attributes such as its energy-harvesting efficiency. Interestingly, these OTUs shared higher phylogenetic similarity between themselves than expected by chance, suggesting occupation of a specific ecological niche within the rumen ecosystem. The findings presented here suggest that ruminant genetics and physiology are correlated with microbiome structure and that host genetics may shape the microbiome landscape by enriching for phylogenetically related taxa that may occupy a unique niche. IMPORTANCE Dairy cows are an essential nutritional source for the world’s population; as such, they are extensively farmed throughout our planet and subsequently impact our environment. The microbial communities that reside in the upper digestive tract of these animals in a compartment named the rumen degrade and ferment the plant biomass that the animal ingests. Our recent efforts, as well as those of others, have shown that this microbial community’s composition and functionality are tightly linked to the cow’s capacity to harvest energy from its feed, as well as to other physiological traits. In this study, we identified microbial groups that are heritable and also linked to the cow’s production parameters. This finding could potentially allow us to apply selection programs on specific rumen microbial components that are linked to the animal’s physiology and beneficial to production. Hence, it is a steppingstone toward microbiome manipulation for increasing food availability while lowering environmental impacts such as methane emission.
format	article
author	Goor Sasson Sheerli Kruger Ben-Shabat Eyal Seroussi Adi Doron-Faigenboim Naama Shterzer Shamay Yaacoby Margret E. Berg Miller Bryan A. White Eran Halperin Itzhak Mizrahi
author_facet	Goor Sasson Sheerli Kruger Ben-Shabat Eyal Seroussi Adi Doron-Faigenboim Naama Shterzer Shamay Yaacoby Margret E. Berg Miller Bryan A. White Eran Halperin Itzhak Mizrahi
author_sort	Goor Sasson
title	Heritable Bovine Rumen Bacteria Are Phylogenetically Related and Correlated with the Cow’s Capacity To Harvest Energy from Its Feed
title_short	Heritable Bovine Rumen Bacteria Are Phylogenetically Related and Correlated with the Cow’s Capacity To Harvest Energy from Its Feed
title_full	Heritable Bovine Rumen Bacteria Are Phylogenetically Related and Correlated with the Cow’s Capacity To Harvest Energy from Its Feed
title_fullStr	Heritable Bovine Rumen Bacteria Are Phylogenetically Related and Correlated with the Cow’s Capacity To Harvest Energy from Its Feed
title_full_unstemmed	Heritable Bovine Rumen Bacteria Are Phylogenetically Related and Correlated with the Cow’s Capacity To Harvest Energy from Its Feed
title_sort	heritable bovine rumen bacteria are phylogenetically related and correlated with the cow’s capacity to harvest energy from its feed
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/93251fd1a3114e8185580b7d44ef8feb
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Heritable Bovine Rumen Bacteria Are Phylogenetically Related and Correlated with the Cow’s Capacity To Harvest Energy from Its Feed

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