Non-cancer disease prevalence and association with occupational radiation exposure among Korean radiation workers

Abstract Radiation-induced cancer risks have known stochastic effects; however, regarding non-cancer diseases, evidence of risk at low radiation doses remains unclear. We aimed to identify underlying characteristics concerning non-cancer disease prevalence and determine associations with radiation d...

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Autores principales:	Soojin Park, Dal Nim Lee, Young Woo Jin, Eun Shil Cha, Won-Il Jang, Sunhoo Park, Songwon Seo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/933af31374e84625998377043726b6b5
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spelling	oai:doaj.org-article:933af31374e84625998377043726b6b52021-11-21T12:24:35ZNon-cancer disease prevalence and association with occupational radiation exposure among Korean radiation workers10.1038/s41598-021-01875-22045-2322https://doaj.org/article/933af31374e84625998377043726b6b52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01875-2https://doaj.org/toc/2045-2322Abstract Radiation-induced cancer risks have known stochastic effects; however, regarding non-cancer diseases, evidence of risk at low radiation doses remains unclear. We aimed to identify underlying characteristics concerning non-cancer disease prevalence and determine associations with radiation dose among Korean radiation workers. Using a nationwide baseline survey, 20,608 workers were enrolled. Data concerning participant demographics, occupational characteristics, lifestyle, and lifetime prevalence of non-cancer diseases were linked to a national dose registry. We compared non-cancer disease prevalences in the Korean general population with those in this cohort and undertook a dose–response analysis concerning the cumulative dose. Hyperlipidemia (10.6%), circulatory (9.6%), and respiratory (4.1%) system diseases, followed by thyroid diseases (3.5%), had the highest prevalences, with hyperlipidemia, thyroid diseases, and hepatitis prevalence being higher in the cohort than in the general population. Radiation doses were associated with elevated prevalences of most diseases; however, associations were attenuated and not significant after adjusting for confounders, except for musculoskeletal system diseases (prevalence odds ratio [POR]/10 mSv, 1.03; 95% confidence interval [CI] 1.00–1.07) and cataracts (POR/10 mSv, 1.04; 95% CI 1.00–1.07). Further studies are warranted to investigate the causality of those non-cancer diseases involving more varied confounders such as physical and psychosocial stresses and ultraviolet light.Soojin ParkDal Nim LeeYoung Woo JinEun Shil ChaWon-Il JangSunhoo ParkSongwon SeoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Soojin Park Dal Nim Lee Young Woo Jin Eun Shil Cha Won-Il Jang Sunhoo Park Songwon Seo Non-cancer disease prevalence and association with occupational radiation exposure among Korean radiation workers
description	Abstract Radiation-induced cancer risks have known stochastic effects; however, regarding non-cancer diseases, evidence of risk at low radiation doses remains unclear. We aimed to identify underlying characteristics concerning non-cancer disease prevalence and determine associations with radiation dose among Korean radiation workers. Using a nationwide baseline survey, 20,608 workers were enrolled. Data concerning participant demographics, occupational characteristics, lifestyle, and lifetime prevalence of non-cancer diseases were linked to a national dose registry. We compared non-cancer disease prevalences in the Korean general population with those in this cohort and undertook a dose–response analysis concerning the cumulative dose. Hyperlipidemia (10.6%), circulatory (9.6%), and respiratory (4.1%) system diseases, followed by thyroid diseases (3.5%), had the highest prevalences, with hyperlipidemia, thyroid diseases, and hepatitis prevalence being higher in the cohort than in the general population. Radiation doses were associated with elevated prevalences of most diseases; however, associations were attenuated and not significant after adjusting for confounders, except for musculoskeletal system diseases (prevalence odds ratio [POR]/10 mSv, 1.03; 95% confidence interval [CI] 1.00–1.07) and cataracts (POR/10 mSv, 1.04; 95% CI 1.00–1.07). Further studies are warranted to investigate the causality of those non-cancer diseases involving more varied confounders such as physical and psychosocial stresses and ultraviolet light.
format	article
author	Soojin Park Dal Nim Lee Young Woo Jin Eun Shil Cha Won-Il Jang Sunhoo Park Songwon Seo
author_facet	Soojin Park Dal Nim Lee Young Woo Jin Eun Shil Cha Won-Il Jang Sunhoo Park Songwon Seo
author_sort	Soojin Park
title	Non-cancer disease prevalence and association with occupational radiation exposure among Korean radiation workers
title_short	Non-cancer disease prevalence and association with occupational radiation exposure among Korean radiation workers
title_full	Non-cancer disease prevalence and association with occupational radiation exposure among Korean radiation workers
title_fullStr	Non-cancer disease prevalence and association with occupational radiation exposure among Korean radiation workers
title_full_unstemmed	Non-cancer disease prevalence and association with occupational radiation exposure among Korean radiation workers
title_sort	non-cancer disease prevalence and association with occupational radiation exposure among korean radiation workers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/933af31374e84625998377043726b6b5
work_keys_str_mv	AT soojinpark noncancerdiseaseprevalenceandassociationwithoccupationalradiationexposureamongkoreanradiationworkers AT dalnimlee noncancerdiseaseprevalenceandassociationwithoccupationalradiationexposureamongkoreanradiationworkers AT youngwoojin noncancerdiseaseprevalenceandassociationwithoccupationalradiationexposureamongkoreanradiationworkers AT eunshilcha noncancerdiseaseprevalenceandassociationwithoccupationalradiationexposureamongkoreanradiationworkers AT woniljang noncancerdiseaseprevalenceandassociationwithoccupationalradiationexposureamongkoreanradiationworkers AT sunhoopark noncancerdiseaseprevalenceandassociationwithoccupationalradiationexposureamongkoreanradiationworkers AT songwonseo noncancerdiseaseprevalenceandassociationwithoccupationalradiationexposureamongkoreanradiationworkers
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Non-cancer disease prevalence and association with occupational radiation exposure among Korean radiation workers

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