Expression of chemerin correlates with a poor prognosis in female breast cancer patients

Ghada El-Sagheer,1 Mariana Gayyed,2 Asmaa Ahmad,1 Aliaa Abd El-Fattah,3 Manar Mohamed4 1Endocrinology Unit, Department of Internal Medicine, Minia Faculty of Medicine, Minia University, Minia, Egypt; 2Department of Pathology, Minia Faculty of Medicine, Minia University, Minia, Egypt; 3Department of...

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Autores principales:	El-Sagheer G, Gayyed M, Ahmad A, Abd El-Fatah A, Mohamed M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	chemerin expression breast cancer adipocyte development obesity. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/932c9aa9bda34255a3a7e4658495d33c
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spelling	oai:doaj.org-article:932c9aa9bda34255a3a7e4658495d33c2021-12-02T07:42:22ZExpression of chemerin correlates with a poor prognosis in female breast cancer patients1179-1314https://doaj.org/article/932c9aa9bda34255a3a7e4658495d33c2018-10-01T00:00:00Zhttps://www.dovepress.com/expression-of-chemerin-correlates-with-a-poor-prognosis-in-female-brea-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Ghada El-Sagheer,1 Mariana Gayyed,2 Asmaa Ahmad,1 Aliaa Abd El-Fattah,3 Manar Mohamed4 1Endocrinology Unit, Department of Internal Medicine, Minia Faculty of Medicine, Minia University, Minia, Egypt; 2Department of Pathology, Minia Faculty of Medicine, Minia University, Minia, Egypt; 3Department of Internal Medicine, Minia Faculty of Medicine, Minia University, Minia, Egypt; 4Department of Internal Medicine, Deraya University, Minia, Egypt Objective: Chemerin was reported to regulate adipogenesis, metabolism, and immunity. But, its relation to cancer remains controversial. In breast cancer, chemerin expression has only been studied in serum, however, its expression in tissue, to our knowledge, has not been studied. The aim of this study was to investigate chemerin expression in breast cancer tissue in comparison to the adjacent normal tissue, and to assess its relationship to disease prognosis. Methods: We examined chemerin expression in tissue with immunohistochemistry and analyzed the association of chemerin expression with the patients’ clinical and pathological characteristics to determine its role as a predictor of the disease and its relation to disease prognosis. Results: We detected a significantly higher expression of chemerin in the malignant vs the non-cancerous tissue specimens in 30/53, (56%) patients, (P=0.001). Moreover, its expression was significantly higher in the metastatic lymph nodes in comparison to the tumor tissues, (P=0.01). Chemerin expression was significantly correlated with weight (r=0.256, P=0.04), body mass index (r=0.233, P=0.03), tumor size (r=0.235, P=0.03), lymph node metastasis (r=0.265, P=0.045), distant metastasis (r=0.267, P=0.02), and tumor grading, (r=0.421, P=0.004), while it was inversely significantly correlated with estrogen receptor and progesterone receptor expression in malignant breast tissues (P=0.038, r=-0.437, and P=0.047, r=–0.316), respectively. The area under the receiver operating characteristic curve for chemerin as a predictor of breast cancer was 0.82, (P<0.001, sensitivity 89%, and specificity 69%). The Kaplan–Meier survival curves revealed that patients with higher chemerin expression had worse overall survival in comparison to those with a lower chemerin expression, (P=0.001). Conclusion: Our results revealed higher chemerin expression in malignant vs adjacent normal breast tissue and lend support to a presumable role of chemerin tissue expression as an independent predictor of poor prognosis in breast cancer patients. Keywords: chemerin expression, breast cancer, adipocyte development, obesityEl-Sagheer GGayyed MAhmad AAbd El-Fatah AMohamed MDove Medical Pressarticlechemerin expressionbreast canceradipocyte developmentobesity.Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 10, Pp 169-176 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	chemerin expression breast cancer adipocyte development obesity. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	chemerin expression breast cancer adipocyte development obesity. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 El-Sagheer G Gayyed M Ahmad A Abd El-Fatah A Mohamed M Expression of chemerin correlates with a poor prognosis in female breast cancer patients
description	Ghada El-Sagheer,1 Mariana Gayyed,2 Asmaa Ahmad,1 Aliaa Abd El-Fattah,3 Manar Mohamed4 1Endocrinology Unit, Department of Internal Medicine, Minia Faculty of Medicine, Minia University, Minia, Egypt; 2Department of Pathology, Minia Faculty of Medicine, Minia University, Minia, Egypt; 3Department of Internal Medicine, Minia Faculty of Medicine, Minia University, Minia, Egypt; 4Department of Internal Medicine, Deraya University, Minia, Egypt Objective: Chemerin was reported to regulate adipogenesis, metabolism, and immunity. But, its relation to cancer remains controversial. In breast cancer, chemerin expression has only been studied in serum, however, its expression in tissue, to our knowledge, has not been studied. The aim of this study was to investigate chemerin expression in breast cancer tissue in comparison to the adjacent normal tissue, and to assess its relationship to disease prognosis. Methods: We examined chemerin expression in tissue with immunohistochemistry and analyzed the association of chemerin expression with the patients’ clinical and pathological characteristics to determine its role as a predictor of the disease and its relation to disease prognosis. Results: We detected a significantly higher expression of chemerin in the malignant vs the non-cancerous tissue specimens in 30/53, (56%) patients, (P=0.001). Moreover, its expression was significantly higher in the metastatic lymph nodes in comparison to the tumor tissues, (P=0.01). Chemerin expression was significantly correlated with weight (r=0.256, P=0.04), body mass index (r=0.233, P=0.03), tumor size (r=0.235, P=0.03), lymph node metastasis (r=0.265, P=0.045), distant metastasis (r=0.267, P=0.02), and tumor grading, (r=0.421, P=0.004), while it was inversely significantly correlated with estrogen receptor and progesterone receptor expression in malignant breast tissues (P=0.038, r=-0.437, and P=0.047, r=–0.316), respectively. The area under the receiver operating characteristic curve for chemerin as a predictor of breast cancer was 0.82, (P<0.001, sensitivity 89%, and specificity 69%). The Kaplan–Meier survival curves revealed that patients with higher chemerin expression had worse overall survival in comparison to those with a lower chemerin expression, (P=0.001). Conclusion: Our results revealed higher chemerin expression in malignant vs adjacent normal breast tissue and lend support to a presumable role of chemerin tissue expression as an independent predictor of poor prognosis in breast cancer patients. Keywords: chemerin expression, breast cancer, adipocyte development, obesity
format	article
author	El-Sagheer G Gayyed M Ahmad A Abd El-Fatah A Mohamed M
author_facet	El-Sagheer G Gayyed M Ahmad A Abd El-Fatah A Mohamed M
author_sort	El-Sagheer G
title	Expression of chemerin correlates with a poor prognosis in female breast cancer patients
title_short	Expression of chemerin correlates with a poor prognosis in female breast cancer patients
title_full	Expression of chemerin correlates with a poor prognosis in female breast cancer patients
title_fullStr	Expression of chemerin correlates with a poor prognosis in female breast cancer patients
title_full_unstemmed	Expression of chemerin correlates with a poor prognosis in female breast cancer patients
title_sort	expression of chemerin correlates with a poor prognosis in female breast cancer patients
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/932c9aa9bda34255a3a7e4658495d33c
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Expression of chemerin correlates with a poor prognosis in female breast cancer patients

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