Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles

Nicotinic acid adenine dinucleotide phosphate (NAADP) potent Ca2+ mobilizing second messenger which uniquely triggers Ca2+ release from acidic endolysosomal organelles. Here the authors identify Lsm12 as an NAADP receptor essential for NAADP-evoked Ca2+ release from lysosomes via NAADP binding on it...

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Autores principales:	Jiyuan Zhang, Xin Guan, Kunal Shah, Jiusheng Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/933aee33b6654e7dbfbaeeb79e0039d0
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spelling	oai:doaj.org-article:933aee33b6654e7dbfbaeeb79e0039d02021-12-02T16:35:42ZLsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles10.1038/s41467-021-24735-z2041-1723https://doaj.org/article/933aee33b6654e7dbfbaeeb79e0039d02021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24735-zhttps://doaj.org/toc/2041-1723Nicotinic acid adenine dinucleotide phosphate (NAADP) potent Ca2+ mobilizing second messenger which uniquely triggers Ca2+ release from acidic endolysosomal organelles. Here the authors identify Lsm12 as an NAADP receptor essential for NAADP-evoked Ca2+ release from lysosomes via NAADP binding on its Lsm domain.Jiyuan ZhangXin GuanKunal ShahJiusheng YanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiyuan Zhang Xin Guan Kunal Shah Jiusheng Yan Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles
description	Nicotinic acid adenine dinucleotide phosphate (NAADP) potent Ca2+ mobilizing second messenger which uniquely triggers Ca2+ release from acidic endolysosomal organelles. Here the authors identify Lsm12 as an NAADP receptor essential for NAADP-evoked Ca2+ release from lysosomes via NAADP binding on its Lsm domain.
format	article
author	Jiyuan Zhang Xin Guan Kunal Shah Jiusheng Yan
author_facet	Jiyuan Zhang Xin Guan Kunal Shah Jiusheng Yan
author_sort	Jiyuan Zhang
title	Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles
title_short	Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles
title_full	Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles
title_fullStr	Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles
title_full_unstemmed	Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles
title_sort	lsm12 is an naadp receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/933aee33b6654e7dbfbaeeb79e0039d0
work_keys_str_mv	AT jiyuanzhang lsm12isannaadpreceptorandatwoporechannelregulatoryproteinrequiredforcalciummobilizationfromacidicorganelles AT xinguan lsm12isannaadpreceptorandatwoporechannelregulatoryproteinrequiredforcalciummobilizationfromacidicorganelles AT kunalshah lsm12isannaadpreceptorandatwoporechannelregulatoryproteinrequiredforcalciummobilizationfromacidicorganelles AT jiushengyan lsm12isannaadpreceptorandatwoporechannelregulatoryproteinrequiredforcalciummobilizationfromacidicorganelles
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Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles

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