Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering

Collagen type II is the major constituent of cartilage tissue. Yet, cartilage engineering approaches are primarily based on collagen type I devices that are associated with suboptimal functional therapeutic outcomes. Herein, we briefly describe cartilage's development and cellular and extracell...

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Autores principales:	Z Wu, SH Korntner, AM Mullen, DI Zeugolis
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Collagen type II Articular cartilage Chondrocytes Chondrogenic induction Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/932d115fc1ce4b2c96302b452e7dc7c0
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spelling	oai:doaj.org-article:932d115fc1ce4b2c96302b452e7dc7c02021-11-30T04:17:43ZCollagen type II: From biosynthesis to advanced biomaterials for cartilage engineering2666-534410.1016/j.bbiosy.2021.100030https://doaj.org/article/932d115fc1ce4b2c96302b452e7dc7c02021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666534421000234https://doaj.org/toc/2666-5344Collagen type II is the major constituent of cartilage tissue. Yet, cartilage engineering approaches are primarily based on collagen type I devices that are associated with suboptimal functional therapeutic outcomes. Herein, we briefly describe cartilage's development and cellular and extracellular composition and organisation. We also provide an overview of collagen type II biosynthesis and purification protocols from tissues of terrestrial and marine species and recombinant systems. We then advocate the use of collagen type II as a building block in cartilage engineering approaches, based on safety, efficiency and efficacy data that have been derived over the years from numerous in vitro and in vivo studies.Z WuSH KorntnerAM MullenDI ZeugolisElsevierarticleCollagen type IIArticular cartilageChondrocytesChondrogenic inductionMedical technologyR855-855.5ENBiomaterials and Biosystems, Vol 4, Iss , Pp 100030- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Collagen type II Articular cartilage Chondrocytes Chondrogenic induction Medical technology R855-855.5
spellingShingle	Collagen type II Articular cartilage Chondrocytes Chondrogenic induction Medical technology R855-855.5 Z Wu SH Korntner AM Mullen DI Zeugolis Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering
description	Collagen type II is the major constituent of cartilage tissue. Yet, cartilage engineering approaches are primarily based on collagen type I devices that are associated with suboptimal functional therapeutic outcomes. Herein, we briefly describe cartilage's development and cellular and extracellular composition and organisation. We also provide an overview of collagen type II biosynthesis and purification protocols from tissues of terrestrial and marine species and recombinant systems. We then advocate the use of collagen type II as a building block in cartilage engineering approaches, based on safety, efficiency and efficacy data that have been derived over the years from numerous in vitro and in vivo studies.
format	article
author	Z Wu SH Korntner AM Mullen DI Zeugolis
author_facet	Z Wu SH Korntner AM Mullen DI Zeugolis
author_sort	Z Wu
title	Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering
title_short	Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering
title_full	Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering
title_fullStr	Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering
title_full_unstemmed	Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering
title_sort	collagen type ii: from biosynthesis to advanced biomaterials for cartilage engineering
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/932d115fc1ce4b2c96302b452e7dc7c0
work_keys_str_mv	AT zwu collagentypeiifrombiosynthesistoadvancedbiomaterialsforcartilageengineering AT shkorntner collagentypeiifrombiosynthesistoadvancedbiomaterialsforcartilageengineering AT ammullen collagentypeiifrombiosynthesistoadvancedbiomaterialsforcartilageengineering AT dizeugolis collagentypeiifrombiosynthesistoadvancedbiomaterialsforcartilageengineering
_version_	1718406763573673984

Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering

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