Long days enhance recognition memory and increase insulin-like growth factor 2 in the hippocampus

Abstract Light improves cognitive function in humans; however, the neurobiological mechanisms underlying positive effects of light remain unclear. One obstacle is that most rodent models have employed lighting conditions that cause cognitive deficits rather than improvements. Here we have developed...

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Autores principales:	Adriano Dellapolla, Ian Kloehn, Harshida Pancholi, Ben Callif, David Wertz, Kayla E. Rohr, Matthew M. Hurley, Kimberly M. Baker, Samer Hattar, Marieke R. Gilmartin, Jennifer A. Evans
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/933aa58583174768b0ff8c9ff02dcc4b
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spelling	oai:doaj.org-article:933aa58583174768b0ff8c9ff02dcc4b2021-12-02T15:05:01ZLong days enhance recognition memory and increase insulin-like growth factor 2 in the hippocampus10.1038/s41598-017-03896-22045-2322https://doaj.org/article/933aa58583174768b0ff8c9ff02dcc4b2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03896-2https://doaj.org/toc/2045-2322Abstract Light improves cognitive function in humans; however, the neurobiological mechanisms underlying positive effects of light remain unclear. One obstacle is that most rodent models have employed lighting conditions that cause cognitive deficits rather than improvements. Here we have developed a mouse model where light improves cognitive function, which provides insight into mechanisms underlying positive effects of light. To increase light exposure without eliminating daily rhythms, we exposed mice to either a standard photoperiod or a long day photoperiod. Long days enhanced long-term recognition memory, and this effect was abolished by loss of the photopigment melanopsin. Further, long days markedly altered hippocampal clock function and elevated transcription of Insulin-like Growth Factor2 (Igf2). Up-regulation of Igf2 occurred in tandem with suppression of its transcriptional repressor Wilm’s tumor1. Consistent with molecular de-repression of Igf2, IGF2 expression was increased in the hippocampus before and after memory training. Lastly, long days occluded IGF2-induced improvements in recognition memory. Collectively, these results suggest that light changes hippocampal clock function to alter memory, highlighting novel mechanisms that may contribute to the positive effects of light. Furthermore, this study provides insight into how the circadian clock can regulate hippocampus-dependent learning by controlling molecular processes required for memory consolidation.Adriano DellapollaIan KloehnHarshida PancholiBen CallifDavid WertzKayla E. RohrMatthew M. HurleyKimberly M. BakerSamer HattarMarieke R. GilmartinJennifer A. EvansNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adriano Dellapolla Ian Kloehn Harshida Pancholi Ben Callif David Wertz Kayla E. Rohr Matthew M. Hurley Kimberly M. Baker Samer Hattar Marieke R. Gilmartin Jennifer A. Evans Long days enhance recognition memory and increase insulin-like growth factor 2 in the hippocampus
description	Abstract Light improves cognitive function in humans; however, the neurobiological mechanisms underlying positive effects of light remain unclear. One obstacle is that most rodent models have employed lighting conditions that cause cognitive deficits rather than improvements. Here we have developed a mouse model where light improves cognitive function, which provides insight into mechanisms underlying positive effects of light. To increase light exposure without eliminating daily rhythms, we exposed mice to either a standard photoperiod or a long day photoperiod. Long days enhanced long-term recognition memory, and this effect was abolished by loss of the photopigment melanopsin. Further, long days markedly altered hippocampal clock function and elevated transcription of Insulin-like Growth Factor2 (Igf2). Up-regulation of Igf2 occurred in tandem with suppression of its transcriptional repressor Wilm’s tumor1. Consistent with molecular de-repression of Igf2, IGF2 expression was increased in the hippocampus before and after memory training. Lastly, long days occluded IGF2-induced improvements in recognition memory. Collectively, these results suggest that light changes hippocampal clock function to alter memory, highlighting novel mechanisms that may contribute to the positive effects of light. Furthermore, this study provides insight into how the circadian clock can regulate hippocampus-dependent learning by controlling molecular processes required for memory consolidation.
format	article
author	Adriano Dellapolla Ian Kloehn Harshida Pancholi Ben Callif David Wertz Kayla E. Rohr Matthew M. Hurley Kimberly M. Baker Samer Hattar Marieke R. Gilmartin Jennifer A. Evans
author_facet	Adriano Dellapolla Ian Kloehn Harshida Pancholi Ben Callif David Wertz Kayla E. Rohr Matthew M. Hurley Kimberly M. Baker Samer Hattar Marieke R. Gilmartin Jennifer A. Evans
author_sort	Adriano Dellapolla
title	Long days enhance recognition memory and increase insulin-like growth factor 2 in the hippocampus
title_short	Long days enhance recognition memory and increase insulin-like growth factor 2 in the hippocampus
title_full	Long days enhance recognition memory and increase insulin-like growth factor 2 in the hippocampus
title_fullStr	Long days enhance recognition memory and increase insulin-like growth factor 2 in the hippocampus
title_full_unstemmed	Long days enhance recognition memory and increase insulin-like growth factor 2 in the hippocampus
title_sort	long days enhance recognition memory and increase insulin-like growth factor 2 in the hippocampus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/933aa58583174768b0ff8c9ff02dcc4b
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Long days enhance recognition memory and increase insulin-like growth factor 2 in the hippocampus

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