Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen.

The article expands our knowledge on the variety of biodegraders of ibuprofen, one of the most frequently detected non-steroidal anti-inflammatory drugs in the environment. We studied the dynamics of ibuprofen decomposition and its relationship with the physiological status of bacteria and with addi...

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Autores principales:	Irina B Ivshina, Elena A Tyumina, Grigory A Bazhutin, Elena V Vikhareva
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/93399ad52bb6465bbfab604644e8ef57
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spelling	oai:doaj.org-article:93399ad52bb6465bbfab604644e8ef572021-12-02T20:12:45ZResponse of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen.1932-620310.1371/journal.pone.0260032https://doaj.org/article/93399ad52bb6465bbfab604644e8ef572021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260032https://doaj.org/toc/1932-6203The article expands our knowledge on the variety of biodegraders of ibuprofen, one of the most frequently detected non-steroidal anti-inflammatory drugs in the environment. We studied the dynamics of ibuprofen decomposition and its relationship with the physiological status of bacteria and with additional carbon and energy sources. The involvement of cytoplasmic enzymes in ibuprofen biodegradation was confirmed. Within the tested actinobacteria, Rhodococcus cerastii IEGM 1278 was capable of complete oxidation of 100 μg/L and 100 mg/L of ibuprofen in 30 h and 144 h, respectively, in the presence of an alternative carbon source (n-hexadecane). Besides, the presence of ibuprofen induced a transition of rhodococci from single- to multicellular lifeforms, a shift to more negative zeta potential values, and a decrease in the membrane permeability. The initial steps of ibuprofen biotransformation by R. cerastii IEGM 1278 involved the formation of hydroxylated and decarboxylated derivatives with higher phytotoxicity than the parent compound (ibuprofen). The data obtained indicate potential threats of this pharmaceutical pollutant and its metabolites to biota and natural ecosystems.Irina B IvshinaElena A TyuminaGrigory A BazhutinElena V VikharevaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260032 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Irina B Ivshina Elena A Tyumina Grigory A Bazhutin Elena V Vikhareva Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen.
description	The article expands our knowledge on the variety of biodegraders of ibuprofen, one of the most frequently detected non-steroidal anti-inflammatory drugs in the environment. We studied the dynamics of ibuprofen decomposition and its relationship with the physiological status of bacteria and with additional carbon and energy sources. The involvement of cytoplasmic enzymes in ibuprofen biodegradation was confirmed. Within the tested actinobacteria, Rhodococcus cerastii IEGM 1278 was capable of complete oxidation of 100 μg/L and 100 mg/L of ibuprofen in 30 h and 144 h, respectively, in the presence of an alternative carbon source (n-hexadecane). Besides, the presence of ibuprofen induced a transition of rhodococci from single- to multicellular lifeforms, a shift to more negative zeta potential values, and a decrease in the membrane permeability. The initial steps of ibuprofen biotransformation by R. cerastii IEGM 1278 involved the formation of hydroxylated and decarboxylated derivatives with higher phytotoxicity than the parent compound (ibuprofen). The data obtained indicate potential threats of this pharmaceutical pollutant and its metabolites to biota and natural ecosystems.
format	article
author	Irina B Ivshina Elena A Tyumina Grigory A Bazhutin Elena V Vikhareva
author_facet	Irina B Ivshina Elena A Tyumina Grigory A Bazhutin Elena V Vikhareva
author_sort	Irina B Ivshina
title	Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen.
title_short	Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen.
title_full	Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen.
title_fullStr	Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen.
title_full_unstemmed	Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen.
title_sort	response of rhodococcus cerastii iegm 1278 to toxic effects of ibuprofen.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/93399ad52bb6465bbfab604644e8ef57
work_keys_str_mv	AT irinabivshina responseofrhodococcuscerastiiiegm1278totoxiceffectsofibuprofen AT elenaatyumina responseofrhodococcuscerastiiiegm1278totoxiceffectsofibuprofen AT grigoryabazhutin responseofrhodococcuscerastiiiegm1278totoxiceffectsofibuprofen AT elenavvikhareva responseofrhodococcuscerastiiiegm1278totoxiceffectsofibuprofen
_version_	1718374838262824960

Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen.

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