Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study

Qi Liu,1 Xiaoling Liao,1 Yuesong Pan,2 Aoming Jin,2 Yumei Zhang3 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, Peo...

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Autores principales:	Liu Q, Liao X, Pan Y, Jin A, Zhang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	uric acid cognitive impairment stroke transient ischemic attack u-shaped curve Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/93393db5219c44189e598373f7d34bdb
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spelling	oai:doaj.org-article:93393db5219c44189e598373f7d34bdb2021-12-02T18:13:44ZAssociation Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study1178-2021https://doaj.org/article/93393db5219c44189e598373f7d34bdb2021-03-01T00:00:00Zhttps://www.dovepress.com/association-between-serum-uric-acid-levels-and-cognitive-function-in-p-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Qi Liu,1 Xiaoling Liao,1 Yuesong Pan,2 Aoming Jin,2 Yumei Zhang3 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, People’s Republic of China; 3Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Yumei ZhangDepartment of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, 119#Nan Si Huan Xi Lu, Beijing, 100070, People’s Republic of ChinaTel +86 136-9140-4106Email zhangyumei95@aliyun.comPurpose: Cognitive impairment is a common complication after stroke and transient ischemic attack (TIA). The relationship between serum uric acid (SUA) and post-stroke cognitive impairment (PSCI) is controversial. This study evaluated the association of different SUA levels in the normal range and PSCI at 3 months.Patients and Methods: A total of 1523 patients with ischemic stroke/TIA were recruited from the Impairment of Cognition and Sleep (ICONS) subgroup of the China National Stroke Registry-3 (CNSR-3). SUA concentration was assessed at baseline. Global cognitive status was evaluated using the Montreal Cognitive Assessment (MoCA). The main clinical outcome was the incidence of PSCI assessed at 3 months after stroke/TIA. The association between SUA status and the risk of PSCI was assessed with multiple regression models adjusted for potential covariates.Results: Among the 1523 patients (1391 (91.33%) stroke patients and 132 (8.67%) TIA patients), 747 (49.05%) patients had PSCI at 3 months. Compared to the reference group, there was an increased risk of PSCI in males with SUA levels in the first (OR=1.76) and fourth quartiles (OR=1.47). A U-shaped association between SUA levels and the incidence of PSCI with an inflection point of 297 mmol/L was also found in males. However, there was no association between SUA levels and PSCI in females.Conclusion: The association between SUA and PSCI differed between males and females. In males, both low and high SUA levels were associated with relatively higher incidences of PSCI, supporting a U-shaped association between SUA levels and PSCI.Keywords: uric acid, cognitive impairment, stroke, transient ischemic attack, U-shaped curveLiu QLiao XPan YJin AZhang YDove Medical Pressarticleuric acidcognitive impairmentstroketransient ischemic attacku-shaped curveNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 991-999 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	uric acid cognitive impairment stroke transient ischemic attack u-shaped curve Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	uric acid cognitive impairment stroke transient ischemic attack u-shaped curve Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Liu Q Liao X Pan Y Jin A Zhang Y Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study
description	Qi Liu,1 Xiaoling Liao,1 Yuesong Pan,2 Aoming Jin,2 Yumei Zhang3 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, People’s Republic of China; 3Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Yumei ZhangDepartment of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, 119#Nan Si Huan Xi Lu, Beijing, 100070, People’s Republic of ChinaTel +86 136-9140-4106Email zhangyumei95@aliyun.comPurpose: Cognitive impairment is a common complication after stroke and transient ischemic attack (TIA). The relationship between serum uric acid (SUA) and post-stroke cognitive impairment (PSCI) is controversial. This study evaluated the association of different SUA levels in the normal range and PSCI at 3 months.Patients and Methods: A total of 1523 patients with ischemic stroke/TIA were recruited from the Impairment of Cognition and Sleep (ICONS) subgroup of the China National Stroke Registry-3 (CNSR-3). SUA concentration was assessed at baseline. Global cognitive status was evaluated using the Montreal Cognitive Assessment (MoCA). The main clinical outcome was the incidence of PSCI assessed at 3 months after stroke/TIA. The association between SUA status and the risk of PSCI was assessed with multiple regression models adjusted for potential covariates.Results: Among the 1523 patients (1391 (91.33%) stroke patients and 132 (8.67%) TIA patients), 747 (49.05%) patients had PSCI at 3 months. Compared to the reference group, there was an increased risk of PSCI in males with SUA levels in the first (OR=1.76) and fourth quartiles (OR=1.47). A U-shaped association between SUA levels and the incidence of PSCI with an inflection point of 297 mmol/L was also found in males. However, there was no association between SUA levels and PSCI in females.Conclusion: The association between SUA and PSCI differed between males and females. In males, both low and high SUA levels were associated with relatively higher incidences of PSCI, supporting a U-shaped association between SUA levels and PSCI.Keywords: uric acid, cognitive impairment, stroke, transient ischemic attack, U-shaped curve
format	article
author	Liu Q Liao X Pan Y Jin A Zhang Y
author_facet	Liu Q Liao X Pan Y Jin A Zhang Y
author_sort	Liu Q
title	Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study
title_short	Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study
title_full	Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study
title_fullStr	Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study
title_full_unstemmed	Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study
title_sort	association between serum uric acid levels and cognitive function in patients with ischemic stroke and transient ischemic attack (tia): a 3-month follow-up study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/93393db5219c44189e598373f7d34bdb
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Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study

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