The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid

The human ATP-binding cassette transporter ABCG2 plays critical roles in anticancer resistance but the molecular mechanism of ABCG2-mediated substrate transport remains enigmatic. Here authors use extensive mutagenesis and molecular dynamics simulations to reveal a mechanistic basis for the function...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Narakorn Khunweeraphong, Daniel Szöllősi, Thomas Stockner, Karl Kuchler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/932f6881bada41a88b88c2dc83c6dbcd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:932f6881bada41a88b88c2dc83c6dbcd
record_format	dspace
spelling	oai:doaj.org-article:932f6881bada41a88b88c2dc83c6dbcd2021-12-02T17:01:39ZThe ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid10.1038/s41467-019-13302-22041-1723https://doaj.org/article/932f6881bada41a88b88c2dc83c6dbcd2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13302-2https://doaj.org/toc/2041-1723The human ATP-binding cassette transporter ABCG2 plays critical roles in anticancer resistance but the molecular mechanism of ABCG2-mediated substrate transport remains enigmatic. Here authors use extensive mutagenesis and molecular dynamics simulations to reveal a mechanistic basis for the function of the di-leucine valve and the roof organization in the transport cycle.Narakorn KhunweeraphongDaniel SzöllősiThomas StocknerKarl KuchlerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Narakorn Khunweeraphong Daniel Szöllősi Thomas Stockner Karl Kuchler The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid
description	The human ATP-binding cassette transporter ABCG2 plays critical roles in anticancer resistance but the molecular mechanism of ABCG2-mediated substrate transport remains enigmatic. Here authors use extensive mutagenesis and molecular dynamics simulations to reveal a mechanistic basis for the function of the di-leucine valve and the roof organization in the transport cycle.
format	article
author	Narakorn Khunweeraphong Daniel Szöllősi Thomas Stockner Karl Kuchler
author_facet	Narakorn Khunweeraphong Daniel Szöllősi Thomas Stockner Karl Kuchler
author_sort	Narakorn Khunweeraphong
title	The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid
title_short	The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid
title_full	The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid
title_fullStr	The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid
title_full_unstemmed	The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid
title_sort	abcg2 multidrug transporter is a pump gated by a valve and an extracellular lid
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/932f6881bada41a88b88c2dc83c6dbcd
work_keys_str_mv	AT narakornkhunweeraphong theabcg2multidrugtransporterisapumpgatedbyavalveandanextracellularlid AT danielszollosi theabcg2multidrugtransporterisapumpgatedbyavalveandanextracellularlid AT thomasstockner theabcg2multidrugtransporterisapumpgatedbyavalveandanextracellularlid AT karlkuchler theabcg2multidrugtransporterisapumpgatedbyavalveandanextracellularlid AT narakornkhunweeraphong abcg2multidrugtransporterisapumpgatedbyavalveandanextracellularlid AT danielszollosi abcg2multidrugtransporterisapumpgatedbyavalveandanextracellularlid AT thomasstockner abcg2multidrugtransporterisapumpgatedbyavalveandanextracellularlid AT karlkuchler abcg2multidrugtransporterisapumpgatedbyavalveandanextracellularlid
_version_	1718382096816275456

The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid

Ejemplares similares