Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect

Abstract Methods to repair bone defects arising from trauma, resection, or disease, continue to be sought after. Cyclic mechanical loading is well established to influence bone (re)modelling activity, in which bone formation and resorption are correlated to micro-scale strain. Based on this, the app...

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Autores principales:	Angad Malhotra, Matthias Walle, Graeme R. Paul, Gisela A. Kuhn, Ralph Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/932dc12db2db45f8ae3fdcce2385b2d8
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spelling	oai:doaj.org-article:932dc12db2db45f8ae3fdcce2385b2d82021-12-02T10:49:16ZApplication of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect10.1038/s41598-021-81132-82045-2322https://doaj.org/article/932dc12db2db45f8ae3fdcce2385b2d82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81132-8https://doaj.org/toc/2045-2322Abstract Methods to repair bone defects arising from trauma, resection, or disease, continue to be sought after. Cyclic mechanical loading is well established to influence bone (re)modelling activity, in which bone formation and resorption are correlated to micro-scale strain. Based on this, the application of mechanical stimulation across a bone defect could improve healing. However, if ignoring the mechanical integrity of defected bone, loading regimes have a high potential to either cause damage or be ineffective. This study explores real-time finite element (rtFE) methods that use three-dimensional structural analyses from micro-computed tomography images to estimate effective peak cyclic loads in a subject-specific and time-dependent manner. It demonstrates the concept in a cyclically loaded mouse caudal vertebral bone defect model. Using rtFE analysis combined with adaptive mechanical loading, mouse bone healing was significantly improved over non-loaded controls, with no incidence of vertebral fractures. Such rtFE-driven adaptive loading regimes demonstrated here could be relevant to clinical bone defect healing scenarios, where mechanical loading can become patient-specific and more efficacious. This is achieved by accounting for initial bone defect conditions and spatio-temporal healing, both being factors that are always unique to the patient.Angad MalhotraMatthias WalleGraeme R. PaulGisela A. KuhnRalph MüllerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angad Malhotra Matthias Walle Graeme R. Paul Gisela A. Kuhn Ralph Müller Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect
description	Abstract Methods to repair bone defects arising from trauma, resection, or disease, continue to be sought after. Cyclic mechanical loading is well established to influence bone (re)modelling activity, in which bone formation and resorption are correlated to micro-scale strain. Based on this, the application of mechanical stimulation across a bone defect could improve healing. However, if ignoring the mechanical integrity of defected bone, loading regimes have a high potential to either cause damage or be ineffective. This study explores real-time finite element (rtFE) methods that use three-dimensional structural analyses from micro-computed tomography images to estimate effective peak cyclic loads in a subject-specific and time-dependent manner. It demonstrates the concept in a cyclically loaded mouse caudal vertebral bone defect model. Using rtFE analysis combined with adaptive mechanical loading, mouse bone healing was significantly improved over non-loaded controls, with no incidence of vertebral fractures. Such rtFE-driven adaptive loading regimes demonstrated here could be relevant to clinical bone defect healing scenarios, where mechanical loading can become patient-specific and more efficacious. This is achieved by accounting for initial bone defect conditions and spatio-temporal healing, both being factors that are always unique to the patient.
format	article
author	Angad Malhotra Matthias Walle Graeme R. Paul Gisela A. Kuhn Ralph Müller
author_facet	Angad Malhotra Matthias Walle Graeme R. Paul Gisela A. Kuhn Ralph Müller
author_sort	Angad Malhotra
title	Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect
title_short	Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect
title_full	Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect
title_fullStr	Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect
title_full_unstemmed	Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect
title_sort	application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/932dc12db2db45f8ae3fdcce2385b2d8
work_keys_str_mv	AT angadmalhotra applicationofsubjectspecificadaptivemechanicalloadingforbonehealinginamousetailvertebraldefect AT matthiaswalle applicationofsubjectspecificadaptivemechanicalloadingforbonehealinginamousetailvertebraldefect AT graemerpaul applicationofsubjectspecificadaptivemechanicalloadingforbonehealinginamousetailvertebraldefect AT giselaakuhn applicationofsubjectspecificadaptivemechanicalloadingforbonehealinginamousetailvertebraldefect AT ralphmuller applicationofsubjectspecificadaptivemechanicalloadingforbonehealinginamousetailvertebraldefect
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Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect

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