Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease
Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within t...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:932ec238dd0f45d79f5c4262de1f57292021-11-11T17:15:05ZThoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease1664-042X10.3389/fphys.2021.746300https://doaj.org/article/932ec238dd0f45d79f5c4262de1f57292021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.746300/fullhttps://doaj.org/toc/1664-042XHere we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model’s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software.Elena KutumovaElena KutumovaElena KutumovaIlya KiselevIlya KiselevIlya KiselevRuslan SharipovRuslan SharipovRuslan SharipovRuslan SharipovGalina LifshitsFedor KolpakovFedor KolpakovFedor KolpakovFrontiers Media S.A.articlemathematical modelingagent-based modelmodular modelcardiovascular systemrenal systemblood pressure regulationPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
mathematical modeling agent-based model modular model cardiovascular system renal system blood pressure regulation Physiology QP1-981 |
| spellingShingle |
mathematical modeling agent-based model modular model cardiovascular system renal system blood pressure regulation Physiology QP1-981 Elena Kutumova Elena Kutumova Elena Kutumova Ilya Kiselev Ilya Kiselev Ilya Kiselev Ruslan Sharipov Ruslan Sharipov Ruslan Sharipov Ruslan Sharipov Galina Lifshits Fedor Kolpakov Fedor Kolpakov Fedor Kolpakov Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease |
| description |
Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model’s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software. |
| format |
article |
| author |
Elena Kutumova Elena Kutumova Elena Kutumova Ilya Kiselev Ilya Kiselev Ilya Kiselev Ruslan Sharipov Ruslan Sharipov Ruslan Sharipov Ruslan Sharipov Galina Lifshits Fedor Kolpakov Fedor Kolpakov Fedor Kolpakov |
| author_facet |
Elena Kutumova Elena Kutumova Elena Kutumova Ilya Kiselev Ilya Kiselev Ilya Kiselev Ruslan Sharipov Ruslan Sharipov Ruslan Sharipov Ruslan Sharipov Galina Lifshits Fedor Kolpakov Fedor Kolpakov Fedor Kolpakov |
| author_sort |
Elena Kutumova |
| title |
Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease |
| title_short |
Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease |
| title_full |
Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease |
| title_fullStr |
Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease |
| title_full_unstemmed |
Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease |
| title_sort |
thoroughly calibrated modular agent-based model of the human cardiovascular and renal systems for blood pressure regulation in health and disease |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/932ec238dd0f45d79f5c4262de1f5729 |
| work_keys_str_mv |
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