Investigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives

Sheshachala Karthik,* Lavanya P Sharma,* Janardhanan C Narayanaswamy OCD Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560029, India*These authors contributed equally to this workCorrespondence: Janardhanan C NarayanaswamyOCD Clinic, Dep...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Karthik S, Sharma LP, Narayanaswamy JC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	glutamate nmda receptor ocd striatum memantine lamotrigine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9340da9525e44fa8a44d4a9d7e835bcd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9340da9525e44fa8a44d4a9d7e835bcd
record_format	dspace
spelling	oai:doaj.org-article:9340da9525e44fa8a44d4a9d7e835bcd2021-12-02T11:22:34ZInvestigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives1178-2021https://doaj.org/article/9340da9525e44fa8a44d4a9d7e835bcd2020-04-01T00:00:00Zhttps://www.dovepress.com/investigating-the-role-of-glutamate-in-obsessive-compulsive-disorder-c-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Sheshachala Karthik,* Lavanya P Sharma,* Janardhanan C Narayanaswamy OCD Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560029, India*These authors contributed equally to this workCorrespondence: Janardhanan C NarayanaswamyOCD Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560029, IndiaTel +91 8026995250Email jcn.nimhans@gmail.comAbstract: Glutamate is a ubiquitous excitatory neurotransmitter, which is involved in normal physiology, a variety of central nervous system (CNS) functions, including excitotoxicity and neuronal migration. It is implicated in the pathogenesis of various neuropsychiatric disorders including epilepsy, Parkinson’s disease, Alzheimer’s dementia, schizophrenia and obsessive compulsive disorder (OCD). Over the years, a growing body of evidence has helped researchers understand the mechanisms underlying glutamatergic involvement in the pathogenesis of these disorders. In this review, we attempt to elucidate the role of glutamate in OCD, which is a chronic psychiatric condition with significant morbidity. This article provides current perspectives on the role played by glutamate in the pathogenesis, clinical symptoms and treatment response in OCD, a critical analysis of existing and emerging evidence, both clinical and preclinical, followed by a summary and future directions.Keywords: glutamate, NMDA receptor, OCD, striatum, memantine, lamotrigineKarthik SSharma LPNarayanaswamy JCDove Medical Pressarticleglutamatenmda receptorocdstriatummemantinelamotrigineNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1003-1013 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	glutamate nmda receptor ocd striatum memantine lamotrigine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	glutamate nmda receptor ocd striatum memantine lamotrigine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Karthik S Sharma LP Narayanaswamy JC Investigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives
description	Sheshachala Karthik,* Lavanya P Sharma,* Janardhanan C Narayanaswamy OCD Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560029, India*These authors contributed equally to this workCorrespondence: Janardhanan C NarayanaswamyOCD Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560029, IndiaTel +91 8026995250Email jcn.nimhans@gmail.comAbstract: Glutamate is a ubiquitous excitatory neurotransmitter, which is involved in normal physiology, a variety of central nervous system (CNS) functions, including excitotoxicity and neuronal migration. It is implicated in the pathogenesis of various neuropsychiatric disorders including epilepsy, Parkinson’s disease, Alzheimer’s dementia, schizophrenia and obsessive compulsive disorder (OCD). Over the years, a growing body of evidence has helped researchers understand the mechanisms underlying glutamatergic involvement in the pathogenesis of these disorders. In this review, we attempt to elucidate the role of glutamate in OCD, which is a chronic psychiatric condition with significant morbidity. This article provides current perspectives on the role played by glutamate in the pathogenesis, clinical symptoms and treatment response in OCD, a critical analysis of existing and emerging evidence, both clinical and preclinical, followed by a summary and future directions.Keywords: glutamate, NMDA receptor, OCD, striatum, memantine, lamotrigine
format	article
author	Karthik S Sharma LP Narayanaswamy JC
author_facet	Karthik S Sharma LP Narayanaswamy JC
author_sort	Karthik S
title	Investigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives
title_short	Investigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives
title_full	Investigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives
title_fullStr	Investigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives
title_full_unstemmed	Investigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives
title_sort	investigating the role of glutamate in obsessive-compulsive disorder: current perspectives
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/9340da9525e44fa8a44d4a9d7e835bcd
work_keys_str_mv	AT karthiks investigatingtheroleofglutamateinobsessivecompulsivedisordercurrentperspectives AT sharmalp investigatingtheroleofglutamateinobsessivecompulsivedisordercurrentperspectives AT narayanaswamyjc investigatingtheroleofglutamateinobsessivecompulsivedisordercurrentperspectives
_version_	1718395951377285120

Investigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives

Ejemplares similares