Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming

Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming

De novo DNA methylation has been associated with T cell exhaustion in cancer immunotherapy. Here the authors show that the pre-treatment of CD19 CAR-T cells with the DNA methyltransferase inhibitor decitabine limits exhaustion and confers enhanced proliferative, effector and memory properties upon a...

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Autores principales: Yao Wang, Chuan Tong, Hanren Dai, Zhiqiang Wu, Xiao Han, Yelei Guo, Deyun Chen, Jianshu Wei, Dongdong Ti, Zongzhi Liu, Qian Mei, Xiang Li, Liang Dong, Jing Nie, Yajing Zhang, Weidong Han
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/933c244786634cf58dfafd51abcccf81
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spelling oai:doaj.org-article:933c244786634cf58dfafd51abcccf812021-12-02T13:51:03ZLow-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming10.1038/s41467-020-20696-x2041-1723https://doaj.org/article/933c244786634cf58dfafd51abcccf812021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20696-xhttps://doaj.org/toc/2041-1723De novo DNA methylation has been associated with T cell exhaustion in cancer immunotherapy. Here the authors show that the pre-treatment of CD19 CAR-T cells with the DNA methyltransferase inhibitor decitabine limits exhaustion and confers enhanced proliferative, effector and memory properties upon antigen exposure, with improved tumor control.Yao WangChuan TongHanren DaiZhiqiang WuXiao HanYelei GuoDeyun ChenJianshu WeiDongdong TiZongzhi LiuQian MeiXiang LiLiang DongJing NieYajing ZhangWeidong HanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yao Wang
Chuan Tong
Hanren Dai
Zhiqiang Wu
Xiao Han
Yelei Guo
Deyun Chen
Jianshu Wei
Dongdong Ti
Zongzhi Liu
Qian Mei
Xiang Li
Liang Dong
Jing Nie
Yajing Zhang
Weidong Han
Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming
description De novo DNA methylation has been associated with T cell exhaustion in cancer immunotherapy. Here the authors show that the pre-treatment of CD19 CAR-T cells with the DNA methyltransferase inhibitor decitabine limits exhaustion and confers enhanced proliferative, effector and memory properties upon antigen exposure, with improved tumor control.
format article
author Yao Wang
Chuan Tong
Hanren Dai
Zhiqiang Wu
Xiao Han
Yelei Guo
Deyun Chen
Jianshu Wei
Dongdong Ti
Zongzhi Liu
Qian Mei
Xiang Li
Liang Dong
Jing Nie
Yajing Zhang
Weidong Han
author_facet Yao Wang
Chuan Tong
Hanren Dai
Zhiqiang Wu
Xiao Han
Yelei Guo
Deyun Chen
Jianshu Wei
Dongdong Ti
Zongzhi Liu
Qian Mei
Xiang Li
Liang Dong
Jing Nie
Yajing Zhang
Weidong Han
author_sort Yao Wang
title Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming
title_short Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming
title_full Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming
title_fullStr Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming
title_full_unstemmed Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming
title_sort low-dose decitabine priming endows car t cells with enhanced and persistent antitumour potential via epigenetic reprogramming
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/933c244786634cf58dfafd51abcccf81
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