Gold Nanorod-Decorated Metallic MoS<sub>2</sub> Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy

Light-responsive nanocomposites have become increasingly attractive in the biomedical field for antibacterial applications. Visible-light-activated metallic molybdenum disulfide nanosheets (1T-MoS<sub>2</sub> NSs) and plasmonic gold nanorods (AuNRs) with absorption at a wavelength of 808...

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Autores principales:	Sibidou Yougbaré, Chinmaya Mutalik, Pei-Feng Chung, Dyah Ika Krisnawati, Fajar Rinawati, Hengky Irawan, Heny Kristanto, Tsung-Rong Kuo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antimicrobial activity gold nanorods metallic molybdenum disulfide phototherapy photothermal therapy photodynamic therapy Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/932b06cf44a54320aa18cc1bc3631402
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spelling	oai:doaj.org-article:932b06cf44a54320aa18cc1bc36314022021-11-25T18:32:10ZGold Nanorod-Decorated Metallic MoS<sub>2</sub> Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy10.3390/nano111130642079-4991https://doaj.org/article/932b06cf44a54320aa18cc1bc36314022021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/3064https://doaj.org/toc/2079-4991Light-responsive nanocomposites have become increasingly attractive in the biomedical field for antibacterial applications. Visible-light-activated metallic molybdenum disulfide nanosheets (1T-MoS<sub>2</sub> NSs) and plasmonic gold nanorods (AuNRs) with absorption at a wavelength of 808 nm were synthesized. AuNR nanocomposites decorated onto 1T-MoS<sub>2</sub> NSs (MoS<sub>2</sub>@AuNRs) were successfully prepared by electrostatic adsorption for phototherapy applications. Based on the photothermal effect, the solution temperature of the MoS<sub>2</sub>@AuNR nanocomposites increased from 25 to 66.7 °C after 808 nm near-infrared (NIR) laser irradiation for 10 min. For the photodynamic effect, the MoS<sub>2</sub>@AuNR nanocomposites generated reactive oxygen species (ROS) under visible light irradiation. Photothermal therapy and photodynamic therapy of MoS<sub>2</sub>@AuNRs were confirmed against <i>E. coli</i> by agar plate counts. Most importantly, the combination of photothermal therapy and photodynamic therapy from the MoS<sub>2</sub>@AuNR nanocomposites revealed higher antibacterial activity than photothermal or photodynamic therapy alone. The light-activated MoS<sub>2</sub>@AuNR nanocomposites exhibited a remarkable synergistic effect of photothermal therapy and photodynamic therapy, which provides an alternative approach to fight bacterial infections.Sibidou YougbaréChinmaya MutalikPei-Feng ChungDyah Ika KrisnawatiFajar RinawatiHengky IrawanHeny KristantoTsung-Rong KuoMDPI AGarticleantimicrobial activitygold nanorodsmetallic molybdenum disulfidephototherapyphotothermal therapyphotodynamic therapyChemistryQD1-999ENNanomaterials, Vol 11, Iss 3064, p 3064 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial activity gold nanorods metallic molybdenum disulfide phototherapy photothermal therapy photodynamic therapy Chemistry QD1-999
spellingShingle	antimicrobial activity gold nanorods metallic molybdenum disulfide phototherapy photothermal therapy photodynamic therapy Chemistry QD1-999 Sibidou Yougbaré Chinmaya Mutalik Pei-Feng Chung Dyah Ika Krisnawati Fajar Rinawati Hengky Irawan Heny Kristanto Tsung-Rong Kuo Gold Nanorod-Decorated Metallic MoS<sub>2</sub> Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy
description	Light-responsive nanocomposites have become increasingly attractive in the biomedical field for antibacterial applications. Visible-light-activated metallic molybdenum disulfide nanosheets (1T-MoS<sub>2</sub> NSs) and plasmonic gold nanorods (AuNRs) with absorption at a wavelength of 808 nm were synthesized. AuNR nanocomposites decorated onto 1T-MoS<sub>2</sub> NSs (MoS<sub>2</sub>@AuNRs) were successfully prepared by electrostatic adsorption for phototherapy applications. Based on the photothermal effect, the solution temperature of the MoS<sub>2</sub>@AuNR nanocomposites increased from 25 to 66.7 °C after 808 nm near-infrared (NIR) laser irradiation for 10 min. For the photodynamic effect, the MoS<sub>2</sub>@AuNR nanocomposites generated reactive oxygen species (ROS) under visible light irradiation. Photothermal therapy and photodynamic therapy of MoS<sub>2</sub>@AuNRs were confirmed against <i>E. coli</i> by agar plate counts. Most importantly, the combination of photothermal therapy and photodynamic therapy from the MoS<sub>2</sub>@AuNR nanocomposites revealed higher antibacterial activity than photothermal or photodynamic therapy alone. The light-activated MoS<sub>2</sub>@AuNR nanocomposites exhibited a remarkable synergistic effect of photothermal therapy and photodynamic therapy, which provides an alternative approach to fight bacterial infections.
format	article
author	Sibidou Yougbaré Chinmaya Mutalik Pei-Feng Chung Dyah Ika Krisnawati Fajar Rinawati Hengky Irawan Heny Kristanto Tsung-Rong Kuo
author_facet	Sibidou Yougbaré Chinmaya Mutalik Pei-Feng Chung Dyah Ika Krisnawati Fajar Rinawati Hengky Irawan Heny Kristanto Tsung-Rong Kuo
author_sort	Sibidou Yougbaré
title	Gold Nanorod-Decorated Metallic MoS<sub>2</sub> Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy
title_short	Gold Nanorod-Decorated Metallic MoS<sub>2</sub> Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy
title_full	Gold Nanorod-Decorated Metallic MoS<sub>2</sub> Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy
title_fullStr	Gold Nanorod-Decorated Metallic MoS<sub>2</sub> Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy
title_full_unstemmed	Gold Nanorod-Decorated Metallic MoS<sub>2</sub> Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy
title_sort	gold nanorod-decorated metallic mos<sub>2</sub> nanosheets for synergistic photothermal and photodynamic antibacterial therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/932b06cf44a54320aa18cc1bc3631402
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Gold Nanorod-Decorated Metallic MoS<sub>2</sub> Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy

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