Gold Nanorod-Decorated Metallic MoS<sub>2</sub> Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy
Light-responsive nanocomposites have become increasingly attractive in the biomedical field for antibacterial applications. Visible-light-activated metallic molybdenum disulfide nanosheets (1T-MoS<sub>2</sub> NSs) and plasmonic gold nanorods (AuNRs) with absorption at a wavelength of 808...
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| Autores principales: | , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/932b06cf44a54320aa18cc1bc3631402 |
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| Sumario: | Light-responsive nanocomposites have become increasingly attractive in the biomedical field for antibacterial applications. Visible-light-activated metallic molybdenum disulfide nanosheets (1T-MoS<sub>2</sub> NSs) and plasmonic gold nanorods (AuNRs) with absorption at a wavelength of 808 nm were synthesized. AuNR nanocomposites decorated onto 1T-MoS<sub>2</sub> NSs (MoS<sub>2</sub>@AuNRs) were successfully prepared by electrostatic adsorption for phototherapy applications. Based on the photothermal effect, the solution temperature of the MoS<sub>2</sub>@AuNR nanocomposites increased from 25 to 66.7 °C after 808 nm near-infrared (NIR) laser irradiation for 10 min. For the photodynamic effect, the MoS<sub>2</sub>@AuNR nanocomposites generated reactive oxygen species (ROS) under visible light irradiation. Photothermal therapy and photodynamic therapy of MoS<sub>2</sub>@AuNRs were confirmed against <i>E. coli</i> by agar plate counts. Most importantly, the combination of photothermal therapy and photodynamic therapy from the MoS<sub>2</sub>@AuNR nanocomposites revealed higher antibacterial activity than photothermal or photodynamic therapy alone. The light-activated MoS<sub>2</sub>@AuNR nanocomposites exhibited a remarkable synergistic effect of photothermal therapy and photodynamic therapy, which provides an alternative approach to fight bacterial infections. |
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